Welcome to LookChem.com Sign In|Join Free

Cas Database

110-86-1

110-86-1

Identification

  • Product Name:Pyridine

  • CAS Number: 110-86-1

  • EINECS:203-809-9

  • Molecular Weight:79.1014

  • Molecular Formula: C5H5N

  • HS Code:2933990090

  • Mol File:110-86-1.mol

Synonyms:NCI-C55301;Pyridin;Pyridine ring;Azine;Azabenzene;CP 32;Piridina;py;Pirydyna;Pyridine,crude,light;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):ToxicT,DangerousN,FlammableF,HarmfulXn

  • Hazard Codes: F:Flammable;

  • Signal Word:Danger

  • Hazard Statement:H225 Highly flammable liquid and vapourH302 Harmful if swallowed H312 Harmful in contact with skin H332 Harmful if inhaled

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. In case of skin contact Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . In case of eye contact First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. If swallowed Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . Vapor irritates eyes and nose. Liquid irritates skin and is absorbed through the skin. Overexposure causes nausea, headache, nervous symptoms, increased urinary frequency. (USCG, 1999) Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aromatic hydrocarbons and related compounds/

  • Fire-fighting measures: Suitable extinguishing media Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Solid streams of water may be ineffective. Use water spray to keep fire-exposed containers cool. Behavior in Fire: Vapor is heavier than air and may travel considerable distance to source of ignition and flash back. (USCG, 1999) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Personal protection: self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS, EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR HOOD DUCTWORK. BURN PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIAL. 3. LARGE QUANTITIES CAN BE COLLECTED & ATOMIZED IN SUITABLE COMBUSTION CHAMBER EQUIPPED WITH APPROPRIATE EFFLUENT GAS CLEANING DEVICE. PYRIDINE SHOULD NOT BE ALLOWED TO ENTER CONFINED SPACE, SUCH AS SEWER, BECAUSE OF POSSIBILITY OF EXPLOSION.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Fireproof. Separated from strong oxidants and strong acids. Cool. Dry. Well closed.OUTSIDE OR DETACHED STORAGE IS PREFERABLE. ISOLATE FROM POWERFUL OXIDIZING MATERIALS AND ACIDS.

  • Exposure controls/personal protection:Occupational Exposure limit valuesRecommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 ppm (15 mg/cu m).Biological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase

Relevant articles and documentsAll total 501 Articles be found

ULTRASOUND - PROMOTED COUPLING OF HETEROARYL HALIDES IN THE PRESENCE OF LITHIUM WIRE. NOVEL FORMATION OF ISOMERIC BIPYRIDINES IN A WURTZ - TYPE REACTION

Osborne, Alan G.,Glass, Kathryn J.,Staley, Miriam L.

, p. 3567 - 3568 (1989)

Ultrasonic irradiation of 2-bromopyridine in THF solution in the presence of lithium wire gives 2,2'-bipyridine, 2,4'-bipyridine and 4,4'-bipyridine, a novel formation of isomers in a Wurtz-type reaction.Similar reaction with 3-bromopyridine mainly results in debromination.

Stereochemistry and properties of the M(II)-N(py) coordination bond in the low-spin dipyridinated iron(II) and cobalt(II) phthalocyanines

Janczak, Jan,Kubiak, Ryszard

, p. 64 - 76 (2003)

A comparison between the coordination bond M(II)-N(py) and vibrational properties and stereochemistry of the dipyridinated iron(II) and cobalt(II) phthalocyaninato complexes, FePc(py)2 and CoPc(py)2 (Pc=C32H16N8, py=C5H5N), is carried out using the single crystal X-ray diffraction and the vibrational spectroscopy. Both dipyridinated complexes have been synthesized in crystalline form by heating of the β-FePc or β-CoPc in pyridine at 160°C. The crystals are formed during the slowly cooling process. The crystal of FePc(py)2 and CoPc(py)2 are isostructural. They crystallize in the space group P21/c of the monoclinic system with two molecules per unit cell. The structural results and coordination bond properties are strictly related in these complexes. The Fe2+ and Co2+ cations are coordinated by four N-isoindole atoms of the phthalocyaninato(2-) macrocycle and axially by two nitrogen atoms of pyridine molecules to form a tetragonal bypyramid. The vibrational M-Nisoindole parameters are much more affected than the corresponding structural parameters by the difference in the electronic structure of the Co and Fe. The axial M(II)-N(py) bond length depends strongly on the electron configuration of the central metal. The value of the M(II)-N(py) bond length of 2.039(2) A? in FePc(py)2 and 2.340(2) A? in CoPc(py)2 clearly evidences on the localization of the unpaired electron on the dz2 orbital of the Co in the cobalt complex. The electron paramagnetic resonance (EPR) spectroscopy and magnetic susceptibility measurements have also detected the unpaired electron in the molecule of CoPc(py)2. EPR and magnetic susceptibility measurements performed on a solid sample of FePc(py)2 shown on its diamagnetic character. The importance of the d(π)→π*(Pc) back donation is manifested in the difference between the values of the C-Nisoindole and C-Nazamethine bond lengths of the Pc macrocycle.

Photochemistry of N-(pyrimidin-2-one-4-yl)pyridinium derivatives. The ring contraction of pyrimidinone into imidazolinone

Wenska,Skalski,Paszyc,Gdaniec

, p. 2178 - 2184 (1995)

Photochemical reactions (λ > 300 nm) of N-(1-methylpyrimidin-2-one)- and N-(1,5-dimethyl-pyrimidin-2-one)pyridinium chlorides were studied in deoxygenated aqueous solution at various pH's. Only the former compound was found to be reactive under these conditions to give pyrimidine ring contraction photoproducts 1-methyl-4-imidazolin-2-one and 1-methyl-4-imidazolin-2-one-5-carboxyaldehyde, with pH-dependent chemical yields. The photochemical pyrimidine ring contraction reaction does not occur for other photochemically reactive pyrimidin-2-ones bearing 3-methylimidazolium-1,1,2,4-triazol-1-yl, or imidazol-1-yl as substituents at the C-4 position. The suggested mechanism of the reaction involves the addition of water to the pyrimidinone part of the N-(1-methylpyrimidin-2-one)pyridinium salt in the excited triplet state as the primary photochemical step. Addition of alcohol to the pyridinium ring was found to be the major reaction under irradiation of N-(1-methylpyrimidin-2-one-4-yl)pyridinium chloride in methanol.

