112-85-6

Basic information

• Product Name: Docosanoic acid
• Synonyms: 1-Docosanoic acid;1-docosanoicacid;B95;B95(acid);behenic;Behensαure;docosanoic;Docosansαure
• CAS NO: 112-85-6
• Molecular Formula: C₂₂H₄₄O₂
• Molecular Weight: 340.58
• EINECS: 204-010-8
• Product Categories: Saturated Higher Fatty Acids;Alkylcarboxylic Acids;Biochemistry;Color Former & Related Compounds;Functional Materials;Higher Fatty Acids & Higher Alcohols;Monofunctional & alpha,omega-Bifunctional Alkanes;Monofunctional Alkanes;Sensitizer
• Mol File: 112-85-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 72-80 °C(lit.)
• Boiling Point: 306°C 60mm
• Flash Point: 306°C/60mm
• Appearance: White to slightly yellow/Crystalline Powder
• Density: d4100 0.8221
• Vapor Pressure: 7.66E-07mmHg at 25°C
• Refractive Index: nD100 1.4270
• Storage Temp.: 2-8°C
• Solubility: chloroform: soluble50mg/mL, clear
• PKA: 4.78±0.10(Predicted)
• Water Solubility: Soluble in DMF (~3 mg/ml), hot methanol, water (0.15 mg/ml at 25°C), chloroform, and ethanol (2.18 mg/ml at 25°C).
• Stability: Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents.
• Merck: 14,1023
• BRN: 1792887
• CAS DataBase Reference: Docosanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Docosanoic acid(112-85-6)
• EPA Substance Registry System: Docosanoic acid(112-85-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• TSCA: Yes
• Hazardous Substances Data: 112-85-6(Hazardous Substances Data)

Usage

Chemical Properties

white to cream crystals or powder

Uses

Different sources of media describe the Uses of 112-85-6 differently. You can refer to the following data:
1. Docosanoic acid is a long-chain fatty acid,it has the following purposes: Waxes, textiles, pharmaceuticals, emulsifiers, and personal care products, lubricants, esters, chemical synthesis, and specialties.
2. behenic acid is a long-chain fatty acid used in product formulations to form a viscous emulsion. It is considered a non-comedogenic raw material.
3. Behenic acid is used to give hair conditioners and moisturizers their smoothing properties. It is also used to investigate the phase behavior of long-chain acids in supercritical propane.

Definition

ChEBI: A straight-chain, C22, long-chain saturated fatty acid.

General Description

Monomolecular films of stearic and behenic acid were formed on substrates 0.1M in sodium chloride, sodium bicarbonate or sodium phosphate and were investigated by IR analysis.

Flammability and Explosibility

Nonflammable

Purification Methods

Crystallise the acid pKEst from ligroin. [Francis & Piper J Am Chem Soc 61 577 1939, Beilstein 2 IV 1290.]

InChI:InChI=1/C22H44O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h2-21H2,1H3,(H,23,24)

Synthetic route

linoleic acid (60-33-3) → n-docosanoic acid (112-85-6)

Conditions	Yield
With hydrogen In methanol at 20℃; for 4h;	97.5%

cis-13-docosenoic acid (112-86-7) → n-docosanoic acid (112-85-6)

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 20 - 30℃; under 4500.45 - 6000.6 Torr;	90.3%
bei der Reduktion an platinierten Platinkathoden.Electrolysis;
With selenium at 300℃;

6-docosenoic acid (116802-23-4) → n-docosanoic acid (112-85-6)

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol for 6h;	86%

(Z)-docos-11-enoic acid (1002-96-6) → n-docosanoic acid (112-85-6)

Conditions	Yield
With ethanol; platinum Hydrogenation;

Brassidic acid (506-33-2) → n-docosanoic acid (112-85-6)

Conditions	Yield
With hydrogen; nickel Hydrogenation;

n-triacontane (638-68-6) → n-docosanoic acid (112-85-6)

Conditions	Yield
With air at 95℃;

5-oxo-docosanoic acid (115097-02-4) → n-docosanoic acid (112-85-6)

Conditions	Yield
With methanol; sodium; hydrazine; diethylene glycol at 195℃;

6-oxo-docosanoic acid → n-docosanoic acid (112-85-6)

Conditions	Yield
With potassium hydroxide; hydrazine hydrate; diethylene glycol

4-oxodocosanoic acid (115097-01-3) → n-docosanoic acid (112-85-6)

Conditions	Yield
With sodium hydroxide; hydrazine hydrate; diethylene glycol at 220℃;

