116171-03-0

Basic information

• Product Name: 4-AMINO-5-BENZOYL-2-(METHYLSULFANYL)-3-THIOPHENECARBONITRILE
• Synonyms: 4-AMINO-5-BENZOYL-2-(METHYLSULFANYL)-3-THIOPHENECARBONITRILE;4-AMINO-5-BENZOYL-2-(METHYLSULFANYL)THIOPHENE-3-CARBONITRILE
• CAS NO: 116171-03-0
• Molecular Formula: C₁₃H₁₀N₂OS₂
• Molecular Weight: 274.36
• Mol File: 116171-03-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-AMINO-5-BENZOYL-2-(METHYLSULFANYL)-3-THIOPHENECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-5-BENZOYL-2-(METHYLSULFANYL)-3-THIOPHENECARBONITRILE(116171-03-0)
• EPA Substance Registry System: 4-AMINO-5-BENZOYL-2-(METHYLSULFANYL)-3-THIOPHENECARBONITRILE(116171-03-0)

Safety Data

• Hazardous Substances Data: 116171-03-0(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 20602-68-0 potassium (2,2-dicyano-1-methylsulfanylethen-1-yl)thiolate 
• 131847-35-3 4-Amino-5-benzoyl-2-mercapto-thiophene-3-carbonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 139299-17-5 4-Amino-5-benzoyl-2-hydrazino-thiophene-3-carbonitrile 
• 230310-97-1 4-amino-5-benzoyl-2-m-tolyloxy-thiophene-3-carbonitrile 
• 230310-96-0 4-amino-5-benzoyl-2-phenoxy-thiophene-3-carbonitrile 
• 39689-69-5 4-amino-5-benzoyl-2-(piperidin-1-yl)thiophene-3-carbonitrile 
• 139299-13-1 4-amino-5-benzoyl-2-methylsulfonyl-3-thiophene-carbonitril 

Relevant articles and documents

Highly mild approach towards synthesis of tetrasubstituted thiophenes by an organic salt afforded by cyclic thioureas and ketene dithioacetals

An organic salt generated by cyclic thioureas and 2-di(methylsulfanyl)methylene malononitrile in reaction with primary and secondary α-haloketones leads to tetrasubstituted thiophenes without using additional base or catalyst at room temperature. The S-methylisothiourea moiety of this salt as an organocatalyst performs a hybrid function of thiourea and imidazole to activate electrophiles via H-bonding and trigger cyclization via Lewis basicity character, respectively. Interestingly, a green solvent (in two step mode), short reaction time, easy purification, high yield and selectivity accompany this protocol. The structures of the intermediate and afforded adducts are fully characterized by analytical investigations and X-ray crystallography.

Heterocondensed thiophenes and thiazoles by Thorpe-Ziegler cyclization

(Chemical Equation Presented) The syntheses of novel thieno-pyridones, thiazolo-pyridones, thiazolo-pyridines and amino- and diamino-dieno-pyridines were described. Simultaneously, it was demonstrated that in these compounds and in the related 3-aminothio

A convenient synthesis of 2,3,4,5-functionalised thieno[2,3-b]thiophenes

A two steps simple synthesis of 2,3,4,5-functionalised thieno[2,3-b]thiophenes 2-6 from ketene dimethylthioacetals is described.

New syntheses of 2,4-diaminothiophenes - Use of (1,3-oxathiol-2-ylidene)malononitrile

Preparation of 2,4-diaminothiophenes using (1,3-oxathiol-2-ylidene)-malononitrile as intermediate was achieved.

Thieno[2',3':3,4]pyrazolo[1,5-a]pyrimidines and -triazines: Synthesis of the novel ring-systems

The novel tricyclic ring systems 14 can be prepared by reaction of thienopyrazoles 5 with 1,3-dielectrophiles, such as acetylacetone, dibenzoylmethane or 1,2,4-dithiazole 8. An other synthetic route for the preparation of the tricyclic systems, based on the pyrazoloazines 13, was investigated. The compounds 5 and 14 were tested for antiulcer activity.