1121599-93-6Relevant articles and documents
Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression
Song, Jiho,Kim, Young Jin,Min, Kyung Hoon,Lee, Hyun-E,Kim, Su Yeon,Kim, Dong-Seok
, p. 6943 - 6946,4 (2012)
5,6,7,8-Tetrahydro-4H-cyclohepta[d]isoxazole derivatives were synthesized and evaluated as a novel class of inhibitors for α-melanocyte-stimulating hormone (α-MSH) induced melanogenesis in a mouse melanoma B16F10 cell line. Compound 8e (IC50 = 0.67 μM), 8h (IC50 = 1.01 μM) and 9b (IC50 = 0.99 μM) exhibited a potent inhibitory activity approximately 85- to 126-fold greater than kojic acid, a well-known potent inhibitor. A biochemical study indicates that the activity of this series should be displayed via down-regulation of the expression of tyrosinase.