(4E,8E,12E,15E,19E)-Docosa-4,8,12,15,19-pentaenoic acid (2548-85-8) → n-docosanoic acid (112-85-6)

Conditions	Yield
Hydrogenation;

adipic acid monomethyl ester (627-91-8) + stearic acid (57-11-4) → n-docosanoic acid (112-85-6)

Conditions	Yield
With methanol; sodium Electrolysis.und Behandlung des Reaktionsprodukts mit methanol.Natronlauge;

behenic acid methyl ester (929-77-1) → n-docosanoic acid (112-85-6)

Conditions	Yield
With potassium hydroxide

1-octyl docosanoate (5979-98-6) → octanol (111-87-5) + n-docosanoic acid (112-85-6)

Conditions	Yield
With potassium hydroxide In methanol for 3h; Heating;	A 5 mg B 10 mg

docosanoic acid nicotinamide complex → n-docosanoic acid (112-85-6) + nicotinamide (98-92-0)

Conditions	Yield
With pH 1.2 In water at 37℃; Product distribution; var. pH and temperatures;

17-hydroxy-13,14-dihydrokolavenol behenate → n-docosanoic acid (112-85-6) + 17-hydroxy-13,14-dihydrokolavenol

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; methanol at 70℃; for 3h; Yield given;

μ-bromo-behenic acid → n-docosanoic acid (112-85-6)

Conditions	Yield
With water; zinc at 130℃;

ν-bromo-behenic acid → n-docosanoic acid (112-85-6)

Conditions	Yield
With water; zinc at 130℃;

5-oxo-heneicosane-carboxylic acid-(1) → n-docosanoic acid (112-85-6)

Conditions	Yield
With sodium hydroxide; hydrazine hydrate; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol zuletzt bei 200grad nach teilweisem Abdestillieren des Loesungsmittels;

9-oxo-heneicosane-carboxylic acid-(1) → n-docosanoic acid (112-85-6)

Conditions	Yield
With hydrogenchloride; amalgamated zinc

behenic acid nitrile → n-docosanoic acid (112-85-6)

Conditions	Yield
With sodium hydroxide

ethanol (64-17-5) + cis-13-docosenoic acid (112-86-7) + colloidal palladium → n-docosanoic acid (112-85-6)

Conditions	Yield
Hydrogenation;

iodobehenic acid → n-docosanoic acid (112-85-6)

Conditions	Yield
With hydrogenchloride; ethanol; zinc Verseifung etwa entstandenen Esters mit Kalilauge;

cis-13-docosenoic acid (112-86-7) + hydrogen + nickel pumice stone → n-docosanoic acid (112-85-6)

cis-13-docosenoic acid (112-86-7) + hydrogen + palladium → n-docosanoic acid (112-85-6)

paraffin → n-docosanoic acid (112-85-6)

Conditions	Yield
With oxygen at 150℃;
With Nitrogen dioxide at 120 - 130℃;

docosanoic acid anhydride (55726-23-3) + Fuller's earth + petroleum ether → n-docosanoic acid (112-85-6)

cis-13-docosenoic acid (112-86-7) + hydrogen iodide (10034-85-2) + phosphorus → n-docosanoic acid (112-85-6)

Conditions	Yield
at 200 - 210℃;

Brassidic acid (506-33-2) + hydrogen iodide (10034-85-2) + phosphorus → n-docosanoic acid (112-85-6)

Conditions	Yield
at 210℃;

ethanol (64-17-5) + (Z)-docos-11-enoic acid (1002-96-6) + platinum black → n-docosanoic acid (112-85-6)

Conditions	Yield
Hydrogenation;

n-docosanoic acid (112-85-6) + toluene (108-88-3) → 1-p-Tolyl-docosan-1-one (101493-90-7)

Conditions	Yield
Ce3+ exchanged Y-fanjasite at 150℃; for 48h;	100%

1-docosanol (661-19-8) + n-docosanoic acid (112-85-6) → docosyl docosanoate (17671-27-1)

Conditions	Yield
at 250℃; for 15h; Inert atmosphere;	99.6%
With C28H60O3PS(1+)*CF3O3S(1-) at 80℃; for 6h; Sealed tube;

n-docosanoic acid (112-85-6) → Docosanylamide (3061-75-4)

Conditions	Yield
Stage #1: n-docosanoic acid With oxalyl dichloride In toluene for 2h; Inert atmosphere; Reflux; Stage #2: With ammonium hydroxide In water	99%
With ammonia; zircornium(IV) n-propoxide at 165℃; for 7h; Reagent/catalyst;	98.7%
With phosphorus pentachloride at 160℃; man versetzt nach Entfernung des POCl3 mit konz.Ammoniak;
Multi-step reaction with 2 steps 1: SOCl2 / Heating 2: ammonia gas / CHCl3 View Scheme
Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane / Inert atmosphere 2: ammonium hydroxide View Scheme

n-docosanoic acid (112-85-6) + silver nitrate → silver docosanoate (2489-05-6)

