1145-04-6

Basic information

• Product Name: 4-BIPHENYLGLYOXAL HYDRATE
• Synonyms: 4-BIPHENYLGLYOXAL HYDRATE;1-((1,1’-biphenyl)-4-yl)-2,2-dihydroxyethanone;2,2-dihydroxy-4’-phenyl-acetophenon;2,2-dihydroxy-4’-phenylacetophenone;4-diphenylglyoxalmonohydrate;Biphenyl-4-glyoxal hydrate;Biphenyl-4-glyoxal hydrate 95%;4-BIPHENYLGLYOXAL HYDRATE, 95+%
• CAS NO: 1145-04-6
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.24
• EINECS: 604-604-1
• Product Categories: Biphenyl & Diphenyl ether
• Mol File: 1145-04-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 113-117 °C
• Boiling Point: 393.1 °C at 760 mmHg
• Flash Point: 205.7 °C
• Appearance: /
• Density: 1.256 g/cm³
• Vapor Pressure: 4.48E-05mmHg at 25°C
• PKA: 10.71±0.41(Predicted)
• CAS DataBase Reference: 4-BIPHENYLGLYOXAL HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BIPHENYLGLYOXAL HYDRATE(1145-04-6)
• EPA Substance Registry System: 4-BIPHENYLGLYOXAL HYDRATE(1145-04-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1145-04-6(Hazardous Substances Data)

Usage

General Description

4-Biphenylglyoxal Hydrate is a chemical compound most commonly utilized in chemical research and in the production of other chemicals. It falls under the category of aromatic glyoxals and is also known as 4-phenylbenzaldehyde glyoxal hydrate. Its chemical formula is C14H10O3 and its molecular weight is 226.23 g/mol. It is solid in form and can also be identified by its CAS number 18895-62-2. It's crucial to handle this compound with care given its possible hazards, including skin and eye irritation.

InChI:InChI=1/C14H10O2.H2O/c15-10-14(16)13-8-6-12(7-9-13)11-4-2-1-3-5-11;/h1-10H;1H2

Upstream product

• 99114-42-8 α-methanesulfonyloxy-p-phenylacetophenone 
• 46817-48-5 1-Biphenyl-4-yl-2-methylsulfanyl-ethanone 
• 135-73-9 2-Bromo-4'-phenylacetophenone 
• 5697-41-6 (2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)dimethylsulfonium bromide 
• 28179-30-8 1‐([1,1'‐biphenyl]‐4‐yl)‐2,2‐dibromoethan‐1‐one 
• 37166-61-3 1-([1,1′-biphenyl]-4-yl)-2-hydroxyethanone 
• 92-91-1 biphenyl-4-acetaldehyde 

Downstream Products

• 101201-12-1 4-(α-Ethoxy-4-phenyl-phenacylamino)-benzoesaeure-ethylester 
• 1370418-43-1 (E)-1-([1,1'-biphenyl]-4-yl)-2-((4-methoxyphenyl)imino)ethanone 
• 89015-27-0 (R)-α-hydroxyphenylacetic acid iso-propyl ester 

Relevant articles and documents

An efficient synthesis of imidazo[2,1-b][1,3,4]thiadiazol-7-ium hydroxides by a one-pot, three-component reaction in water

An improved synthesis of 2-ethyl-5-(2-hydroxy-4-oxoquinolin-3(4H)-ylidene)-6-aryl-5,6-dihydroimidazo[2,1-b][1,3,4]thiadiazol-7-ium hydroxide derivatives 4a-k via the reaction of aryl glyoxal monohydrates 1a-k, quinoline-2,4-diol 2 and 2-amino-[1,3,4]thiadiazole (3) in the presence of Et3N/sulfamic acid in H2O is described. This green protocol is characterized by the use of the readily available catalyst and reactants, short reaction times, operational simplicity and high yields of products. The structures of all compounds were characterized by 1H NMR, 13C NMR and Fourier-transform infrared (FT-IR) spectral data and microanalyses.

Naphthol synthesis: Annulation of nitrones with alkynes: Via rhodium(III)-catalyzed C-H activation

An efficient and redox-neutral naphthol synthesis has been realized via rhodium(iii) catalyzed C-H activation of α-carbonyl nitrones and annulation with alkynes, where the nitrone group functioned as a traceless directing group.

Synthesis of α-ketothioamides via willgerodt-kindler reaction of arylglyoxals with amines and sulfur under solvent-free conditions

Willgerodt-Kindler reaction of arylglyoxal hydrates with secondary amines and elemental sulfur under solvent-free conditions at 80 °C is developed, in which α-ketothioamides are obtained in 70-90% yield in 0.6-1 hour. The X-ray crystal-structure analysis for one compound was obtained. Georg Thieme Verlag Stuttgart . New York.