1128-47-8

Basic information

• Product Name: 6-Methyl-1H-indole-2,3-dione
• Synonyms: 6-Methylindoline-2,3-dione
• CAS NO: 1128-47-8
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Mol File: 1128-47-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: >147 °C
• Appearance: /
• Density: 1.301g/cm³
• Refractive Index: 1.598
• Storage Temp.: 2-8°C
• PKA: 9.87±0.20(Predicted)
• CAS DataBase Reference: 6-Methyl-1H-indole-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-1H-indole-2,3-dione(1128-47-8)
• EPA Substance Registry System: 6-Methyl-1H-indole-2,3-dione(1128-47-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1128-47-8(Hazardous Substances Data)

Usage

General Description

6-Methyl-1H-indole-2,3-dione, also known as isatin, is a chemical compound with a molecular formula of C8H7NO2. It is a yellow crystalline solid with a characteristic odor, and it is mainly used in the production of various dyes and pigments. Isatin is also known to possess anti-inflammatory, antibacterial, and antiviral properties, making it a versatile compound in the field of medicine and pharmaceuticals. Additionally, it has been studied for its potential use in the treatment of various neurological disorders, cancer, and other diseases. Isatin can be synthesized from the oxidation of indigo or by reacting 2-aminobenzoylformic acid with phosphorus oxychloride.

InChI:InChI=1/C9H7NO2/c1-5-2-3-6-7(4-5)10-9(12)8(6)11/h2-4H,1H3,(H,10,11,12)

Upstream product

• 7664-93-9 sulfuric acid 
• 1132-29-2 2-hydroxyimino-N-m-tolylacetamide 
• 7732-18-5 water 
• 401585-34-0 oxalic acid-bis(3-tolylimidoyl)chloride 
• 3551-75-5 N,N'-bis(3-methylphenyl)oxalamide 
• 131543-46-9 Glyoxal 
• 108-44-1 1-amino-3-methylbenzene 
• 86911-82-2 2,3-dihydro-6-methyl-1H-indole 
• 13194-69-9 2-iodo-5-methylaniline 
• 3420-02-8 6-methylindole 
• 1165892-86-3 C₁₂H₁₃NO₃ 
• 1189052-02-5 4-methyl-2-nitro-1-[2-iodoethynyl]benzene 
• 302-17-0 chloral hydrate 
• 15219-34-8 Oxalyl bromide 

Downstream Products

• 64818-80-0 2-amino-4-methylbenzoic acid ethyl ester 
• 1391858-22-2 (2'S,3'R,4'S)-5',5'-diethyl 3',4'-dimethyl 1-benzyl-6-methyl-2-oxospiro[indoline-3,2'-pyrrolidine]-3',4',5',5'-tetracarboxylate 
• 1391858-02-8 1-benzyl-6-methylindoline-2,3-dione 
• 1469872-12-5 2-(6-methyl-2,3-dioxoindolin-1-yl)-N-phenylacetamide 
• 816448-99-4 7-methylquinoline-4-carboxylic acid 
• 1334175-95-9 3'-amino-5-methyl-2,5',10'-trioxo-5',10'-dihydrospiro [indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2'-carbonitrile 
• 1315268-70-2 5'-methyl-1,3-diphenyl-1H-spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2',5(10H)-dione 
• 1361403-84-0 ethyl 3-acetyl-9-benzyl-4-cyano-7-methyl-4,9-dihydropyrano[2,3-b]indole-4-carboxylate 
• 1361403-72-6 ethyl (E)-2-(1-benzyl-6-methyl-2-oxoindolin-3-ylidene)-2-cyanoacetate 
• 130266-45-4 phenyl 6-methyl isatin 

Relevant articles and documents

Visible-Light-Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides

Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. It should be noted that isatin derivatives are highly important for the synthesis of pharmaceuticals and bioactive compounds. Notably, this chemistry works excellently with N-protected and protection-free indoles. Additionally, this methodology can also be applied to dearomatise pyrrole derivatives to generate cyclic imides in a single step. Later this methodology was applied for the synthesis of four pharmaceuticals and a pesticide called dianthalexin B. Detailed mechanistic studies revealed the actual role of oxygen and photocatalyst.

Double Carbonylation Using Glyoxal (HCOCOH): A Practical Copper-Promoted Synthesis of Isatins from Primary and Secondary Anilines

A novel double carbonylation process has been demonstrated with easily available HCOCOH (glyoxal) as the double carbonylation reagent. Simple CuCl2?2H2O (copper(II) chloride dihydrate) was used as the oxidant for this transformation. Under optimized reaction conditions, various primary and secondary anilines were double-carbonylated to afford their corresponding isatins (26 examples, up to 80% yields). (Figure presented.).

A Palladium-Catalyzed Double Carbonylation Approach to Isatins from 2-Iodoanilines

A high-yielding procedure for the synthesis of isatins has been developed. Sequential Pd-catalyzed double carbonylation of 2-iodoanilines with near stoichiometric amounts of CO followed by acid-promoted cyclization readily affords an array of isatins. The conversion of 2-iodoanilines to isatins in good to excellent yields was found to proceed with good functional group tolerance. This protocol proved adaptable to 13C-isotope labeling of isatins, which was extended to the synthesis of the 13C-isotope labeled antiviral drug metisazone and the experimental anti-schizophrenia drug ML137.