1128-44-5

Basic information

• Product Name: 1H-Indole-2,3-dione,4-methyl-
• Synonyms: Indole-2,3-dione,4-methyl- (7CI,8CI); Isatin, 4-methyl- (6CI); 4-Methylindole-2,3-dione;4-Methylindoline-2,3-dione; 4-Methylisatin
• CAS NO: 1128-44-5
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.159
• Mol File: 1128-44-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 189 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.301g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.77±0.20(Predicted)
• CAS DataBase Reference: 1H-Indole-2,3-dione,4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2,3-dione,4-methyl-(1128-44-5)
• EPA Substance Registry System: 1H-Indole-2,3-dione,4-methyl-(1128-44-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1128-44-5(Hazardous Substances Data)

Usage

General Description

1H-Indole-2,3-dione,4-methyl-, also known as 4-methylisatin, is a chemical compound with the molecular formula C9H7NO2. It constitutes of an indole group, which is a heterocyclic aromatic organic compound, combined with a 2,3-dione group and a methyl group attached at the 4th position. It is generally used in the field of organic synthesis and pharmaceutical chemistry. However, the specifics about its properties such as boiling point, melting point, density, refractive index, flash point, and even its potential applications or risks to health or environment are not well-documented and may vary based on its form and usage.

InChI:InChI=1/C9H7NO2/c1-5-2-3-6-7(4-5)10-9(12)8(6)11/h2-4H,1H3,(H,10,11,12)

Upstream product

• 15219-34-8 Oxalyl bromide 
• 1189052-03-6 6-methyl-2-nitro-1-[2-iodoethynyl]benzene 
• 131543-46-9 Glyoxal 
• 108-44-1 1-amino-3-methylbenzene 
• 16096-32-5 4-methyl-1H-indole 
• 1388057-45-1 C₉H₇Br₂NO 
• 1132-29-2 2-hydroxyimino-N-m-tolylacetamide 
• 401585-34-0 oxalic acid-bis(3-tolylimidoyl)chloride 

Downstream Products

• 4389-50-8 2-amino-6-methylbenzoic acid 
• 1426932-16-2 C₁₆H₁₃NO₂ 
• 73271-41-7 N-methyl-3-(4-methylphenyl) isatin imine 
• 1608112-09-9 (Z)-4-methyl-3-(2-oxo-2-phenylethylidene)indolin-2-one 
• 20877-81-0 5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 

Relevant articles and documents

Counter-current chromatography separation of isatin derivatives using the sandmeyer methodology

A rapid and efficient method, using high-speed counter-current chromatography (HSCCC) technique, was developed for the separation of isomeric isatin derivatives, prepared following the Sandmeyer route. The biphasic solvent system composed of hexane:ethyl acetate:ethanol:water 1:0.5:0.5:1 (v/v/v/v) was used for all separations.

Excitation-wavelength-dependent photoluminescence of silicon nanoparticles enabled by adjustment of surface ligands

We herein present pioneering studies to reveal that excitation-wavelength-dependent photoluminescence properties of fluorescent silicon nanoparticles (SiNPs) can be realized by rationally designing surface ligands, i.e., several kinds of oxidized indole d

Method for preparing indole-2,3-dione derivatives by catalytic oxidation of microwave copper/peroxyacetic acid

The invention discloses a method for preparing indole-2,3-dione derivatives by catalytic oxidation of microwave copper/peroxyacetic acid. The method comprises the following steps: a catalytic amount of catalyst copper iodide, indole, a derivative of the indole and peroxyacetic acid are added into a reaction vessel, wherein the indole, the derivative of the indole and the peroxyacetic acid are usedas raw materials, ethanol is used as a solvent, the reaction vessel is placed into a microwave reaction instrument, a reaction is performed at certain temperature and power, after a certain time, reduced-pressure concentration is performed, and a product is purified by column chromatography. The method provided by the invention is a method having novel raw materials, simple operation and high efficiency used for preparing a benzimidazole derivative; and compared with the prior art, the method provided by the invention has an obviously-accelerated reaction speed than that under conventional heating, mild reaction conditions, simple operation, a high yield, safety, low costs and environmental protection.

Ylide mediated carbonyl homologations for the preparation of isatin derivatives

An exceptionally mild method for the preparation of isatin derivatives has been developed using a sulfur ylide mediated carbonyl homologation sequence starting from anthranilic acid precursors. This method proceeds at ambient temperature via a sulfur ylide intermediate without the need for protection of the amine or chromatographic isolation of the intermediate ylide. Gentle oxidation of the sulfur ylides provides isatin derivatives with N-H, N-alkyl, N-aryl substitution, electron-rich and electron-poor aromatic rings, and heterocyclic aromatic systems. We anticipate that this method will greatly expand the accessibility of complex isatin derivatives.