Conditions	Yield
In ammonium hydroxide; ethanol hot (50°C) soln. docosanoic acid in EtOH was added slowly to hot soln. AgNO3 in aq. NH4OH at 50°C in the dark; ppt. was washed with water, extracted with EtOH and dried in vacuo for 12 h;	99%
In water dipping Langmuir-Blodgett film of behenic acid on CaF2 substrate into soln. of AgNO3, 15 min; washing with H2O, drying in air;

n-docosanoic acid (112-85-6) + Methyl 2,5-dihydroxybenzoate (2150-46-1) → methyl 5-(docosanoyloxy)-2-hydroxybenzoate

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 1h;	99%

n-docosanoic acid (112-85-6) → n-docosanal (57402-36-5)

Conditions	Yield
With methylphenylsilane; 2,2-dimethylpropanoic anhydride; Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium(0) In toluene at 60℃; for 20h; Schlenk technique; Inert atmosphere;	98%
Multi-step reaction with 2 steps 1: thionyl chloride / diethyl ether / 20 °C 2: bis(dibenzylideneacetone)-palladium(0); tris(2,4,6-trimethylphenyl)phosphine; triethylsilane / toluene / 1.5 h / 40 °C / Schlenk technique; Inert atmosphere View Scheme

1-octadecanol (112-92-5) + n-docosanoic acid (112-85-6) → stearyl behenate (24271-12-3)

Conditions	Yield
With triphenylphosphine-sulfur trioxide adduct In neat (no solvent) at 110℃; for 2h; Green chemistry;	97%
at 250℃; for 15h; Inert atmosphere;	92.8%

n-docosanoic acid (112-85-6) + H2N-Arg(Pbf)-Gly-Asp(OtBu)-OtBu (1314357-54-4) → C55H96N6O10S (1431949-35-7)

Conditions	Yield
Stage #1: n-docosanoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: H2N-Arg(Pbf)-Gly-Asp(OtBu)-OtBu In dichloromethane at 0 - 20℃; for 96h;	96%

n-docosanoic acid (112-85-6) + (2S)-2-amino-N-dodecyl-5-[(N-nitrocarbamimidoyl)amino]pentanamide hydrochloride → N-[(1S)-1-(dodecylcarbamoyl)-4-[(N-nitrocarbamimidoyl)amino]butyl]docosanamide

Conditions	Yield
Stage #1: n-docosanoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: (2S)-2-amino-N-dodecyl-5-[(N-nitrocarbamimidoyl)amino]pentanamide hydrochloride With triethylamine In tetrahydrofuran at 20℃;	96%

1-Tetradecanol (112-72-1) + n-docosanoic acid (112-85-6) → myristyl behenate (42233-09-0)

Conditions	Yield
With triphenylphosphine-sulfur trioxide adduct In neat (no solvent) at 110℃; for 2h; Green chemistry;	96%

n-docosanoic acid (112-85-6) → docosanoic acid anhydride (55726-23-3)

Conditions	Yield
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 0 - 20℃; for 24h;	95%
With acetic anhydride
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h; Acylation;
Multi-step reaction with 2 steps 1: 51 percent / N-methylmorpholine / tetrahydrofuran / 1.) 0 to 5 deg C, 24 h 2.) r.t., 14 h 2: CHCl3 View Scheme

1,3-dioxan-5-yl 4-methylbenzene-1-sulfonate (32061-16-8) + n-docosanoic acid (112-85-6) → docosanoic acid 3-hydroxy-2-(toluene-4-sulfonyloxy)-propyl ester

Conditions	Yield
With boron trifluoride diethyl etherate; trifluoroacetic anhydride In tetrahydrofuran at 20℃; for 2h; acylolysis;	95%

1-Hexadecanol (36653-82-4) + n-docosanoic acid (112-85-6) → palmityl behenate (42233-11-4)

Conditions	Yield
With choline chloride; zinc(II) chloride at 110℃; for 12h;	95%

n-docosanoic acid (112-85-6) + methyl 2,3-di-O-benzyl-β-D-arabinofuranosyl-(1->2)-3-O-benzyl-α-D-arabinofuranoside (1236193-41-1) → methyl 5-O-behenoyl-2,3-di-O-benzyl-β-D-arabinofuranosyl-(1->2)-5-O-behenoyl-3-O-benzyl-α-D-arabinofuranoside (1236193-48-8)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 4h; Inert atmosphere;	95%

n-docosanoic acid (112-85-6) + carbonic acid dimethyl ester (616-38-6) → behenic acid methyl ester (929-77-1)