Electrochemical reduction of halopyridines catalyzed by Ni0(bipy)2

Budnikova,Kargin

, p. 128 - 131 (2001)

The possibility of electrochemical reduction of halopyridines in the presence of Ni0(bipy)2 (bipy = 2,2′-bipyridine) was shown, and the features of homo- and cross-coupling with participation of PyX (Py = 2-or 3-pyridyl, X = Cl, Br) were studied.

Kinetics, mechanism, and thermochemistry of the gas-phase reaction of atomic chlorine with pyridine

Zhao,Huskey,Olsen,Nicovich,McKee,Wine

, p. 4383 - 4394 (2007)

A laser flash photolysis-resonance fluorescence technique has been employed to study the kinetics of the reaction of atomic chlorine with pyridine (C 5H5N) as a function of temperature (215-435 K) and pressure (25-250 Torr) in nitrogen bath gas. At T ≥ 299 K, measured rate coefficients are pressure independent and a significant H/D kinetic isotope effect is observed, suggesting that hydrogen abstraction is the dominant reaction pathway. The following Arrhenius expression adequately describes all kinetic data at 299-435 K for C5H5N: k1a = (2.08 ± 0.47) × 10-11 exp[-(1410 ± 80)/T] cm 3 molecule-1 s-1 (uncertainties are 2σ, precision only). At 216 K ≤ T ≤ 270 K, measured rate coefficients are pressure dependent and are much faster than computed from the above Arrhenius expression for the H-abstraction pathway, suggesting that the dominant reaction pathway at low temperature is formation of a stable adduct. Over the ranges of temperature, pressure, and pyridine concentration investigated, the adduct undergoes dissociation on the time scale of our experiments (10 -5-10-2 s) and establishes an equilibrium with Cl and pyridine. Equilibrium constants for adduct formation and dissociation are determined from the forward and reverse rate coefficients. Second- and third-law analyses of the equilibrium data lead to the following thermochemical parameters for the addition reaction: ΔrH°298 = -47.2 ± 2.8 kJ mol-1, ΔrH°0 = -46.7 ± 3.2 kJ mol-1, and ΔrS° 298 = -98.7 ± 6.5 J mol-1 K-1. The enthalpy changes derived from our data are in good agreement with ab initio calculations reported in the literature (which suggest that the adduct structure is planar and involves formation of an N-Cl σ-bond). In conjunction with the well-known heats of formation of atomic chlorine and pyridine, the above ΔrH values lead to the following heats of formation for C 5H5N-Cl at 298 K and 0 K: ΔfH° 298 = 216.0 ± 4.1 kJ mol-1, Δ fH°0 = 233.4 ± 4.6 kJ mol-1. Addition of Cl to pyridine could be an important atmospheric loss process for pyridine if the C5H5N-Cl product is chemically degraded by processes that do not regenerate pyridine with high yield. the Owner Societies.

Synthesis of branched ultrahigh-molecular-weight polyethylene using highly active neutral, single-component Ni(II) catalysts

Chen, Zhou,Mesgar, Milad,White, Peter S.,Daugulis, Olafs,Brookhart, Maurice

, p. 631 - 636 (2015)

Neutral nickel methyl complexes incorporating 2,8-diarylnaphthyl groups have been synthesized and characterized. Salicylaldiminato nickel systems 1a,b are exceptionally active neutral nickel single component catalysts for the polymerization of ethylene capable of producing lightly branched ultrahigh-molecular-weight polyethylene (UHMWPE). In addition, complex 1a shows a "quasi-living" polymerization behavior. (Chemical Equation Presented).

Pyridyl-and pyridylperoxy radicals-a matrix isolation study

Korte, Andre,Mardyukov, Artur,Sander, Wolfram

, p. 1324 - 1329 (2014)

The three isomeric pyridyl radicals 2a-c were synthesised using flash vacuum pyrolysis in combination with matrix isolation and characterised by infrared spectroscopy. The IR spectra are in good agreement with spectra calculated using density functional theory methods. The reaction of the pyridyl radicals 2 with molecular oxygen leads to the formation of the corresponding pyridylperoxy radicals 3a-c. The peroxy radicals 3 are photolabile, and irradiation results in syn-anti isomerisation of 3a and 3b and ring expansion of all three isomers of 3.

Blues et al.

, p. 466 (1974)

Selective and Efficient Photoinactivation of Intracellular Staphylococcus aureus and MRSA with Little Accumulation of Drug Resistance: Application of a Ru(II) Complex with Photolabile Ligands

Sun, Weize,Jian, Yao,Zhou, Mengxue,Yao, Yishan,Tian, Na,Li, Chao,Chen, Jun,Wang, Xuesong,Zhou, Qianxiong

, p. 7359 - 7370 (2021)

Novel antibacterial agents capable of efficiently sterilizing intracellular Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) but with low cytotoxicity and low resistance development are quite appealing. In this work, three Ru(II) complexes with photolabile ligands were explored to realize such a goal. Complex 3 (5 μM) can inhibit more than 90% growth of S. aureus/MRSA that has invaded in J774A.1 cells upon visible light irradiation, being much more efficient than vancomycin. In similar conditions, negligible dark- and phototoxicity were found toward the host cells. The bactericidal activity is highly correlated with DNA covalent binding by the Ru(II) fractions generated after ligand photodissociation. Moreover, S. aureus quickly developed resistance toward vancomycin, while negligible resistance toward complex 3 even after 700 generations was obtained. These appealing results may pave a new way for fighting against intracellular antibiotic-resistant pathogens.

Increase in the coordination number of a cobalt porphyrin after photo-induced interfacial electron transfer into nanocrystalline TiO2

Achey, Darren,Ardo, Shane,Meyer, Gerald J.

