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11116-32-8

Bleomycin A5 is a member of the class of bleomycins, which are a group of anti-cancer drugs derived from the bacterium Streptomyces verticillus. It is characterized by its ability to bind to DNA, causing single-strand and double-strand breaks, which ultimately leads to cell death. This property makes it a potent pharmaceutical candidate for various applications.

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  • 11116-32-8 Structure

  • Basic information

    1. Product Name: Bleomycin A5
    2. Synonyms: N1-(3-((4-Aminobutyl)amino)propyl)bleomycinamide;Pingyangmycin A5;Zhengguanmycin A5;Nsc350895;Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-;bleomycetin;Bleomycin A5
    3. CAS NO:11116-32-8
    4. Molecular Formula: C57H89N19O21S2
    5. Molecular Weight: 1440.57
    6. EINECS: 234-357-0
    7. Product Categories: N/A
    8. Mol File: 11116-32-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: 1.1028 (rough estimate)
    6. Refractive Index: 1.6700 (estimate)
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 10.84±0.46(Predicted)
    10. CAS DataBase Reference: Bleomycin A5(CAS DataBase Reference)
    11. NIST Chemistry Reference: Bleomycin A5(11116-32-8)
    12. EPA Substance Registry System: Bleomycin A5(11116-32-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 11116-32-8(Hazardous Substances Data)

11116-32-8 Usage

Uses

Used in Anticancer Applications:
Bleomycin A5 is used as an anticancer agent for the treatment of various types of solid malignancies, including cervicofacial lymphatic malformations. It works by binding to DNA and causing strand breaks, which inhibits DNA replication and transcription, leading to cell death. This mechanism of action makes it an effective treatment option for cancer patients.
Used in Sclerotherapy:
In the medical field of sclerotherapy, Bleomycin A5 is used as a sclerosant agent for the treatment of cervicofacial lymphatic malformations. It is injected into the affected area to cause the targeted blood vessels or lymphatic vessels to collapse and eventually be reabsorbed by the body, reducing the size of the malformation and alleviating associated symptoms.

Check Digit Verification of cas no

The CAS Registry Mumber 11116-32-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,1,1 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 11116-32:
(7*1)+(6*1)+(5*1)+(4*1)+(3*6)+(2*3)+(1*2)=48
48 % 10 = 8
So 11116-32-8 is a valid CAS Registry Number.
InChI:InChI=1/C61H89N19O21S2/c1-25-39(77-52(80-50(25)64)31(17-37(63)84)72-18-30(62)51(65)90)56(94)79-41(47(32-19-68-24-73-32)99-60-49(45(88)43(86)35(20-81)98-60)100-59-46(89)48(101-61(66)96)44(87)36(21-82)97-59)57(95)74-27(3)42(85)26(2)53(91)78-40(28(4)83)55(93)71-16-11-38-75-34(23-102-38)58-76-33(22-103-58)54(92)70-15-8-13-67-12-7-10-29-9-5-6-14-69-29/h5-6,9,14,19,22-24,26-28,30-31,35-36,40-49,59-60,67,72,81-83,85-89H,7-8,10-13,15-18,20-21,62H2,1-4H3,(H2,63,84)(H2,65,90)(H2,66,96)(H,68,73)(H,70,92)(H,71,93)(H,74,95)(H,78,91)(H,79,94)(H2,64,77,80)/t26-,27+,28+,30-,31-,35?,36?,40-,41-,42-,43?,44?,45?,46?,47-,48?,49?,59?,60?/m0/s1

11116-32-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name bleomycin A5

1.2 Other means of identification

Product number -
Other names bleomycetin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:11116-32-8 SDS

11116-32-8Upstream product

11116-32-8Downstream Products

11116-32-8Related news

A clinical study of ultrasound-guided intralesional injection of Bleomycin A5 (cas 11116-32-8) on venous malformation in cervical-facial region in China07/22/2019

ObjectivesTo evaluate the therapeutic outcome of ultrasound-guided intralesional injection of bleomycin A5 on treatment of venous malformation (VM) in cervical-facial region.detailed

Electrophoresis mobility shift assay and biosensor used in studying the interaction between Bleomycin A5 (cas 11116-32-8) and DNA07/20/2019

DNA is the potential target of numerous drugs utilized widely in clinical cancer therapy. Here we employed bleomycin A5, with its deactivated form as contrast, to investigate the interaction between small pharmaceutical and DNA. Electrophoresis mobility shift assay (EMSA) which is a common techn...detailed

Bleomycin A5 (cas 11116-32-8) plus dexamethasone for control of growth in infantile parotid hemangiomas07/21/2019

ObjectiveThe purpose of this study was to evaluate the efficacy of bleomycin A5 (pingyangmycin) plus dexamethasone for control of growth in infantile parotid hemangiomas.detailed

Bleomycin A5 (cas 11116-32-8) sclerotherapy for cervicofacial lymphatic malformations07/19/2019

ObjectivesThe purpose of this study was to document the results of bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations (LMs), and the clinical data of 65 patients between October 2004 and October 2007 were reviewed.detailed

How to use Bleomycin A5 (cas 11116-32-8) for infantile maxillofacial haemangiomas: Clinical evaluation of 82 consecutive cases07/18/2019

ObjectiveBleomycin A5 has been reported effective for infantile haemangioma (IH), but the usage and complications were described a little. We have used bleomycin A5 to treat maxillofacial IHs for 15 years. This paper describes the procedures to use bleomycin A5 and avoid its complications based ...detailed

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