1156491-10-9

Basic information

• Product Name: (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
• Synonyms: (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-aMine HCL;(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;CYCLOPROPANAMINE, 2-(3,4-DIFLUOROPHENYL)-, HYDROCHLORIDE (1:1), (1R,2S)-REL-
• CAS NO: 1156491-10-9
• Molecular Formula: C9H10ClF2N
• Molecular Weight: 205.6322064
• EINECS: 1308068-626-2
• Product Categories: Intermediate of Ticagrelor
• Mol File: 1156491-10-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine(1156491-10-9)
• EPA Substance Registry System: (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine(1156491-10-9)

Safety Data

• Hazardous Substances Data: 1156491-10-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine is used as an intermediate in the synthesis of ticagrelor (T437700), a medication used to prevent blood clots in patients with acute coronary syndrome or a history of heart attack.
The compound's specific configuration and reactivity make it a valuable building block in the development of pharmaceuticals, particularly those targeting cardiovascular conditions. Its use in the synthesis of ticagrelor highlights its importance in the creation of life-saving medications.

InChI:InChI=1S/C9H9F2N.ClH/c10-7-2-1-5(3-8(7)11)6-4-9(6)12;/h1-3,6,9H,4,12H2;1H/t6?,9-;/m1./s1

Upstream product

• 451455-95-1 diethyl (3,4-difluoro-benzyl)phosphonate 
• 51336-95-9 2-chloro-1-(3,4-difluorophenyl)ethan-1-one 
• 367-11-3 ortho-difluorobenzene 

Downstream Products

• 274693-27-5 ticagrelor 
• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 

Relevant articles and documents

Preparation method of chiral aromatic cyclopropylamine and salt thereof and intermediate used in preparation method

The embodiment of the invention provides a preparation method of a compound as shown in a formula I or salt thereof, which comprises the following steps: (1) reacting a compound as shown in a formulaVI with a compound as shown in a formula VII in a first

Preparation method of ticagrelor

The invention discloses a preparation method of ticagrelor. The preparation method comprises the following steps: (1) preparation of ticagrelor intermediate product 1-TK acid; (2) preparation of ticagrelor intermediate product 2-TK-amide; (3) preparation of ticagrelor intermediate product 3-TK-amino compound hydrochloride; (4) preparation of ticagrelor intermediate product 4-TK-amino compound R-tartrate; ( 5) preparation of ticagrelor intermediate product 5-TK-amino compound L-mandelate; and (6) preparation of ticagrelor-TK. The preparation method has the advantages of cost advantage, mature and stable process, stable product quality, and safe and reliable production process.