, p. 9865 - 9872 (2012)

Spectroscopic, electrochemical, and kinetic data provide compelling evidence for a coordination number increase initiated by interfacial electron transfer. Light excitation of CoI(meso-5,10,15,20-tetrakis(4- carboxyphenyl)porphyrin) anchored to a nanocrystalline TiO2 thin film, abbreviated CoIP/TiO2, immersed in an acetonitrile:pyridine electrolyte resulted in rapid excited state injection, kinj > 108 s-1, to yield Co IIP/TiO2(e-), followed by axial coordination of pyridine to the CoIIP and hence an increase in coordination number from four to five. The formal oxidation state and coordination environment of the Co metalloporphyrin on TiO2 were assigned through comparative studies in fluid solution as well as by comparisons to previously reported data. The kinetics for pyridine coordination were successfully modeled with a pseudo-first order kinetic model that yielded a second-order rate constant of k+py = 2 × 108 M-1 s-1. Spectro-electrochemical measurements showed that pyridine coordination resulted in a ~200 mV negative shift in the CoII/I reduction potential, E°(CoII/I/TiO2) = -0.72 V and E°(Co II/I(py)/TiO2) = -0.85 V vs NHE. With some assumptions, this indicated an equilibrium formation constant Kf = 400 M -1 for the CoIIP(py)/TiO2 compound. The kinetics for charge recombination were non-exponential under all conditions studied, but were successfully modeled by the Kohlrausch-Williams-Watts (KWW) function with observed rate constants that decreased by about a factor of 100 when pyridine was present. The possible mechanisms for charge recombination are discussed.

Bis(μ-acetato)(μ-oxo)bis(tris(pyridine)ruthenium(III)) Ion: A Ruthenium Analogue of the Hemerythrin Active Center

Sasaki, Yoichi,Suzuki, Masakazu,Tokiwa, Ayako,Ebihara, Masahiro,Yamaguchi, Tadashi,et al.

, p. 6251 - 6252 (1988)

Ruthenium(III) is known to form the Ru2(μ-OH)2(μ-CH3COO) core rather an Ru2(μ-O)(μ-CH3COO)2 species with the facial-blocking ligand tacn.We wish to report here a new dimeric complex, III2(μ-O)(μ-CH3COO)2(py)6>2+ (py=pyridine).

REDUCTIVE DECYANATION OF PYRIDINECARBONITRILES BY TITANIUM TRICHLORIDE

Clerici, A.,Porta, O.

, p. 1675 - 1676 (1980)

Titanium(III) chloride promotes reductive decyanation of 4-CN- and 2-CN-pyridine.The role of complex forming agents is discussed.

Crystalline CrV0.95P0.05O4 catalyst for vapor-phase oxidation of picolines

Song, Zhaoxia,Matsushita, Toshiyuki,Shishido, Tetsuya,Takehira, Katsuomi

, p. 1306 - 1307 (2002)

CrV0.95P0.05O4 prepared as a pure crystalline form was found to be highly active for the vapor-phase oxidation of picolines to the corresponding aldehydes and acids in the presence of water.

-

Brown,Rao

, p. 3164 (1955)

-

Photoinduced electron transfer reactions: Nitrogen-oxygen bond cleavage in reduced N-(aryloxy)pyridinium and N,N′-dialkoxy-4,4′-bipyridinium salts

W?lfle, Ingrid,Lodaya, Jayant,Sauerwein, Bj?rn,Schuster, Gary B.

, p. 9304 - 9309 (1992)

N-(Aryloxy)pyridinium cations and N,N-dialkoxy-4,4′-bipyridinium dications form charge-transfer complexes with neutral hydrocarbons. Irradiation of these charge-transfer complexes leads to the cleavage of the nitrogen-oxygen bond and the formation of an aryloxy radical in the first case, but no reaction is observed for the second. In contrast, electron transfer to the dialkoxybipyridinium cation from the triplet state of 9-acetylanthracene leads to nitrogen-oxygen bond cleavage and the formation of an alkoxy radical. The rate constants for nitrogen-oxygen bond cleavage (kBC) in the reduced pyridinium salts were estimated by time-resolved laser spectroscopy. For N-(4-cyanophenoxy)pyridinium tetrafluoroborate, kBC> 1011 s-1, and for N,N-diethoxy-4,4′-bipyridinium (bis)hexafluorophosphate), kBC = 1.4 × 104 s-1. The effects of structure on the dynamics of the excited charge-transfer complexes and on kBC are discussed.

Synthesis and properties of a new (octaethylporphyrinato)-manganese(III)–pyridinyl-substituted pyrrolidinofullerene dyad

Ovchenkova,Bichan,Lomova

, p. 1503 - 1508 (2016)

The formation of a porphyrin–fullerene dyad from 2′-(pyridin-4-yl)-5′-(pyridin-2-yl)-1′-(pyridin-3-ylmethyl)-2′,5′-dihydro-1′H-pyrrolo[3′,4′: 1,9](C60-Ih)[5,6]fullerene and (2,3,7,8,12,13,17,18-octaethylporphyrinato) manganese(III) with axial chloride ligand has been studied on a quantitative level with the goal of obtaining supramolecules possessing biological activity. Preliminarily, the reaction of manganese(III) porphyrin with pyridine has been studied. The donor–acceptor dyads are formed either instantaneously and reversibly (pyridine) or slowly and irreversibly (substituted fullerene). In both cases, the reaction is a one-step process for which thermodynamic and kinetic parameters have been determined. The results can be used to optimize conditions for the synthesis of porphyrin–fullerene dyads. The obtained dyads have been characterized by spectral data and stability constants.

In situ DRIFTS study of picoline oxidation over CrV0.95P0.05O4 catalyst

Shishido,Song,Matsushita,Takaki,Takehira

, p. 2710 - 2718 (2003)

The catalytic behaviour of CrV0.95P0.05O4 has been investigated in the selective oxidations of 2-, 3- and 4-picolines by in situ DRIFTS, and the model of picoline adsorption and the oxidation mechanism are proposed. Both Lewis and Bronsted acid sites were detected on the surface of CrV0.95P0.05O4, and the number of the latter increased on the addition of steam in the reaction mixture, resulting in enhanced activity for selective oxidations. The enhanced activity due to water addition is interpreted by the fact that Bronsted acid sites are produced by the hydrolysis of V-O-Cr and activate picoline molecules by withdrawing the electrons of the pyridine ring, and at the same time, enable to accelerate the desorption of the acid products from the catalyst surface. Every 2-, 3- and 4-picoline was adsorbed on the catalyst surface via the N atom donating the electrons to the Bronsted acid sites, and the substituted methyl group was oxidized via hydrogen abstraction by surface oxide ion to form the radical intermediate, followed by oxygen insertion to produce the corresponding aldehyde and then acid. Even in the absence of gaseous oxygen, the oxygenated products were formed and observed over the catalyst surface by in situ DRIFTS. Thus, a Mars and van Krevelen mechanism was suggested for 2-, 3- and 4-picolines oxidations based on the spectral analysis. Both 2- and 4-picolines were more quickly oxidized than 3-picoline due to the inductive hyper-conjugative effect of nitrogen, resulting in an easy leaving of proton from the methyl group. 4-Picoline produced almost quantitatively isonocotinic acid, while 2-picoline afforded 2-picoline aldehyde as the main product due to the unstability of the acid product, i.e., the decarboxylation of picolinic acid took place to form pyridine.