Conditions	Yield
With triethylamine at 160℃; for 5h; Autoclave; Green chemistry;	95%
With diiron nonacarbonyl at 180℃; for 1h; Sealed tube;

n-docosanoic acid (112-85-6) + 1-O-palmitoyl-2-O-oleoyl glycerol (3123-73-7) → Docosanoic acid 3-hexadecanoyloxy-2-((Z)-octadec-9-enoyloxy)-propyl ester

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h; Esterification;	94%

n-docosanoic acid (112-85-6) + decanoic acid 3-hydroxy-2-(toluene-4-sulfonyloxy)-propyl ester (314266-01-8) → docosanoic acid 3-decanoyloxy-2-(toluene-4-sulfonyloxy)-propyl ester (314266-04-1)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h; Esterification;	94%

n-docosanoic acid (112-85-6) + hexadecanoic acid 3-hydroxy-2-(toluene-4-sulfonyloxy)-propyl ester (124866-91-7) → docosanoic acid 3-hexadecanoyloxy-2-(toluene-4-sulfonyloxy)-propyl ester (314266-05-2)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h; Esterification;	94%

n-docosanoic acid (112-85-6) → docosanoyl azide (58257-64-0)

Conditions	Yield
With sodium azide; N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride In dichloromethane; dimethyl sulfoxide at 0 - 20℃; for 0.5h;	94%
Stage #1: n-docosanoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at -20℃; for 0.5h; Stage #2: With sodium azide In tetrahydrofuran; water at -5℃; for 0.25h; Inert atmosphere;

n-docosanoic acid (112-85-6) → docosanoyl chloride (21132-76-3)

Conditions	Yield
With phosgene at 95℃; for 48h;	93.2%
With thionyl chloride
With thionyl chloride at 85℃;

n-docosanoic acid (112-85-6) + 1-amino-3-(dimethylamino)propane (109-55-7) → N-(3-(dimethylamino)propyl)docosanamide (60270-33-9)

Conditions	Yield
With aluminum oxide; sodium fluoride at 165℃; for 11h; Inert atmosphere;	92.41%
at 150 - 180℃; for 10.5h;
Amidation;

n-docosanoic acid (112-85-6) + (2S,3R,4R)-2-amino-1,4-di-O-benzyl-3-O-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyl)octadecane (321734-99-0) → (2S,3R,4R)-1,4-di-O-benzyl-3-O-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyl)-2-N-docosanoyl-octadecane (321735-01-7)

Conditions	Yield
Stage #1: (2S,3R,4R)-2-amino-1,4-di-O-benzyl-3-O-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyl)octadecane With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0℃; for 0.5h; activation; Stage #2: n-docosanoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h; Acylation;	92%

(L)-2-hydroxy-1-hexadecyloxycarbonylethylammonium chloride + n-docosanoic acid (112-85-6) → N-docosanoyl-(L)-serine hexadecyl ester

Conditions	Yield
Stage #1: (L)-2-hydroxy-1-hexadecyloxycarbonylethylammonium chloride With dmap In chloroform Stage #2: n-docosanoic acid With dicyclohexyl-carbodiimide In chloroform at 20℃; for 20h;	92%

chlorosulfuric acid chloromethyl ester (49715-04-0) + n-docosanoic acid (112-85-6) → docosanoic acid chloromethyl ester

Conditions	Yield
Stage #1: n-docosanoic acid With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane; water at 20℃; Stage #2: chlorosulfuric acid chloromethyl ester In dichloromethane; water at 0℃; for 18h;	92%

n-docosanoic acid (112-85-6) + aniline (62-53-3) → docosananilide (82052-48-0)

Conditions	Yield
With chloroformic acid ethyl ester; triethylamine In dichloromethane for 0.5h; Ambient temperature;	90%

n-docosanoic acid (112-85-6) + (2S,3R,4R)-2-amino-1,4-di-O-benzyl-3-O-(2',3',4',6'-tetra-O-benzyl-β-D-galactopyranosyl)octadecane (321734-98-9) → (2S,3R,4R)-1,4-di-O-benzyl-3-O-(2',3',4',6'-tetra-O-benzyl-β-D-galactopyranosyl)-2-N-docosanoyl-octadecane (321735-00-6)

