110464-72-7

Basic information

• Product Name: 4-methoxy-3,5-dimethylpicolinaldehyde
• Synonyms: 4-methoxy-3,5-dimethylpicolinaldehyde
• CAS NO: 110464-72-7
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.191
• EINECS: -0
• Mol File: 110464-72-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 271.4 °C at 760 mmHg
• Flash Point: 117.9 °C
• Appearance: /
• Density: 1.094 g/cm³
• Vapor Pressure: 0.00648mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: 2-8°C
• PKA: 5.26±0.10(Predicted)
• CAS DataBase Reference: 4-methoxy-3,5-dimethylpicolinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-3,5-dimethylpicolinaldehyde(110464-72-7)
• EPA Substance Registry System: 4-methoxy-3,5-dimethylpicolinaldehyde(110464-72-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 110464-72-7(Hazardous Substances Data)

Usage

General Description

4-methoxy-3,5-dimethylpicolinaldehyde is a chemical compound with the molecular formula C12H13NO2. It is a yellow to brown solid and is commonly used in the pharmaceutical and research industries. 4-methoxy-3,5-dimethylpicolinaldehyde is known for its ability to form coordination complexes with metal ions, making it valuable in the field of coordination chemistry. It also has potential applications in organic synthesis and as a building block for the production of various aromatic compounds. Additionally, 4-methoxy-3,5-dimethylpicolinaldehyde may have biological activity and has been studied for its potential pharmacological uses. Overall, this chemical compound has diverse uses and is of interest in various scientific and industrial applications.

InChI:InChI=1/C9H11NO2/c1-6-4-10-8(5-11)7(2)9(6)12-3/h4-5H,1-3H3

Upstream product

• 86604-78-6 (4-methoxy-3,5-dimethylpyridin-2-yl)methanol 
• 84006-10-0 (chloromethyl)-4-methoxy-3,5-dimethylpyridine 

Downstream Products

• 104916-41-8 3,5-dimethyl-4-methoxy-2-cyanopyridine 
• 1196886-19-7 2-amino-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol 
• 1196886-17-5 7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidin-4-ol 
• 1196886-14-2 4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylsulfonyl)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine 
• 1196886-12-0 4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine 
• 1196886-10-8 (E)-N-(4-(benzyloxy)-6-chloro-2-(methylthio)pyrimidin-5-yl)-N-(3-(4-methoxy-3,5-dimethylpyridin-2-yl)allyl)-4-methylbenzenesulfonamide 
• 212779-06-1 3-(4-Methoxy-3,5-dimethyl-pyridin-2-yl)-propionaldehyde 

Relevant articles and documents

A Simple, Mild and General Oxidation of Alcohols to Aldehydes or Ketones by SO2F2/K2CO3 Using DMSO as Solvent and Oxidant

A practical, general and mild oxidation of primary and secondary alcohols to carbonyl compounds proceeds in yields of up to 99% using SO2F2 as electrophile in DMSO as both the oxidant and the solvent at ambient temperature. No moisture- and oxygen-free conditions are required. Stoichiometric amount of inexpensive K2CO3, which generates easy to separate by-products, is used as the base. Thus, 5-gram scale runs proceeded in nearly quantitative yields by a simple filtration as the work-up. The use of a polar solvent such as DMSO, which usually promotes competing Pummerer rearrangement, is also noteworthy. This protocol is compatible with a variety of common N-, O-, and S-functional groups on (hetero)arene, alkene and alkyne substrates (68 examples). The protocol was applied (99% yield) to a formal synthesis of the important cholesterol-lowering drug Rosuvastatin. (Figure presented.).

A catalytic oxidation heterocyclic aromatic primary alcohol for the preparation of heterocyclic aromatic aldehyde

The invention provides a method for preparing heterocyclic aromatic aldehyde by catalytically oxidizing heterocyclic aromatic primary alcohol. The method takes dioxovanadium nitrate as a catalyst and air as an oxidant; under a normal pressure condition, the heterocyclic aromatic primary alcohol is high-selectively oxidized into the heterocyclic aromatic aldehyde. The method provided by the invention has a high oxidization yield and a byproduct is water, so that the method is green, economical and environment-friendly; reaction conditions are moderate and the operation is simple. A catalysis system takes the air as the oxidant and non-metal metal as a catalyst, reaction conditions are moderate and the oxidization efficiency is high; the catalysis system is green and economical and can be used for efficiently catalyzing the heterocyclic aromatic primary alcohol into the corresponding heterocyclic aromatic aldehyde. Compared with a noble metal catalysis system and a catalysis system containing nitrogen-oxygen free radicals, the catalysis system has low oxidization reaction cost and has very high application value.

AMINE COMPOUNDS AND USE THEREOF

It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1):In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(=O) or NR11; and D is a group represented by the following general formula (4) or (6).-Q-Y-BIn the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.