Acid-Base Kinetics of Pyridine Studied with a Slow Spectrophotometric Indicator in Methanol

Marshall, David B.,Eyring, Edward M.,Strohbusch, Frank,White, Robert D.

, p. 7065 - 7067 (1980)

The protonation-deprotonation kinetics of pyridine in methanol has been studied by the electric field jump technique.Kinetic measurements of the electric field insensitive equilibrium B + H+ (k1) BH+ (k-1), where B denotes pyridine, were obtained by coupling the equilibrium with a field-sensitive, visibly colored indicator equilibrium.Use of the "slow" indicator 2,2',4,4',6,6'-hexanitrodiphenylamine allowed observation of the slower of the two relaxation times of the coupled system in a time range where measurements could be made with sufficient precision for a reliable extraction of the rate constants k1 and k-1 from the data.The values obtained are k1 = 1.57 +/- 0.32 * 1010 dm3mol-1s-1 and k-1 = 8.43 +/- 1.69 * 104 s-1.The value for k1 is within the expected limits for a diffusion-controlled reaction in this solvent.An ionic reaction radius of 3.9 Angstroem is calculated from the protonation rate constant value, which indicates that the neutral species involved is probably a hydrogen-bonded pyridine-methanol complex rather than free pyridine.The value for k-1 is 1 order of magnitude greater than the constant for methyl-substituted pyridines, reflecting unsubstituted pyridine's lower basicity in methanol.

-

Schreiber,Shriner

, p. 1896 (1935)

-

Activation and deactivation of a chemical transformation by an electromagnetic field: Evidence for specific microwave effects in the formation of grignard reagents

Gutmann, Bernhard,Schwan, Alexander M.,Reichart, Benedikt,Gspan, Christian,Hofer, Ferdinand,Kappe, C. Oliver

, p. 7636 - 7640 (2011)

It's field density, not temperature! Modifying the electric field strength in a microwave experiment can completely change the outcome of a reaction. Whereas a low field strength in Grignard reagent formation from Mg metal and aryl halide leads to acceleration of the initiation step, using a high field strength at the same temperature suppresses Mg insertion, favoring solvent decomposition and passivation of the Mg metal (see scheme). Copyright

Organotin mediated nitration in heteroaromatic series using tetranitromethane or dinitrogen tetroxide

Favresse, Fabien,Fargeas, Valérie,Charrue, Pierre,Lebret, Bruno,Piteau, Marc,Quintard, Jean-Paul

, p. 187 - 190 (2000)

2-Trimethylstannylated benzo[b]furan, benzo[b]thiophene, N-substituted indoles and pyridine afford the corresponding nitro derivatives in regioselective fashion upon treatment with tetranitromethane (using sun-lamp irradiation in the case of N-containing

Examining the Effects of Monomer and Catalyst Structure on the Mechanism of Ruthenium-Catalyzed Ring-Opening Metathesis Polymerization

Wolf, William J.,Lin, Tzu-Pin,Grubbs, Robert H.

, p. 17796 - 17808 (2019)

The mechanism of Ru-catalyzed ring-opening metathesis polymerization (ROMP) is studied in detail using a pair of third generation ruthenium catalysts with varying sterics of the N-heterocyclic carbene (NHC) ligand. Experimental evidence for polymer chelation to the Ru center is presented in support of a monomer-dependent mechanism for polymerization of norbornene monomers using these fast-initiating catalysts. A series of kinetic experiments, including rate measurements for ROMP, rate measurements for initiation, monomer-dependent kinetic isotope effects, and activation parameters were useful for distinguishing chelating and nonchelating monomers and determining the effect of chelation on the polymerization mechanism. The formation of a chelated metallacycle is enforced by both the steric bulk of the NHC and by the geometry of the monomer, leading to a ground-state stabilization that slows the rate of polymerization and also alters the reactivity of the propagating Ru center toward different monomers in copolymerizations. The results presented here add to the body of mechanistic work for olefin metathesis and may inform the continued design of catalysts for ROMP to access new polymer architectures and materials.

Mechanistic Studies in the Deoxygenation of Pyridine N-Oxide: A New 1,2 Elimination

Hwu, Jih Ru,Wetzel, John M.

, p. 400 - 402 (1985)

-

2,2'-Diphenyl-Δ3,3'-bi-3H-indole-1,1'-dioxide: Competitive Demethylation and Redox Reactions

Bruni, Paolo,Conti, Carla,Tosi, Giorgio

, p. 1311 - 1316 (1988)

Competitve demethylation and redox reactions induced by 2,2'-diphenyl-Δ3,3'-bi-3H-indole-1,1'-dioxide, 1 (dinitrone) on several nitrogen bearing compounds (pyridines, amides, indoles, hydrazones and amines) are reported. - Keywords: 2,2'-Diphenyl-Δ3,3'-bi-3H-indole-1,1'-dioxide; Demethylation; Oxidation

Mathews, J. H.,Krause, E. L.,Bohnson, L. van

, p. 398 - 413 (1917)

-

Paterson,Spring

, p. 325 (1954)

-

Reductive Dimerization of Pyridine N-Oxide

Kurbatova, A. S.,Kurbatov, Yu. V.

, p. 113 (1988)

-

Mechanism of the reaction of atomic carbon with pyrrole. Evidence for the intermediacy of a novel dehydropyridinium ylide

Emanuel, Calvin J.,Shevlin, Philip B.

