1161012-23-2Relevant articles and documents
A class of α-amino acids-derived multifunctional amidophosphane precatalysts: application to the highly enantio- and diastereoselective silver(I)-catalyzed 1,3-dipolar cycloaddition reaction
Hou, Yihui,Zhou, Zhipeng,Liu, Pingle,Wang, Jiankang,Hou, Qinglin,Wen, Pushan,Wang, Haifei
, p. 930 - 938 (2017/07/11)
A class of multifunctional amidophosphanes derived from chiral α-amino acids have been developed with two amide bonds, a tertiary amine and a phosphine. In combination with Ag(I) salts, these amidophosphanes have been demonstrated as highly efficient multifunctional catalysts in the asymmetric 1,3-dipolar cycloaddition of azomethine ylides as well as the three-component reaction of the α-iminoesters in situ generated. Under optimal conditions, highly functionalized endo-8 pyrrolidines were obtained with good to excellent yields (up to 99% yield) and enantioselectivities (up to 98% ee).
CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS
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Page/Page column 63-64, (2009/12/28)
Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS
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Page/Page column 68-71, (2008/06/13)
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