1124-54-5

Basic information

• Product Name: Carbamic acid cyclohexyl ester
• Synonyms: Carbamic acid cyclohexyl ester
• CAS NO: 1124-54-5
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 0
• Mol File: 1124-54-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 267.6°C at 760 mmHg
• Flash Point: 136.2°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 0.00808mmHg at 25°C
• Refractive Index: 1.478
• CAS DataBase Reference: Carbamic acid cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid cyclohexyl ester(1124-54-5)
• EPA Substance Registry System: Carbamic acid cyclohexyl ester(1124-54-5)

Safety Data

• Hazardous Substances Data: 1124-54-5(Hazardous Substances Data)

Usage

General Description

Carbamic acid cyclohexyl ester is a chemical compound with the molecular formula C8H15NO2. It is also known as cyclohexyl carbamate and is used as a solvent in the production of pharmaceuticals and pesticides. It is a colorless to light yellow liquid with a mild, characteristic odor. Carbamic acid cyclohexyl ester is considered to be relatively stable, especially under normal storage conditions. However, it is important to handle this compound with care as it may be harmful if inhaled, swallowed, or comes in contact with the skin and eyes. Additionally, it can react with strong oxidizing agents and is incompatible with acids, bases, and other reactive chemicals.

InChI:InChI=1/C7H13NO2/c8-7(9)10-6-4-2-1-3-5-6/h6H,1-5H2,(H2,8,9)

Upstream product

• 917-61-3 sodium isocyanate 
• 108-93-0 cyclohexanol 
• 590-28-3 potassium cyanate 
• 90454-50-5 N-ethoxycarbonyl-(2,3,4,5-tetrachloro-1-thiophenio)amide 
• 13248-54-9 cyclohexyl chloroformate 
• 57-13-6 urea 

Downstream Products

• 41142-08-9 (4-Chloro-benzenesulfonyl)-cyclohexyloxycarbonylamino-acetic acid 
• 41142-21-6 (4-Acetylamino-benzenesulfonyl)-cyclohexyloxycarbonylamino-acetic acid 
• 41194-35-8 Cyclohexyloxycarbonylamino-(2,5-dichloro-benzenesulfonyl)-acetic acid 
• 41142-30-7 Cyclohexyloxycarbonylamino-(3,4,5-trimethoxy-benzenesulfonyl)-acetic acid 
• 106672-45-1 erythro-cyclohexyl <1-butyl-2-(phenylseleno)hexyl>carbamate 
• 1298016-45-1 C₇H₁₁Cl₂NO₂ 
• 3770-95-4 O-cyclohexyl N-phenylcarbamate 
• 126260-83-1 (4R,5R)-5-(3-Benzyloxy-propyl)-4-methyl-oxazolidine-3-carboxylic acid cyclohexyl ester 
• 126260-83-1 (4R,5S)-5-(3-Benzyloxy-propyl)-4-methyl-oxazolidine-3-carboxylic acid cyclohexyl ester 
• 126260-88-6 (4S,5S)-5-[2-(2-Dodecyl-[1,3]dioxolan-2-yl)-ethyl]-4-methyl-oxazolidine-3-carboxylic acid cyclohexyl ester 
• 126260-85-3 (4R,5R)-4-Methyl-5-(3-oxo-pentadecyl)-oxazolidine-3-carboxylic acid cyclohexyl ester 
• 126260-86-4 (4R,5R)-5-(3-Hydroxy-pentadecyl)-4-methyl-oxazolidine-3-carboxylic acid cyclohexyl ester 
• 126260-81-9 (4-Benzyloxy-1-vinyl-butoxymethyl)-carbamic acid cyclohexyl ester 
• 126260-84-2 (4R,5R)-4-Methyl-5-(3-oxo-propyl)-oxazolidine-3-carboxylic acid cyclohexyl ester 

Relevant articles and documents

Silica supported perchloric acid (HClO4-SiO2): an efficient reagent for the preparation of primary carbamates under solvent-free conditions

The synthesis of primary carbamates from structurally diverse compounds containing a hydroxyl group has been performed in high yields and purity, and without any epimerization under solvent-free conditions using HClO4-SiO2 as a mild, convenient, and effective reagent. The procedure is operationally simple, efficient, and environmentally benign.

Indium(III)-Catalyzed Synthesis of Primary Carbamates and N-Substituted Ureas

An indium triflate-catalyzed synthesis of primary carbamates from alcohols and urea as an ecofriendly carbonyl source has been developed. Various linear, branched, and cyclic alcohols were converted into the corresponding carbamates in good to excellent yields. This method also provided access to N-substituted ureas by carbamoylation of amines. All the products were obtained by simple filtration or crystallization, without the need for chromatographic purification. Mechanistic investigations suggest that the carbamoylation reaction proceeds through activation of urea by O-coordination with indium, followed by nucleophilic attack by the alcohol or amine on the carbonyl center of urea. The inexpensive and easily available starting materials and catalyst, the short reaction times, and the ease of product isolation highlight the inherent practicality of the developed method.

Selective Synthesis of Secondary Arylcarbamates via Efficient and Cost Effective Copper-Catalyzed Mono Arylation of Primary Carbamates with Aryl Halides and Arylboronic Acids

Abstract: An efficient, selective and cost-effective procedure has been developed for mono N-arylation of primary alkyl and benzyl carbamates with aryl iodides and bromides by incorporating CuI as an inexpensive and commercially available catalyst. Despite previous reports on C–N coupling reactions, this process does not need expensive ligands and takes advantage of readily available and inexpensive ethylenediamine (EDA) as the ligand. Reaction times were relatively short and related N-arylated carbamates were obtained in excellent yields. Interestingly, replacing CuI with Cu(OAc)2 allowed us to use arylboronic acids as coupling partner for this reaction. All products are well characterized by 1H- and 13C-NMR, MS, melting point, IR and CHNS techniques.