1098619-84-1

Basic information

• Product Name: trifluoro-methanesulfonic acid 4-tert-butoxycarbonylamino-2,6-dichloro-phenyl ester
• Synonyms: trifluoro-methanesulfonic acid 4-tert-butoxycarbonylamino-2,6-dichloro-phenyl ester
• CAS NO: 1098619-84-1
• Molecular Weight: 410.198
• Mol File: 1098619-84-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: trifluoro-methanesulfonic acid 4-tert-butoxycarbonylamino-2,6-dichloro-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: trifluoro-methanesulfonic acid 4-tert-butoxycarbonylamino-2,6-dichloro-phenyl ester(1098619-84-1)
• EPA Substance Registry System: trifluoro-methanesulfonic acid 4-tert-butoxycarbonylamino-2,6-dichloro-phenyl ester(1098619-84-1)

Safety Data

• Hazardous Substances Data: 1098619-84-1(Hazardous Substances Data)

Upstream product

• 5930-28-9 4-amino-2,6-dichlorophenol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 155891-93-3 (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 232275-49-9 methyl 4-amino-2,6-dichlorobenzoate 
• 1098619-73-8 2,6-dichloro-4-iodo-benzoic acid methyl ester 
• 1258298-01-9 2,6-dichloro-4-iodo-benzoic acid 
• 409127-35-1 4-tert-butoxycarbonylamino-2,6-dichloro-benzoic acid methyl ester 
• 1258298-20-2 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-formylbenzamide 
• 1258298-19-9 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-vinylbenzamide 
• 1258298-18-8 N-(2-bromopyridin-4-yl)-2,6-dichloro-4-vinylbenzamide 
• 1258293-59-2 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-(hydroxymethyl)benzamide 
• 1258298-17-7 N-(2-bromopyridin-4-yl)-2,6-dichloro-4-iodobenzamide 
• 1258295-54-3 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-(methylsulfonamido)benzamide 
• 1258295-53-2 4-acetamido-2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 
• 1258295-55-4 2,6-dichloro-4-(cyclopropanecarboxamido)-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 
• 1258295-50-9 4-amino-2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 
• 1438897-32-5 tert-butyl 4-(4-(2-bromopyridin-4-ylcarbamoyl)-3,5-dichlorophenyl)-1H-pyrazole-1-carboxylate 

Relevant articles and documents

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

Herein we report our lead optimization effort to identify potent, selective, and orally bioavailable TYK2 inhibitors, starting with lead molecule 3. We used structure-based design to discover 2,6-dichloro-4-cyanophenyl and (1R,2R)-2-fluorocyclopropylamide modifications, each of which exhibited improved TYK2 potency and JAK1 and JAK2 selectivity relative to 3. Further optimization eventually led to compound 37 that showed good TYK2 enzyme and interleukin-12 (IL-12) cell potency, as well as acceptable cellular JAK1 and JAK2 selectivity and excellent oral exposure in mice. When tested in a mouse IL-12 PK/PD model, compound 37 showed statistically significant knockdown of cytokine interferon-γ (IFNγ), suggesting that selective inhibition of TYK2 kinase activity might be sufficient to block the IL-12 pathway in vivo.

PYRIDINE COMPOUNDS AND USES THEREOF

The present invention is directed to pyridine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psych

JANUS KINASE INHIBITOR COMPOUNDS AND METHODS

The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, B, D, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and methods of use thereof