, p. 5991 - 5992 (1994)

-

-

Kline,Turkevich

, p. 1710,1714 (1944)

-

Kahlenberg,Brewer

, p. 283 (1908)

Stepwise Mechanism of the Rhenium(V) Porphyrin Reaction with Pyridine, and the Chemical Structure of the Donor–Acceptor Complex

Bichan,Ovchenkova,Lomova

, p. 703 - 709 (2019)

Abstract: Chemical thermodynamics and UV, visible, IR, 1H NMR, and mass spectrometry are used to study the complex reaction of (5,15-bis(4'-methoxyphenyl)-3,7,13,17-tetramethyl-2,8,12,18-tetraethylporphinato) (oxo)(chloro)rhenium(V) (O=Re(Cl)P) with pyridine (Py) and the chemical structure of the product. The nature and stoichiometry of the reaction are established and the quantitative parameters of two-way stepwise reactions are determined during a complex reaction. There is reversible replacement of Cl– ions by pyridine molecules with constant K1 of (4.7 ± 1.1) × 102 L/mol and the formation of cationic complex compound [O=Re(Py)P]+Cl– in the first stage. The second stage is the reversible addition of two pyridine molecules ([O=Re(Py)3P]+Cl–) with constant K2 = (0.10 ± 0.03) L2/mol2. The reaction studied is a model for processes in self-assembling systems based on metalloporphyrins and pyridyl derivatives of carbon nanoforms for the formation of active layers with photoinduced charge separation in hybrid solar cells.

Structures, Lewis Acidities, Electrophilicities, and Protecting Group Abilities of Phenylfluorenylium and Tritylium Ions

Follet, Elsa,Mayer, Peter,Berionni, Guillaume

, p. 623 - 630 (2017)

The isolation, characterization, and the first X-ray structures of a fluorenylium ion and its Lewis adducts with nitrogen- and phosphorus-centered Lewis bases are reported. Kinetics of the reactions of a series of fluorenylium ions with reference π-, σ-, and n-nucleophiles of various sizes and nucleophilicities allowed the interplay between electronic and structural parameters on the electrophilicities of these planarized tertiary carbenium ions to be elucidated. Structure–reactivity correlations and extensive comparisons of their reactivities with those of di- and triarylcarbenium ions are described. Quantitative determination of the electrofugalities of fluorenylium ions revealed to which extent they are complementing tritylium ions as protecting groups and how their tuning is possible. Determination of the equilibrium constants of the Lewis adducts formation between pyridines of calibrated Lewis basicities and phenylfluorenylium and tritylium ions allowed the determination of their Lewis acidities and to showcase the potential of these carbon-centered Lewis acids in catalysis.

Energetics and structure of nicotinic acid (Niacin)

Gon?alves, Elsa M.,Bernardes, Carlos E. S.,Diogo, Hermínio P.,Minas Da Piedade, Manuel E.

, p. 5475 - 5485 (2010)

The standard molar enthalpies of formation and sublimation of crystalline (monoclinic, space group P21/c) nicotinic acid (NA), at 298.15 K, were determined as δfHm°(NA, cr) = -344.7 ± 1.2 kJ·mol-1 and δsubHm°(NA) = 112.1 ± 0.5 kJ·mol-1 by using combustion calorimetry, drop-sublimation Calvet microcalorimetry, and the Knudsen effusion method. The experimental determinations were all based on a sample of NIST Standard Reference Material 2151, which was characterized in terms of chemical purity, phase purity, and morphology. From the above results, δfHm° (NA, g) = -232.6 ± 1.3 kJ·mol-1 could be derived. On the basis of this value and on published experimental data, the enthalpy of the isodesmic reaction nicotinic acid(g) + benzene(g) ? benzoic acid(g) + pyridine(g) was calculated as -3.6 ± 2.7 kJ·mol-1 and compared with the corresponding predictions by the B3LYP/cc-pVTZ (-3.6 kJ·mol-1), B3LYP/aug-cc-pVTZ (-3.7 kJ·mol -1), B3LYP/6-311++G(d,p) (-4.2 kJ·mol-1), G3MP2 (-4.3 kJ·mol-1), and CBS-QB3 (-4.0 kJ·mol-1) quantum chemistry models. The excellent agreement between the experimental and theoretical results supports the reliability of the δfHm° (NA, cr), δsubHm°(NA), and δfHm°(NA, g) recommended in this work. These data can therefore be used as benchmarks for discussing the energetics of nicotinic acid in the gaseous and crystalline states and, in particular, to evaluate differences imparted to solid forms by the production and processing methods. Such differences are perhaps at the root of the significant inconsistencies found between the published enthalpies of sublimation of this important active pharmaceutical ingredient and thermochemical standard. The molecular packing in the crystalline phase studied in this work was also discussed and its influence on the molecular structure of nicotinic acid was analyzed by comparing bond distances and angles published for the solid state with those predicted by the B3LYP/cc-pVTZ method. No advantage in terms of accuracy of the structural predictions was found by the use of the larger aug-cc-pVTZ or 6-311++G(d,p) basis sets.

New silver(I) pyridinecarboxylate complexes: Synthesis, characterization, and antimicrobial therapeutic potential

Vargova,Almasi,Hudecova,Titkova,Rostasova,Zelenak,Gyoeryova

, p. 1002 - 1021 (2014)

Silver(I) pyridinecarboxylates (AgPIC (1), AgNIC (2), [Ag(HDIPIC)]0. 75H2O (3), PIC = picolinate, NIC = nicotinate, HDIPIC = dipicolinate) were prepared by solvothermal syntheses and their characterization were completed by elemental, spectral, and thermal analyses. To assign the pyridinecarboxylate coordination mode in the complexes, detailed mid-infrared spectral data and Δ(as-s) comparisons were accomplished. In addition, silver(I) pyridinecarboxylate antimicrobial activities and stability by 1H NMR spectra were determined. Moreover, the spectral, thermal, and antimicrobial properties of silver(I) and previously prepared zinc(II) pyridinecarboxylates were compared and discussed. 2014

Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from saccharomyces cerevisiae

Smith, Brian C.,Anderson, Mark A.,Hoadley, Kelly A.,Keck, James L.,Cleland, W. Wallace,Denu, John M.

