113541-07-4Relevant articles and documents
Synthesis of functionalized γ-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems
Zhao, Qian,Han, Bo,Wang, Biao,Leng, Hai-Jun,Peng, Cheng,Huang, Wei
, p. 26972 - 26976 (2015/03/30)
Two consecutive N-heterocyclic carbene (NHC) catalytic systems were combined in a one-pot cascade reaction for the assembly of aromatic aldehydes and 2-haloenals into a structurally complex γ-lactone backbone. To our knowledge, this is the first report of NHC-catalyzed [3 + 2] annulation of α,β-unsaturated acylazoliums with 1,2-bisnucleophiles.
Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists
Plummer, Christopher W.,Finke, Paul E.,Mills, Sander G.,Wang, Junying,Tong, Xinchun,Doss, George A.,Fong, Tung M.,Lao, Julie Z.,Schaeffer, Marie-Therese,Chen, Jing,Shen, Chun-Pyn,Stribling, D. Sloan,Shearman, Lauren P.,Strack, Alison M.,Van Der Ploeg, Lex H.T.
, p. 1441 - 1446 (2007/10/03)
Structure-activity relationship studies directed toward the optimization of 4,5-diarylimidazole-2-carboxamide analogs as human CB1 receptor inverse agonists resulted in the discovery of the two amide derivatives 24a and b (hCB1 IC50 = 6.1 and 4