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1121599-93-6

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1121599-93-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1121599-93-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,2,1,5,9 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1121599-93:
(9*1)+(8*1)+(7*2)+(6*1)+(5*5)+(4*9)+(3*9)+(2*9)+(1*3)=146
146 % 10 = 6
So 1121599-93-6 is a valid CAS Registry Number.

1121599-93-6Relevant articles and documents

Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression

Song, Jiho,Kim, Young Jin,Min, Kyung Hoon,Lee, Hyun-E,Kim, Su Yeon,Kim, Dong-Seok

, p. 6943 - 6946,4 (2012)

5,6,7,8-Tetrahydro-4H-cyclohepta[d]isoxazole derivatives were synthesized and evaluated as a novel class of inhibitors for α-melanocyte-stimulating hormone (α-MSH) induced melanogenesis in a mouse melanoma B16F10 cell line. Compound 8e (IC50 = 0.67 μM), 8h (IC50 = 1.01 μM) and 9b (IC50 = 0.99 μM) exhibited a potent inhibitory activity approximately 85- to 126-fold greater than kojic acid, a well-known potent inhibitor. A biochemical study indicates that the activity of this series should be displayed via down-regulation of the expression of tyrosinase.

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