, p. 243 - 256 (2012)

Nicotinamidases catalyze the hydrolysis of nicotinamide to nicotinic acid and ammonia. Nicotinamidases are absent in mammals but function in NAD + salvage in many bacteria, yeast, plants, protozoa, and metazoans. We have performed structural and kinetic investigations of the nicotinamidase from Saccharomyces cerevisiae (Pnc1). Steadystate product inhibitor analysis revealed an irreversible reaction in which ammonia is the first product released, followed by nicotinic acid. A series of nicotinamide analogues acting as inhibitors or substrates were examined, revealing that the nicotinamide carbonyl oxygen and ring nitrogen are critical for binding and reactivity. X-ray structural analysis revealed a covalent adduct between nicotinaldehyde and Cys167 of Pnc1 and coordination of the nicotinamide ring nitrogen to the active-site zinc ion. Using this structure as a guide, the function of several residues was probed via mutagenesis and primary 15N and 13C kinetic isotope effects (KIEs) on V/K for amide bond hydrolysis. The KIE values of almost all variants were increased, indicating that C-N bond cleavage is at least partially rate limiting; however, a decreased KIE for D51N was indicative of a stronger commitment to catalysis. In addition, KIE values using slower alternate substrates indicated that C-N bond cleavage is at least partially rate limiting with nicotinamide to highly rate limiting with thionicotinamide. A detailed mechanism involving nucleophilic attack of Cys167, followed by elimination of ammonia and then hydrolysis to liberate nicotinic acid, is discussed. These results will aid in the design of mechanism-based inhibitors to target pathogens that rely on nicotinamidase activity.

-

Blau

, (1889)

-

-

Ahrens

, p. 3039 (1893)

-

Nickel-catalyzed reductive defunctionalization of esters and amides to aromatic hydrocarbons

Mondal, Manoj,Bharali, Pankaj

, p. 13211 - 13214 (2017)

The removal of ester and amide groups is of fundamental significance in organic syntheses. Under non-catalytic conditions, hydride sources are chiefly used for their reduction. Recently developed Ni-catalyzed one-pot reductive activation of esters and ami

5,6-DIHYDROPYRIDINE : SYNTHESIS AND CHARACTERIZATION

Lasne, Marie-Claire,Ripoll, Jean-Louis,Guillemin, Jean-Claude,Denis, Jean-Marc

, p. 3847 - 3848 (1984)

5,6-dihydropyridine 1 is synthesized either by flash vacuum thermolysis of 1-azabicyclo oct-2-ene 3 or by dehydrochlorination over solid bases of N-chloro-1,2,5,6-tetrahydropyridine 4 and characterized at low temperature by its (1)H and (13)C nmr and ir spectra.

-

Sohl,Shriner

, p. 4168 (1931)

-

A kinetic oxymoron: Concentration-dependent first-order rate constants for hydrolysis of ceftazidime

Fubara, Josephine O.,Notari, Robert E.

, p. 53 - 58 (1998)

The influence of pH, temperature, and buffers on the hydrolysis of 10- 4 M ceftazidine was previously reported. The pH-rate profiles showed that maximum stability occurred in the pH-independent region from 4.5 to 6.5. In the present study, hydrolysis rates of 0.031, 0.14, 0.25, and 0.35 M ceftazidime were measured at 30 and 65°C, pH 5.5-6.2. The data were consistent with β-lactam hydrolysis and the rapid release of pyridine. The sum of the time-dependent concentrations of ceftazidime and pyridine provided mass balance. Simultaneous nonlinear regression for ceftazidime loss and pyridine formation provided similar rate constants (k) to those determined from first-order plots of ceftazidime loss. Although the loss of ceftazidime was first-order for each initial concentration, the k values increased as the initial concentrations increased. Plots of k versus initial concentration were linear with intercepts similar to the k values for 10-4 M solutions, thus implying that ceftazidime catalyzed its own degradation. At the pH of these studies ceftazidime exists as a base. The ceftazidime catalytic constant, calculated from the slope of the plot, was similar to that found for the general-base catalyst, HPO42-. Therefore, it is feasible that ceftazidime also behaved as a intermolecular general-base catalyst. However, first-order plots exhibited excellent linearity even though the catalyst (ceftazidime) was consumed. This would require that the catalytic moieties on ceftazidime remained relatively constant throughout its hydrolysis. This hypothesis was shown to be consistent with literature reports which indicate that the general-base catalytic groups can remain relatively constant during cephalosporin hydrolysis.

-

Ciamician,Silber

, p. 187 (1885)

-

Hydrolysis kinetics of 2-cyanopyridine, 3-cyanopyridine, and 4-cyanopyridine in high-temperature water

Fu, Jie,Ren, Haoming,Shi, Chaojun,Lu, Xiuyang

, p. 641 - 648 (2012)

We report herein the kinetic studies on hydrolysis of three cyanopyridines in high-temperature water. 3-Cyanopyridine, 4-cyanopyridine and 2-cyanopyridine underwent consecutive hydrolysis to the corresponding pyridinecarboxamides and picolinic acids. Further decarboxylation to pyridine was observed for 2-cyanopyridine hydrolysis. Experiments at different initial reactant concentrations revealed that these compounds exhibited the first-order kinetics. Experiments at different temperatures showed that the first-order rate constants displayed an Arrhenius behavior with activation energies of 74.3, 40.3, and 83.7 kJ mol-1 for 3-cyanopyridine, 4-cyanopyridine, 2-cyanopyridine, respectively. The activation energies obtained for 3-pyridinecarboxamide, 4-pyridinecarboxamide and 2-pyridinecarboxamide hydrolysis are 80.1, 32.7, and 70.5 kJ mol-1, respectively. The effect of substituent position on activation energies for cyanopyridine and pyridinecarboxamide hydrolysis is ortho a meta > para.

