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115509-32-5

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115509-32-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 115509-32-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,5,0 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 115509-32:
(8*1)+(7*1)+(6*5)+(5*5)+(4*0)+(3*9)+(2*3)+(1*2)=105
105 % 10 = 5
So 115509-32-5 is a valid CAS Registry Number.

115509-32-5Downstream Products

115509-32-5Relevant articles and documents

Design, Synthesis, and Anti-RNA Virus Activity of 6′-Fluorinated-Aristeromycin Analogues

Yoon, Ji-Seong,Kim, Gyudong,Jarhad, Dnyandev B.,Kim, Hong-Rae,Shin, Young-Sup,Qu, Shuhao,Sahu, Pramod K.,Kim, Hea Ok,Lee, Hyuk Woo,Wang, Su Bin,Kong, Yun Jeong,Chang, Tong-Shin,Ogando, Natacha S.,Kovacikova, Kristina,Snijder, Eric J.,Posthuma, Clara C.,Van Hemert, Martijn J.,Jeong, Lak Shin

, p. 6346 - 6362 (2019)

The 6′-fluorinated aristeromycins were designed as dual-target antiviral compounds aimed at inhibiting both the viral RNA-dependent RNA polymerase (RdRp) and the host cell S-adenosyl-l-homocysteine (SAH) hydrolase, which would indirectly target capping of viral RNA. The introduction of a fluorine at the 6′-position enhanced the inhibition of SAH hydrolase and the activity against RNA viruses. The adenosine and N6-methyladenosine analogues 2a-e showed potent inhibition against SAH hydrolase, while only the adenosine derivatives 2a-c exhibited potent antiviral activity against all tested RNA viruses such as Middle East respiratory syndrome-coronavirus (MERS-CoV), severe acute respiratory syndrome-coronavirus, chikungunya virus, and/or Zika virus. 6′,6′-Difluoroaristeromycin (2c) showed the strongest antiviral effect for MERS-CoV, with a ~2.5 log reduction in infectious progeny titer in viral load reduction assay. The phosphoramidate prodrug 3a also demonstrated potent broad-spectrum antiviral activity, possibly by inhibiting the viral RdRp. This study shows that 6′-fluorinated aristeromycins can serve as starting points for the development of broad-spectrum antiviral agents that target RNA viruses.

Chiral syntheses of 6′-β-fluoroaristeromycin, 6′-β-fluoro-5′-noraristeromycin and aristeromycin

Yin, Xue-Qiang,Schneller, Stewart W.

, p. 7535 - 7538 (2007/10/03)

Carbocyclic nucleosides substituted at the C-6′ position are receiving increasing attention. Chiral synthetic accessibility to the biologically promising 6′-β-fluoroaristeromycin is lacking. Its preparation and that of the 5′-nor analogue are described. A

Purinyl or pyrimidinyl substituted hydroxycyclopentane compounds useful as antivirals

-

, (2008/06/13)

Novel 4-substituted-5-hydroxymethyl-1,2-cyclopentanediols or 1-cyclopentanol substituted at the 3-position by various heterocyclic groups are useful as antiviral agents.

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