112755-94-9

Basic information

• Product Name: C₁₃H₂₀O₃
• CAS NO: 112755-94-9
• Molecular Weight: 224.3
• Mol File: 112755-94-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: C₁₃H₂₀O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₂₀O₃(112755-94-9)
• EPA Substance Registry System: C₁₃H₂₀O₃(112755-94-9)

Safety Data

• Hazardous Substances Data: 112755-94-9(Hazardous Substances Data)

Upstream product

• 74513-16-9 bicyclo[3.3.0]octane-3,7-dione 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 92007-38-0 cis-bicyclo[3.3.0]octane-3,7-dione 3,7-bis(2',2'-dimethylpropylidene) acetal 
• 51716-63-3 cis-bicyclo[3. 3. 0]octane-3,7-dione 

Downstream Products

• 210296-16-5 Acetic acid (2R,3R,3aS,6aS)-3-((E)-(R)-3-acetoxy-oct-1-enyl)-5-[5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-1,2,3,3a,4,6a-hexahydro-pentalen-2-yl ester 
• 210296-15-4 Acetic acid (2R,3R,3aS,6aS)-3-((E)-(R)-1-acetoxy-oct-2-enyl)-5-[5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-1,2,3,3a,4,6a-hexahydro-pentalen-2-yl ester 
• 210296-12-1 Acetic acid (2R,3R,3aS,6aS)-3-((E)-(S)-1-acetoxy-oct-2-enyl)-5-[5-(tert-butyl-diphenyl-silanyloxy)-pentyl]-1,2,3,3a,4,6a-hexahydro-pentalen-2-yl ester 
• 210296-05-2 (3S,3aS,6aS)-5-[5-(tert-Butyl-diphenyl-silanyloxy)-pentyl]-3-((E)-(S)-1-hydroxy-oct-2-enyl)-3,3a,4,6a-tetrahydro-1H-pentalen-2-one 
• 210296-06-3 (3S,3aS,6aS)-5-[5-(tert-Butyl-diphenyl-silanyloxy)-pentyl]-3-((E)-(R)-1-hydroxy-oct-2-enyl)-3,3a,4,6a-tetrahydro-1H-pentalen-2-one 

Relevant articles and documents

Synthesis of functionalized pentalenes via carbonyl-ene reaction and enzymatic kinetic resolution

The synthesis of functionalized pentalene derivatives is described. Bicyclo[3.3.0]octane-3,7-dione 5 (Weiss diketone) was converted in six steps into the silyl-protected 3-methylbicyclo[3.3.0]octenol 6, which was submitted to Lewis acid catalyzed carbonyl

The Silicon-Hydrogen Exchange Reaction: A Catalytic σ-Bond Metathesis Approach to the Enantioselective Synthesis of Enol Silanes

The use of chiral enol silanes in fundamental transformations such as Mukaiyama aldol, Michael, and Mannich reactions as well as Saegusa-Ito dehydrogenations has enabled the chemical synthesis of enantiopure natural products and valuable pharmaceuticals. However, accessing these intermediates in high enantiopurity has generally required the use of either stoichiometric chiral precursors or stoichiometric chiral reagents. We now describe a catalytic approach in which strongly acidic and confined imidodiphosphorimidates (IDPi) catalyze highly enantioselective interconversions of ketones and enol silanes. These "silicon-hydrogen exchange reactions"enable access to enantiopure enol silanes via tautomerizing σ-bond metatheses, either in a deprotosilylative desymmetrization of ketones with allyl silanes as the silicon source or in a protodesilylative kinetic resolution of racemic enol silanes with a carboxylic acid as the silyl acceptor.

THIENOPYRIMIDINE DERIVATIVE AND USE THEREOF IN MEDICINE

The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.

HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF

The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in general formula (I), and to the preparation method therefor and pharmaceutical compositions comprising the derivatives, and to the use thereof as a therapeutical agent, especially as a DPP-IV inhibitor. The definition of each substituent in formula (I) is the same as the definition in the description.