Protolytic Kinetics of Some Pyridine Derivatives in Non-buffered Aqueous Solution

Ando, Isao,Ujimoto, Kikujiro,Kurihara, Hirondo

, p. 713 - 716 (1982)

The deprotonation rates of the conjugate acids of 2,2'-bipyridine and pyridine, and the protonation rates of 2-aminopyridine and 4-aminopyridine were measured in non-buffered aqueous solution by means of a stopped-flow pH jump method.These pyridine derivatives showed quite slow protolytic behavior, similar to that of 1,10-phenanthroline and cyclopentadienes: the deprotonation rate constants of conjugate acids of 2,2'-bipyridine and pyridine are (4.8 +/- 0.7)*10-1 and (6.0 +/- 2.2)*10-2 s-1, respectively.The deprotonation rates of barbituric acid and acetylcyclopentadiene as authentic samples were also measured.Their deprotonation rate constants are in good agreement with the literature values, this demonstrates the validity and the applicability of the stopped-flow pH jump method.This method is superior to the NMR method for the determination of the protontransfer rates of azaaromatic compounds.

-

Haitinger,Lieben

, p. 339 (1883)

-

Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate

Hou, Xiaoya,Zhou, Sen,Li, Yuli,Guo, Minjie,Zhao, Wentao,Tang, Xiangyang,Wang, Guangwei

, p. 9313 - 9318 (2020)

Here we present a novel annulation of pyridinium salts with BrCF2CO2Et to access the indolizine derivatives with high efficiency. The α substitution of pyridine plays a key role in determining the reaction pathways. Various types of indolizines can be conveniently accessed from easily available pyridinium salts under mild and simple reaction conditions.

Alkylpyridiniums. 1. Formation in model systems via thermal degradation of trigonelline.

Stadler, Richard H,Varga, Natalia,Hau, Joerg,Vera, Francia Arce,Welti, Dieter H

, p. 1192 - 1199 (2002)

Trigonelline is a well-known precursor of flavor/aroma compounds in coffee and undergoes significant degradation during roasting. This study investigates the major nonvolatile products that are procured after trigonelline has been subjected to mild pyrolysis conditions (220-250 degrees C) under atmospheric pressure. Various salt forms of trigonelline were also prepared and the thermally produced nonvolatiles analyzed by thin layer chromatography, liquid chromatography-electrospray ionization tandem mass spectrometry, and (1)H and (13)C nuclear magnetic resonance. Results revealed the decarboxylated derivative 1-methylpyridinium as a major product of certain salts, the formation of which is positively correlated to temperature from 220 to 245 degrees C. Moreover, trigonelline hydrochloride afforded far greater amounts of 1-methylpyridinium compared to the monohydrate over the temperature range studied. Investigations into other potential quaternary amine products of trigonelline also indicate nucleophilic substitution reactions that lead to dialkylpyridiniums, albeit at concentration levels approximately 100-fold lower than those recorded for 1-methylpyridinium.

Degradation of cephaloridine on alkaline hydrolysis

Vilanova,Munoz,Donoso,Garcia-Blanco

, p. 1619 - 1625 (1993)

-

Miller,V.R.,Ryschkewitsch,G.E.

, p. 1558 - 1562 (1970)

Complexes of 2,2',2 -Nitrilotriphenol. Part 3. Crystal and Molecular Structures of Three Aluminium Complexes

Mueller, Edgar,Buergi, Hans-Beat

, p. 520 - 533 (1987)

Crystal and molecular structures of three Al(III) complexes of the tripod ligand 2,2',2 -nitrilotriphenolate (I) are presented.They all show 5-coordinate Al in approximately trigonal bipyramidal geometry, with an external nucleophile X occupying the second axial position.X is OH- in -+ (quin = quinuclidine), N in (py = pyridine), and one of the O-atoms of a second molecule in the dimeric 2>.Correlated variations in the axial bond lengths of the trigonal bipyramid are observed: 2> Al-Nint. = 2.094 Angstroem, Al-Oext. = 1.850 Angstroem; : Al-Nint. = 2.153 Angstroem, Al-Next. = 1.992 Angstroem; -: Al-Nint. = 2.278 Angstroem, Al-Oext. = 1.765 Angstroem.They are interpreted in terms of a dissociative reaction path at the Al(III) centre.

Deaminative chlorination of aminoheterocycles

Ghiazza, Clément,Faber, Teresa,Gómez-Palomino, Alejandro,Cornella, Josep

, p. 78 - 84 (2021/12/23)

Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]

Coordination Chemistry of Borane in Solution: Application to a STING Agonist

Lemaire, Sébastien,Zhdanko, Alexander,van der Worp, Boris A.

supporting information, (2022/04/09)

Equilibrium constants were determined for ligand exchange reactions of borane complexes with various oxygen, sulfur, nitrogen, and phosphorus nucleophiles in solution, and a binding affinity scale was built spanning a range of 12 orders of magnitude. While the Keq are minimally dependent on the solvent, the rate of ligand exchange varies significantly. The fastest and slowest rates were observed in THF and CDCl3, respectively. Moreover, the ligand exchange rate differs in a very broad range depending on stability of the starting complex. Binding of BH3 was found to be much more sensitive to steric factors than protonation. Comparing nitrogen bases having equal steric properties, a linear correlation of BH3 binding affinity vs. Br?nsted acidity was found. This correlation can be used to quickly estimate the BH3 binding affinity of a substrate if pKa is known. Kinetic studies suggest the ligand exchange to occur as a bimolecular SN2 reaction unless other nucleophilic species were present in the reaction mixture.

CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA

-

, (2022/01/12)

The present invention provides a novel bridged artificial nucleic acid and an oligomer containing the same as a monomer. The present invention provides specifically a compound represented by general formula (I) (wherein each symbol is the same as defined in the specification) or salts thereof; as well as an oligonucleotide compound represented by general formula (I′) (wherein each symbol is the same as defined in the specification) or salts thereof.

Pd/C-catalyzed one-pot Suzuki-Miyaura cross-coupling/hydrogenation of pyridine derivatives

Pitna, Dinda B.,Tanaka, Nao,Usuki, Toyonobu

, (2021/07/31)

Using bromopyridines and methoxyphenyl boronic acid as starting materials, consecutive Suzuki-Miyaura cross-coupling and hydrogenation reactions were undertaken using a heterogeneous Pd/C catalyst in one-pot manner under mild conditions (balloon-pressure at room temperature for hydrogenation) with excellent yield. To counter Pd leaching as well as catalyst poisoning, addition of an appropriate amount of H2O was crucial to achieving successful AcOH-promoted hydrogenation, which ensured a selective reduction of the pyridine rings to the corresponding piperidines.

