116241-59-9

Basic information

• Product Name: Ethyl 6-Fluoro-Nicotinate
• Synonyms: Ethyl 6-Fluoro-Nicotinate;3-Pyridinecarboxylic acid, 6-fluoro-, ethyl ester
• CAS NO: 116241-59-9
• Molecular Formula: C₈H₈FNO₂
• Molecular Weight: 169.1530232
• Mol File: 116241-59-9.mol

Chemical Properties

• Boiling Point: 228.5±20.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -2.36±0.10(Predicted)
• CAS DataBase Reference: Ethyl 6-Fluoro-Nicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 6-Fluoro-Nicotinate(116241-59-9)
• EPA Substance Registry System: Ethyl 6-Fluoro-Nicotinate(116241-59-9)

Safety Data

• Hazardous Substances Data: 116241-59-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Ethyl 6-Fluoro-Nicotinate is used as a key intermediate in the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure and properties make it a valuable component in the development of new drugs.
Used in the Treatment of Neurological Disorders:
Ethyl 6-Fluoro-Nicotinate is used as a potential therapeutic agent for the treatment of neurological disorders. Its effects on the nervous system are being studied to understand its potential benefits in managing such conditions.
Used as an Anticonvulsant:
Ethyl 6-Fluoro-Nicotinate is used as an anticonvulsant, being investigated for its potential to help control seizures and other convulsive disorders. Its role in modulating neuronal activity is of interest in the field of epilepsy treatment and management.

Upstream product

• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 18617-50-0 ethyl 6-hydroxypyridine-3-carboxylate 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 116241-52-2 C₈H₉FNO₂⁽¹⁺⁾*BF₄^(1-) 

Relevant articles and documents

Original synthesis of radiolabeling precursors for batch and on resin one-step/late-stage radiofluorination of peptides

Radiolabeling of peptides with fluorine-18 is hurdled by their chemical sensitivity and complicated processes. Original triflyl-pyridine intermediates afforded ammonium precursors that were radiolabeled at low temperature. From that study, a generic tag h

Preparation of 2-Fluoropyridines via Base-Induced Decomposition of N-Fluoropyridinium Salts

N-Fluoropyridinium salts with either BF4-, SbF6-, or PF6- as a counteranion were treated with excess base such as triethylamine at room temperature to give 2-fluoropyridine in good yield.This method was succesfully applied to the preparation of 2-fluoropyridine derivatives possessing electron-donating or -withdrawing substituents using substituted N-fluoropyridinium tetrafluoroborates.Pyridine-F2 compounds produced through reactions of pyridines with molecular fluorine were also treated with base to give 2-fluoropyridines but in low yields.These reactions are considered to occur through a carbene mechanism as follows: a novel N-F-containing cyclic carbene (3), generated from the N-fluoropyridinium salts by 2-proton abstraction, reacts with fluorine atoms from counteranions such as BF4-, SbF6-, or PF6-, followed by elimination of F- from the N-F moiety, to yield 2-fluoropyridines.Previously reported findings in reactions of pyridines with molecular fluorine are explained on the basis of this mechanism.