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Cas Database

1131-94-8

1131-94-8

Identification

  • Product Name:Benzeneacetic acid,3-hydroxy-4-methoxy-

  • CAS Number: 1131-94-8

  • EINECS:670-463-7

  • Molecular Weight:182.176

  • Molecular Formula: C9H10O4

  • HS Code:29189900

  • Mol File:1131-94-8.mol

Synonyms:Aceticacid, (3-hydroxy-4-methoxyphenyl)- (7CI,8CI);4-Methoxy-3-hydroxyphenylacetic acid;Homoisovanillic acid;Isohomovanillic acid;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn, IrritantXi

  • Hazard Codes:Xi,Xn

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:3-Hydroxy-4-methoxyphenylacetic Acid
  • Packaging:1g
  • Price:$ 319
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:3-Hydroxy-4-methoxyphenylacetic acid
  • Packaging:10g
  • Price:$ 225
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:3-Hydroxy-4-methoxyphenylacetic Acid >98.0%(GC)(T)
  • Packaging:5g
  • Price:$ 194
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:3-Hydroxy-4-methoxyphenylacetic Acid >98.0%(GC)(T)
  • Packaging:1g
  • Price:$ 47
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Hydroxy-4-methoxyphenylacetic acid 98%
  • Packaging:25 g
  • Price:$ 876
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Hydroxy-4-methoxyphenylacetic acid 98%
  • Packaging:5 g
  • Price:$ 255
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Hydroxy-4-methoxyphenylacetic acid 98%
  • Packaging:1 g
  • Price:$ 75
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:3-Hydroxy-4-methoxyphenylacetic acid 97%
  • Packaging:1g
  • Price:$ 50.9
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:3-Hydroxy-4-methoxyphenylacetic acid
  • Packaging:1 g
  • Price:$ 610
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Hydroxy-4-methoxyphenylacetic acid 98%
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Relevant articles and documentsAll total 17 Articles be found

One-Pot Biocatalytic In Vivo Methylation-Hydroamination of Bioderived Lignin Monomers to Generate a Key Precursor to L-DOPA

Birmingham, William R.,Galman, James L.,Parmeggiani, Fabio,Seibt, Lisa,Turner, Nicholas J.

, (2022/01/13)

Electron-rich phenolic substrates can be derived from the depolymerisation of lignin feedstocks. Direct biotransformations of the hydroxycinnamic acid monomers obtained can be exploited to produce high-value chemicals, such as α-amino acids, however the reaction is often hampered by the chemical autooxidation in alkaline or harsh reaction media. Regioselective O-methyltransferases (OMTs) are ubiquitous enzymes in natural secondary metabolic pathways utilising an expensive co-substrate S-adenosyl-l-methionine (SAM) as the methylating reagent altering the physicochemical properties of the hydroxycinnamic acids. In this study, we engineered an OMT to accept a variety of electron-rich phenolic substrates, modified a commercial E. coli strain BL21 (DE3) to regenerate SAM in vivo, and combined it with an engineered ammonia lyase to partake in a one-pot, two whole cell enzyme cascade to produce the l-DOPA precursor l-veratrylglycine from lignin-derived ferulic acid.

Simple inorganic base promoted C-N and C-C formation: synthesis of benzo[4,5]imidazo[1,2-a]pyridines as functional AIEgens used for detecting picric acid

Yang, Kai,Luo, Shi-He,Chen, Si-Hong,Cao, Xi-Ying,Zhou, Yong-Jun,Lin, Yan-Lan,Huo, Yan-Ping,Wang, Zhao-Yang

supporting information, p. 8133 - 8139 (2021/10/04)

Metal-free catalyzed intermolecular tandem Michael addition/cyclization has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]pyridines from α-bromocinnamaldehyde and 2-substituted benzimidazoles. The reaction promoted by a simple inorganic base displays moderate to good yields and good functional group tolerance. The optical properties of some typical products have been investigated. We found that, due to the presence of the benzene ring at the C1-position of benzo[4,5]imidazo[1,2-a]pyridines which restricts intramolecular motion, as a new type of aggregation-induced emission (AIE) luminogen (AIEgen), they show very good solid-state fluorescence with quantum yields up to 88.80%. Importantly, the AIE performance of compound3bcan be useful to detect the nitroaromatic explosive picric acid (PA) with a detection limit and quenching constant of 42.5 nM and 7.27 × 104M?M, respectively.