Clean protocol for deoxygenation of epoxides to alkenes: Via catalytic hydrogenation using gold

Fiorio, Jhonatan L.,Rossi, Liane M.

, p. 312 - 318 (2021/01/29)

The epoxidation of olefin as a strategy to protect carbon-carbon double bonds is a well-known procedure in organic synthesis, however the reverse reaction, deprotection/deoxygenation of epoxides is much less developed, despite its potential utility for the synthesis of substituted olefins. Here, we disclose a clean protocol for the selective deprotection of epoxides, by combining commercially available organophosphorus ligands and gold nanoparticles (Au NP). Besides being successfully applied in the deoxygenation of epoxides, the discovered catalytic system also enables the selective reduction N-oxides and sulfoxides using molecular hydrogen as reductant. The Au NP catalyst combined with triethylphosphite P(OEt)3 is remarkably more reactive than solely Au NPs. The method is not only a complementary Au-catalyzed reductive reaction under mild conditions, but also an effective procedure for selective reductions of a wide range of valuable molecules that would be either synthetically inconvenient or even difficult to access by alternative synthetic protocols or by using classical transition metal catalysts. This journal is

Process route upstream and downstream products

Process route

3-ethylpyridine
536-78-7,151103-56-9

3-ethylpyridine

2-Ethylpyridine
100-71-0

2-Ethylpyridine

4-Ethylpyridine
536-75-4,151103-55-8

4-Ethylpyridine

pyridine
110-86-1

pyridine

ethylbenzene
100-41-4,27536-89-6

ethylbenzene

Conditions
Conditions Yield
With Fuller's Earth; benzene; at 540 - 650 ℃; under 7355.08 Torr;
5-(2,4-dinitro-anilino)-penta-2,4-dienal
53405-99-5

5-(2,4-dinitro-anilino)-penta-2,4-dienal

ethanol
64-17-5

ethanol

pyridine
110-86-1

pyridine

2,4-dinitro-1-ethoxybenzene
610-54-8

2,4-dinitro-1-ethoxybenzene

Conditions
Conditions Yield
piperidine
110-89-4

piperidine

sulfure de pentamethylene
1613-51-0

sulfure de pentamethylene

2-methylthiolane
1795-09-1

2-methylthiolane

pyridine
110-86-1

pyridine

1-pentylpiperidine
10324-58-0

1-pentylpiperidine

n-pentanethiol
110-66-7

n-pentanethiol

Conditions
Conditions Yield
With hydrogen sulfide; hydrogen; sulfidized Ni-W; at 300 ℃; for 5h; under 105008 Torr; Product distribution;
0.59 % Chromat.
3.59 % Chromat.
1-(4-nitrophenylthio)pyridinium chloride

1-(4-nitrophenylthio)pyridinium chloride

pyridine
110-86-1

pyridine

4-nitrobenzenesulfenyl chloride
937-32-6

4-nitrobenzenesulfenyl chloride

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
Conditions Yield
at 120 ℃; Product distribution;
62%
37%
65%
water
7732-18-5

water

1-(2,5-dibromo-4-hydroxy-3,6-dimethyl-benzyl)-pyridinium; bromide

1-(2,5-dibromo-4-hydroxy-3,6-dimethyl-benzyl)-pyridinium; bromide

pyridine
110-86-1

pyridine

2,5-dibromo-4-hydroxy-3,6-dimethyl-benzyl alcohol

2,5-dibromo-4-hydroxy-3,6-dimethyl-benzyl alcohol

hydrogen bromide
10035-10-6,12258-64-9

hydrogen bromide

Conditions
Conditions Yield
hydrogenchloride
7647-01-0,15364-23-5

hydrogenchloride

5-(4-nitro-anilino)-penta-2,4-dienal-(4-nitro-phenylimine); hydrobromide
29787-47-1

5-(4-nitro-anilino)-penta-2,4-dienal-(4-nitro-phenylimine); hydrobromide

pyridine
110-86-1

pyridine

2,3,5,6-tetrachlorobenzene-1,4-diol
87-87-6

2,3,5,6-tetrachlorobenzene-1,4-diol

4-nitro-aniline
100-01-6,104810-17-5

4-nitro-aniline

Conditions
Conditions Yield
at 180 ℃;
1-(4-nitrophenyloxythiocarbonyl)pyridinium chloride

1-(4-nitrophenyloxythiocarbonyl)pyridinium chloride

pyridine
110-86-1

pyridine

carbon oxide sulfide
463-58-1

carbon oxide sulfide

Conditions
Conditions Yield
With phosphate buffer; potassium chloride; In water; at 25 ℃; pH=6.5; Further Variations:; pH-values; Kinetics;
Conditions
Conditions Yield
In gas; dissociation in the gas phase at various temp.;;
(E)-2-pyridylphenyl ketoxime
14178-31-5

(E)-2-pyridylphenyl ketoxime

pyridine
110-86-1

pyridine

[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

2-(2'-pyridyl)benzoxazole
32959-62-9

2-(2'-pyridyl)benzoxazole

benzonitrile
100-47-0

benzonitrile

Conditions
Conditions Yield
at 800 ℃; for 8.33333E-06h; under 0.001 Torr; Further byproducts given;
77%
20%
12%
11%
3-Methylpyridine
108-99-6

3-Methylpyridine

pyridine
110-86-1

pyridine

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

nicotinic acid
59-67-6

nicotinic acid

Conditions
Conditions Yield
With vanadia-titania catalyst; at 250 ℃; under 760.051 Torr; Reagent/catalyst; Mechanism; Gas phase; Flow reactor;

Global suppliers and manufacturers

Global( 131) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Aecochem Corp.
  • Business Type:Manufacturers
  • Contact Tel:+86-592 599 8717
  • Emails:sales@aecochemical.com
  • Main Products:70
  • Country:China (Mainland)
  • AmoyChem Co.,Ltd
  • Business Type:Other
  • Contact Tel:+86 592 605 1114
  • Emails:sales@amoychem.com
  • Main Products:45
  • Country:China (Mainland)
  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:80
  • Country:China (Mainland)
  • Career Henan Chemical Co
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-371-86658258
  • Emails:purchase@coreychem.com
  • Main Products:137
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 110-86-1
close
Remarks: The blank with*must be completed
  • ©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
  • [Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer