114872-54-7

Basic information

• Product Name: Propanedioic acid, (acetylamino)[(3-chlorophenyl)methyl]-, diethyl ester
• CAS NO: 114872-54-7
• Molecular Formula: C16H20ClNO5
• Molecular Weight: 341.791
• Mol File: 114872-54-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (acetylamino)[(3-chlorophenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (acetylamino)[(3-chlorophenyl)methyl]-, diethyl ester(114872-54-7)
• EPA Substance Registry System: Propanedioic acid, (acetylamino)[(3-chlorophenyl)methyl]-, diethyl ester(114872-54-7)

Safety Data

• Hazardous Substances Data: 114872-54-7(Hazardous Substances Data)

Upstream product

• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 105-53-3 diethyl malonate 
• 13433-00-6 diethyl aminomalonate hydrochloride 
• 766-80-3 1-bromomethyl-3-chlorobenzene 

Downstream Products

• 120108-62-5 2-amino-3-(3-chlorophenyl)propionic acid hydrochloride 
• 856571-14-7 2-(2-aminobenzoylamino)-3-(3-chlorophenyl)propionic acid ethyl ester 
• 457654-55-6 2-amino-3-(3-chlorophenyl)propionic acid ethyl ester hydrochloride 
• 856571-33-0 3-(3-chlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester 
• 1956-15-6 3-chlorophenylalanine 

Relevant articles and documents

Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines

With a dual organocatalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer and under the irradiation with visible light, an enantioselective Minisci-type addition of α-amino acid-derived redox-active esters (RAEs) to isoquinolines has been developed. A variety of prochiral α-aminoalkyl radicals generated from RAEs were successfully introduced on isoquinolines, providing a range of valuable α-isoquinoline-substituted chiral secondary amines in high yields with good to excellent enantioselectivities.

Ion channel modulating agents

The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SK Ca, IK Ca and BK Ca channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, for methods of therapy, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.