116-41-6

Basic information

• Product Name: N-(2-methoxy-5-methylphenyl)-4-methylbenzenesulfonamide
• CAS NO: 116-41-6
• Molecular Weight: 291.371
• Mol File: 116-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-methoxy-5-methylphenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methoxy-5-methylphenyl)-4-methylbenzenesulfonamide(116-41-6)
• EPA Substance Registry System: N-(2-methoxy-5-methylphenyl)-4-methylbenzenesulfonamide(116-41-6)

Safety Data

• Hazardous Substances Data: 116-41-6(Hazardous Substances Data)

Upstream product

• 104-93-8 p-methylanizole 
• 50597-88-1 2-iodo-4-methylanisole 
• 70-55-3 toluene-4-sulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 120-71-8 Cresidine 

Downstream Products

• 170275-09-9 toluene-4-sulfonic acid-(2-methoxy-5-methyl-4-nitro-anilide) 

Relevant articles and documents

One-pot ortho-amination of aryl C-H bonds using consecutive iron and copper catalysis

A one-pot approach for ortho-coupling of arenes with non-actived N-nucleophiles has been developed using sequential iron and copper catalysis. Regioselective ortho-activation of anisoles, anilines and phenols was achieved through iron(iii) triflimide catalysed iodination, followed by a copper(i)-catalysed, ligand-assisted coupling reaction with N-heterocycle, amide and sulfonamide-based nucleophiles. The synthetic utility of this one-pot, two-step method for the direct amination of ortho-aryl C-H bonds was demonstrated with the late-stage functionalisation of 3,4-dihydroquinolin-2-ones. This allowed the preparation of a TRIM24 bromodomain inhibitor and a series of novel analogues.