112677-05-1Relevant articles and documents
[2+2] Cycloaddition of electron-poor acetylenes to (E)-3-dimethylamino-1-heteroaryl-prop-2-en-1-ones: synthesis of highly functionalized 1-heteroaroyl-1,3-butadienes
Bezen?ek, Jure,Kole?a, Tanja,Gro?elj, Uro?,Wagger, Jernej,Stare, Katarina,Meden, Anton,Svete, Jurij,Stanovnik, Branko
, p. 3392 - 3397 (2010)
Microwave-assisted [2+2] cycloaddition of (E)-3-dimethylamino-1-heteroaryl-prop-2-en-1-ones to dimethyl acetylenedicarboxylates gives (2E,3E)-dimethyl-2-[(dimethylamino)methylene]-3-(substituted)succinates in 8-91% yield. In the case of a 4,5-dihydrothiazoline derivative, cycloaddition also took place at the endocyclic C{double bond, long}N double bond.
Pyrimidine phenmethyl different hydroxy wo acid histone deacetylase inhibitors and preparation method and application
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Paragraph 0085; 0086, (2017/08/26)
The invention discloses a pyrimidine benzyl hydroxamic acid histone deacetylase inhibitor, and a preparation method and application thereof. The compound has the structure shown as general formula I. The compound provided by the invention has relatively high inhibiting activity on histone deacetylases, and can be used for preparing medicaments for preventing or treating related mammalian diseases caused by abnormal expression of the histone deacetylases. The invention further relates to the pharmaceutical application of the compound with the structure shown as the general formula I.
First examples of 2,6-diarylnicotinaldehydes prepared under conventional and microwave conditions
Shankaraiah,Chandrasekhar,Siva Nagi Reddy,Sabitha, Gowravaram
, p. 842 - 846 (2015/03/04)
Enaminoketones undergo unexpected self condensation in acetic acid to produce a wide range of 2,3,6-trisubstituted pyridine derivatives in excellent yields in the presence of NH4OAc. This is the first Letter on the synthesis of 2,6-diarylnicoti