COMPOUND AND AN ORGANIC SEMICONDUCTING LAYER, AN ORGANIC ELECTRONIC DEVICE AND A DISPLAY OR LIGHTING DEVICE COMPRISING THE SAME

-

Page/Page column 41; 42, (2020/08/28)

The present invention relates to a compound having the formula (I); and an organic semiconducting layer, an organic electronic device, a display device and a lighting device comprising the same.

Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors

Lee, David Y.W.,Liu, Jing,Zhang, Shuzhen,Huang, Peng,Liu-Chen, Lee-Yuan

supporting information, p. 1437 - 1440 (2017/03/08)

Cocaine addiction remains a serious challenge for clinical and medical research because there is no effective pharmacological treatment. L-THP, a natural product isolated from Corydalis yanhusuo W.T. Wang, is one of the most frequently used traditional herbs to treat drug addiction in China. Our laboratory first reported that its demethylated metabolites L-ICP, L-CD, and L-CP had high affinity at dopamine D1, D2, and D5 receptors. Here we report the chemical synthesis of these metabolites and other derivatives and their binding affinities at dopamine receptors. The synthesis of these bioactive metabolites will allow further in vivo study of their potential in treating cocaine addiction.

Tetrahydropalmatine derivative and application thereof

-

Paragraph 0461; 0465; 0466, (2016/10/08)

The invention relates to a tetrahydropalmatine derivative and application thereof, a compound as shown in a formula (VI) and a preparation method thereof, and an application of the compound in medicine. Specifically, the invention relates to a derivative of the compound as shown in the general formula (VI) and a preparation method thereof, and an application of the derivative as a therapeutic agent in prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, diabetes type II, hyperglycemia, adiposis, or insulin resistance and metabolic syndrome. The compound disclosed by the invention also can reduce total cholesterol, low density lipoprotein (LDL)-cholesterol and triglycerides, and increases the expression of a liver LDL receptor and inhibits the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9).

Process route upstream and downstream products

Process route

(3-bromo-4-methoxy-phenyl)-acetic acid
774-81-2

(3-bromo-4-methoxy-phenyl)-acetic acid

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
With sodium hydroxide; copper(II) sulfate; In water; at 150 ℃; for 36h; sealed bomb;
99%
With bis(8-quinolinolate)copper(II); water; sodium hydroxide; at 110 ℃; for 6h; under 760.051 Torr; Inert atmosphere;
98%
With water; sodium hydroxide;
90%
With sodium hydroxide;
90%
With copper(ll) sulfate pentahydrate; sodium hydroxide; In water; at 150 ℃; for 20h; Sealed tube;
44.4%
With copper(ll) sulfate pentahydrate; sodium hydroxide; In water; at 150 ℃; for 20h; Sealed tube;
44.4%
With copper(ll) sulfate pentahydrate; sodium hydroxide; In water; at 150 ℃; for 20h; Concentration; Sealed tube;
44.4%
methyl 2-(3-bromo-4-methoxyphenyl)acetate
19626-36-9

methyl 2-(3-bromo-4-methoxyphenyl)acetate

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
With water; copper; copper(II) oxide; potassium hydroxide; at 140 ℃; for 1h; Inert atmosphere; Microwave irradiation;
With bis(8-hydroxyquinolato)copper(II); sodium hydroxide; In water; for 6h; under 760.051 Torr; Reflux; Inert atmosphere;
2-bromo-4-methoxy-5-hydroxylphenylacetic acid
81038-48-4

