1146014-25-6

Basic information

• Product Name: (2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylbenzoate
• Synonyms: (2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylbenzoate
• CAS NO: 1146014-25-6
• Molecular Weight: 268.312
• Mol File: 1146014-25-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylbenzoate(1146014-25-6)
• EPA Substance Registry System: (2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-ylbenzoate(1146014-25-6)

Safety Data

• Hazardous Substances Data: 1146014-25-6(Hazardous Substances Data)

Upstream product

• 612-17-9 1,4-dihydronaphthalene 
• 2461-35-0 2,3-epoxy-1,2,3,4-tetrahydronaphthalene 
• 65-85-0 benzoic acid 

Downstream Products

• 1146014-79-0 (2R,3R)-3-(2-methallyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl benzoate 

Relevant articles and documents

Organocatalytic asymmetric hydrolysis of epoxides

The hydrolytic ring opening of epoxides is an important biosynthetic transformation and is also applied industrially. We report the first organocatalytic variant of this reaction, exploiting our recently discovered activation of carboxylic acids with chiral phosphoric acids via heterodimerization. The methodology mimics the enzymatic mechanism, which involves an enzyme-bound carboxylate nucleophile. A newly designed phosphoric acid catalyst displays high stereocontrol in the desymmetrization of meso-epoxides. The methodology shows wide generality with cyclic, acylic, aromatic, and aliphatic substrates. We also apply our method in the first highly enantioselective anti-dihydroxylation of simple olefins.