Conditions	Yield
Stage #1: (2S,3R,4R)-2-amino-1,4-di-O-benzyl-3-O-(2',3',4',6'-tetra-O-benzyl-β-D-galactopyranosyl)octadecane With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0℃; for 0.5h; activation; Stage #2: n-docosanoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h; Acylation;	90%

n-docosanoic acid (112-85-6) + (2S,3R,4R)-2-amino-3,4-di-O-benzyl-1-O-(2',3',4',6'-tetra-O-benzyl-α-D-galactopyranosyl)octadecane (321734-88-7) → (2S,3R,4R)-3,4-di-O-benzyl-1-O-(2',3',4',6'-tetra-O-benzyl-α-D-galactopyranosyl)-2-N-docosanoyl-octadecane (321734-90-1)

Conditions	Yield
Stage #1: (2S,3R,4R)-2-amino-3,4-di-O-benzyl-1-O-(2',3',4',6'-tetra-O-benzyl-α-D-galactopyranosyl)octadecane With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0℃; for 0.5h; activation; Stage #2: n-docosanoic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h; Acylation;	90%

2,6-Diaminopyridine (141-86-6) + n-docosanoic acid (112-85-6) → N-(6-aminopyridin-2-yl)docosanamide

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 22h;	90%

Upstream product

• 1002-96-6 (Z)-docos-11-enoic acid 
• 112-86-7 cis-13-docosenoic acid 
• 506-33-2 Brassidic acid 
• 638-68-6 n-triacontane 
• 627-91-8 adipic acid monomethyl ester 
• 57-11-4 stearic acid 
• 64-17-5 ethanol 
• 55726-23-3 docosanoic acid anhydride 
• 10034-85-2 hydrogen iodide 
• 60-29-7 diethyl ether 
• 7647-01-0 hydrogenchloride 
• 801980-02-9 13-iodo-docosanoic acid 
• 115097-03-5 13-bromo-docosanoic acid 
• 7732-18-5 water 

Downstream Products

• 929-77-1 behenic acid methyl ester 
• 5908-87-2 ethyl docosanoate 
• 3061-75-4 Docosanylamide 
• 21132-76-3 docosanoyl chloride 
• 20828-43-7 α-bromobehenic acid 
• 591-71-9 22-tritetracontanone 
• 55726-23-3 docosanoic acid anhydride 
• 138621-85-9 1-(4-bromo-phenyl)-2-docosanoyloxy-ethanone 
• 856360-21-9 1-(2,4-dihydroxy-phenyl)-docosan-1-one 
• 26720-37-6 hexyl docosanoate 
• 3539-32-0 propylene glycol monobehenate 
• 101493-91-8 1-(2,5-dimethylphenyl)-1-docosanone 
• 111130-95-1 Docosanoic acid 4-benzyloxy-phenyl ester 
• 321735-01-7 (2S,3R,4R)-1,4-di-O-benzyl-3-O-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyl)-2-N-docosanoyl-octadecane 

Related news

Contact angles and transfer ratios measured during the Langmuir-Blodgett deposition of Docosanoic acid (cas 112-85-6) onto mica from CdCl2 subphases07/14/2019

The Langmuir-Blodgett deposition of monolayers of docosanoic acid from aqueous subphases containing 2.5 × 10−4 M CdCl2 has been studied in detail as a function of pH. We have measured the force exerted on freshly cleaved mica substrates during transfer, enabling the dynamic contact angle to be ...detailed

Dynamic contact angles and deposition efficiency for transfer of Docosanoic acid (cas 112-85-6) on to mica from CdCl2 subphases as a function of pH07/13/2019

We describe results for the dynamic contact angle and transfer ratio for the deposition of docosanoic acid monolayers on to mica from CdCl2 subphases as a function of pH. The deposition changes from Z to Y type at approximately the pH corresponding to half ionisation. Deposition on OUT strokes o...detailed

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A PROCESS FOR THE PREPARATION OF DOCOSANOL

The present invention provides a process for the preparation of Docosanol (I). The process comprises reducing cis-13-Docosenoic acid (V) to obtain Docosanoic acid (III), which is further reduced to obtain Docosanol (I).

Process

A process for producing a conjugated di- or poly-unsaturated fatty acid having from 12 to 24 carbon atoms, or a salt or ester thereof, comprises reacting a non-conjugated free fatty acid, or a salt or ester thereof with a base in the presence of a solvent comprising a monohydric alcohol having from 1 to 6 carbon atoms, wherein the reaction is carried out at a temperature of from 120° C. to 200° C. in the presence of water in an amount of at least 4% by weight based on alcohol.