1154243-75-0

Basic information

• Product Name: [4-(4-bromophenoxy)(2-pyridyl)]-N-methylcarboxamide
• Synonyms: [4-(4-bromophenoxy)(2-pyridyl)]-N-methylcarboxamide
• CAS NO: 1154243-75-0
• Molecular Weight: 307.147
• Mol File: 1154243-75-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [4-(4-bromophenoxy)(2-pyridyl)]-N-methylcarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(4-bromophenoxy)(2-pyridyl)]-N-methylcarboxamide(1154243-75-0)
• EPA Substance Registry System: [4-(4-bromophenoxy)(2-pyridyl)]-N-methylcarboxamide(1154243-75-0)

Safety Data

• Hazardous Substances Data: 1154243-75-0(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 220000-87-3 4-chloro-N-methylpicolinamide 

Downstream Products

• 284461-73-0 sorafenib 

Relevant articles and documents

Preparation method of sorafenib compound

The invention discloses a preparation method of a sorafenib compound. The preparation method comprises the following steps of: adopting reaction of 2-chloro-5-aminotrifluorotoluene and sodium cyanateto prepare a compound III, reaction of 4-bromophenol (compound IV) and a compound V to prepare a compound VI, and reaction of the compound VI and the compound III to obtain a final product, i.e., sorafenib (I). The preparation method disclosed by the invention has the beneficial effects that raw materials for reaction are low in cost and easy in obtaining, the process route is simple, the total yield is high, the side products are fewer, so that the preparation method is suitable for industrial production.