110128-43-3Relevant articles and documents
Modular Cyclopentenone Synthesis through the Catalytic Molecular Shuffling of Unsaturated Acid Chlorides and Alkynes
Lee, Yong Ho,Denton, Elliott H.,Morandi, Bill
supporting information, p. 20948 - 20955 (2020/12/21)
We describe a general strategy for the intermolecular synthesis of polysubstituted cyclopentenones using palladium catalysis. Overall, this reaction is achieved via a molecular shuffling process involving an alkyne, an α,β-unsaturated acid chloride, which serves as both the alkene and carbon monoxide source, and a hydrosilane to create three new C-C bonds. This new carbon monoxide-free pathway delivers the products with excellent yields. Furthermore, the regioselectivity is complementary to conventional methods for cyclopentenone synthesis. In addition, a set of regio- and chemodivergent reactions are presented to emphasize the synthetic potential of this novel strategy.
Discovery of a novel lead structure for anti-malarials
Wiesner, Jochen,Wi?ner, Pia,Dahse, Hans-Martin,Jomaa, Hassan,Schlitzer, Martin
, p. 785 - 792 (2007/10/03)
From a library of 61 compounds available from former studies, 2,5-bis-acylaminobenzophenone 1 was identified as a lead structure for a novel class of anti-malaria agents active against multi-resistant Plasmodium falciparum strain Dd2. Some structural modifications of this initial lead demonstrated the potential for further improvement of the anti-plasmodial activity of this novel class of anti-malarials. Copyright
Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives
Watanabe,Hayashi,Yoshimatsu,Sakai,Takeyama,Takashima
, p. 50 - 59 (2007/10/02)
More than 110 derivatives of alkoxycinnamic acids were synthesized and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, α-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were