2-bromo-4-methoxy-5-hydroxylphenylacetic acid

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
With formic acid; palladium on activated charcoal; at 100 ℃; for 3h;
76%
2-Chloro-5-hydroxy-4-methoxyphenylacetic acid
81038-49-5

2-Chloro-5-hydroxy-4-methoxyphenylacetic acid

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
With formic acid; palladium on activated charcoal; at 100 ℃; for 6h;
68%
4-Methoxyphenylacetic acid
104-01-8

4-Methoxyphenylacetic acid

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 96 percent / Br2, FeBr2 / CHCl3 / Ambient temperature; 1) 42h, 2) 18h
2: NaOH / CuSO4 / H2O / 216 h / 110 °C / sealed tube; various temperatures, reaction times
With sodium hydroxide; bromine; iron(II) bromide; copper(II) sulfate; In chloroform; water;
Multi-step reaction with 3 steps
1: acetic acid; nitric acid / <0
2: palladium; methanol / Hydrogenation
3: aqueous sulfuric acid; sodium nitrite / Eintragen der Reaktionsloesung in heisse wss. Schwefelsaeure
With methanol; sulfuric acid; nitric acid; palladium; acetic acid; sodium nitrite;
Multi-step reaction with 2 steps
1: bromine; acetic acid / 24 h / 20 °C
2: sodium hydroxide; copper(ll) sulfate pentahydrate / water / 20 h / 150 °C / Sealed tube
With copper(ll) sulfate pentahydrate; bromine; acetic acid; sodium hydroxide; In water;
Multi-step reaction with 2 steps
1: acetic acid / 24 h / 20 °C
2: sodium hydroxide; copper(ll) sulfate pentahydrate / water / 20 h / 150 °C / Sealed tube
With copper(ll) sulfate pentahydrate; sodium hydroxide; In water; acetic acid;
O-benzylhomoisovanillic acid
5487-33-2

O-benzylhomoisovanillic acid

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In methanol;
3-benzyloxy-4-methoxy-benzyl alcohol
1860-60-2

3-benzyloxy-4-methoxy-benzyl alcohol

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: SOCl2 / diethyl ether
2: NaI, NaCN / butan-2-one
3: aq. KOH / methanol; dioxane
4: H2 / Pd-C / methanol
With potassium hydroxide; thionyl chloride; sodium cyanide; hydrogen; sodium iodide; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; butanone;
3-benzyloxy-4-methoxy-benzyl chloride
1699-38-3

3-benzyloxy-4-methoxy-benzyl chloride

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: NaI, NaCN / butan-2-one
2: aq. KOH / methanol; dioxane
3: H2 / Pd-C / methanol
With potassium hydroxide; sodium cyanide; hydrogen; sodium iodide; palladium on activated charcoal; In 1,4-dioxane; methanol; butanone;
2-(3-(benzyloxy)-4-methoxyphenyl)acetonitrile
1699-39-4

2-(3-(benzyloxy)-4-methoxyphenyl)acetonitrile

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: aq. KOH / methanol; dioxane
2: H2 / Pd-C / methanol
With potassium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol;
3-benzyloxy-4-methoxybenzaldehyde
6346-05-0

3-benzyloxy-4-methoxybenzaldehyde

homoisovanillic acid
1131-94-8

homoisovanillic acid

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: NaBH4 / methanol
2: SOCl2 / diethyl ether
3: NaI, NaCN / butan-2-one
4: aq. KOH / methanol; dioxane
5: H2 / Pd-C / methanol
With potassium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium cyanide; hydrogen; sodium iodide; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; butanone;

Global suppliers and manufacturers

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  • Shanghai Upbio Tech Co.,Ltd
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  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:87
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  • Win-Win chemical Co.Ltd
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  • Contact Tel:0086-577-64498589
  • Emails:sales@win-winchemical.com
  • Main Products:55
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  • Kono Chem Co.,Ltd
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