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109904-26-9

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  • 5,6,7,7a-tetrahydro-5 - (triphenylmethyl) thieno [3,2-c] pyridinone CAS:109904-26-9 Chinese manufacturers high-quality

    Cas No: 109904-26-9

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109904-26-9 Usage

Chemical Properties

Beige Solid

Uses

5,6,7,7a-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridinone (cas# 109904-26-9) is a compound useful in organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 109904-26-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,9,0 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 109904-26:
(8*1)+(7*0)+(6*9)+(5*9)+(4*0)+(3*4)+(2*2)+(1*6)=129
129 % 10 = 9
So 109904-26-9 is a valid CAS Registry Number.
InChI:InChI=1/C26H23NOS/c28-25-18-20-19-27(17-16-24(20)29-25)26(21-10-4-1-5-11-21,22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,18,24H,16-17,19H2

109904-26-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-trityl-4,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2-one

1.2 Other means of identification

Product number -
Other names THI050

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:109904-26-9 SDS

109904-26-9Relevant articles and documents

Cu(OTf)2 catalyzed three component strategy for the synthesis of thienopyridine containing spirooxindoles and their cytotoxic evaluation

Parthasarathy,Praveen,Kumar, P. Senthil,Balachandran,Perumal

, p. 15818 - 15830 (2015)

Synthesis of novel spirooxindoles via a three component reaction of thienopyridines, isatins and malononitriles under copper catalysis was accomplished. This one-pot, room temperature protocol allowed the synthesis of diversely substituted spirooxindoles in good to excellent yields. Cytotoxicity towards COLO320 cells revealed that compound 5v possessing a 2,6-difluorobenzyl group (IC50 of 49.1 μM) was found to be highly potent among the screened compounds. In addition, molecular docking of compound 5v into caspase-3 receptors exhibited the largest binding energy (-10.5 kcal mol-1) compared to other compounds. The formation of a DNA ladder for compound 5v also supports the experimental results.

PROCESS FOR PREPARING A PHARMACEUTICAL COMPOUND

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Paragraph 0047-0056, (2013/03/26)

The object of the present invention is a one-pot process for preparing the 2-acetoxy-5-(2-fluoro-α-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-tieno[3,2-c]-pyridine (prasugrel) of the formula (I) by reacting the 5,6,7,7a-tetrahydro-4H-tieno[3,2-c]-pyridine-2-on of the formula (II) with 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)-etanone of the formula (III) or with 2-chloro-1-cyclopropyl-2-(2-fluorphenyl)-etanone of the formula (IIIa) and acetylating of the formed compound of the formula (IV), wherein the reaction is carried out in the presence of an organic base with an acetylation agent without isolating the compound of the formula (IV). The coupling and acetylation are carried out in the presence of the same organic base such as triethylamine, N,N-diisopropyl-ethylamine or pyridine. At the end of the process the prasugrel of the formula (I) is purified by recrystallization from an organic solvent or a mixture of solvents.

METHOD FOR PREPARING PHARMACEUTICALLY ACTIVE INGREDIENT AND INTERMEDIATES THEREOF

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Page/Page column 34-35, (2012/05/05)

The present invention is related to a safe and industrially applicable method for the preparation of 2-acetoxy-5-(2-fluoro-α-cyclopropyl- carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine in a quality suitable for use as pharmaceutically active ingredient wherein the concentration of the impurities of the Formula.(XXIV) or (XXIVa) is reduced.

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