116278-69-4

Basic information

• Product Name: 6-AMino-2,3-dichlorophenol
• Synonyms: 6-AMino-2,3-dichlorophenol
• CAS NO: 116278-69-4
• Molecular Formula: C₆H₅Cl₂NO
• Molecular Weight: 178.016
• Mol File: 116278-69-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 6-AMino-2,3-dichlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMino-2,3-dichlorophenol(116278-69-4)
• EPA Substance Registry System: 6-AMino-2,3-dichlorophenol(116278-69-4)

Safety Data

• Hazardous Substances Data: 116278-69-4(Hazardous Substances Data)

Usage

Uses

Used in Dye and Pigment Production:
6-Amino-2,3-dichlorophenol is used as a chemical intermediate for the production of dyes and pigments. Its unique chemical structure allows for the creation of a wide range of colors and properties in these products.
Used in Pharmaceutical Synthesis:
6-Amino-2,3-dichlorophenol is used as a building block in the synthesis of various pharmaceuticals. Its reactivity and functional groups make it a valuable component in the development of new drugs and medications.
Used in Organic Compound Synthesis:
6-Amino-2,3-dichlorophenol is used as a starting material or intermediate in the synthesis of other organic compounds. Its versatility in chemical reactions allows for the creation of a variety of different products.
Used in Agricultural Chemical Production:
6-Amino-2,3-dichlorophenol is used as an intermediate in the production of agricultural chemicals. Its properties make it suitable for use in the development of pesticides, herbicides, and other agrochemicals.
Used as a Laboratory Reagent:
6-Amino-2,3-dichlorophenol is used as a laboratory reagent for various chemical analyses and experiments. Its stability and reactivity make it a useful tool in research and development settings.

Upstream product

• 7772-99-8 stannous chloride 
• 28165-60-8 2,3-dichloro-6-nitrophenol 
• 116278-64-9 C₁₁H₁₃Cl₂NO₂ 

Relevant articles and documents

IL-8 RECEPTOR ANTAGONISTS

The present invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease states mediated by the chemokine Interleukin-8 (IL-8).

IL-8 RECEPTOR ANTAGONISTS

Novel IL-8 receptor antagonists and methods of using them are provided.

IL-8 RECEPTOR ANTAGONISTS

This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

IL-8 RECEPTOR ANTAGONISTS

This invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease scates mediated by the chemokine, Interleukin-8 (IL-8). In particular, this invention relates to the novel compounds of Formula (Ia) and their use in treating chemokine mediated diseases wherein the chemokine binds to an IL-8 a or b receptor. Compounds of Formula (Ia) are represented by the structure: STR1 wherein interalia, X is oxygen or sulfur;Rb is NR 6 R. sub.7, alkcyl, aryl, arylC 1-4 alkyl, aryl C 2-4 alkenyl, heteroaryl, heteroarylC 1-4 alkyl, heteroarylC 2-4 alkenyl, heterocyclic or heterocyclic C 1-4 alkyl, or a heterocyclic C 2-4 alkenyl moiety, camphor, all of which may be optionally substituted; R 1 is independently selected from hydrogen; halogen; nitro; cyano; C 1-10 alkyl; halosubstituted C 1-10 alkyl; C 2-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR. sub.8 R 8)q S(O) t R 4 ; hydroxy; hydroxy substituted C 1-4 alkyl; aryl; aryl C 1-4 alkyl; aryl C 2-10 alkenyl; aryloxy; aryl C 1-4 alkyloxy; heteroaryl; heteroarylalkyl; heteroaryl C 2-10 alkenyl; heteroaryl C 1-4 alkyloxy; heterocyclic; heterocyclic C 1-4 alkyl; heterocyclicC 1-4 alkyloxy; heterocyclic C 2-10 alkenyl; q is 0 or an integer having a value of 1 to 10; n is an integer having a value of 1 to 3;m is an integer having a value of 1 to 3; Y is hydrogen; halogen; nitro; cyano; halosubstituted C 1-10 alkyl; C 1-10 alkyl; C 2-10 alkenyl C. sub.1-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR 8 R. sub.8)qS(O) t R 4, (CR 8 R 8)qOR 4 ; hydorxy; hydroxy substituted C. sub.1-4 alkyl; aryl; aryl C 1-4 alkyl; aryloxy; arylC. sub.1-4 alkyloxy; aryl C 2-10 alkenyl; heteroaryl; heteroarylalkyl; heteroaryl C 1-4 alkyloxy; heteroaryl C 2-10 alkenyl; heterocyclic, heterocyclic C 1-4 alkyl; heterocyclicC 2-10 alkenyl;or a pharmaceutically acceptable salt thereof.

Hydrolysis and Fe2+-induced Reduction of N-Aryl -O-pivaloylhydroxylamines: Aqueous Solution Chemistry of Model Carcinogens.

The N-aryl-O-pivaloylhydroxylamines, 1a-d, which serve as models for the carcinogenic metabolites of aromatic amines, decompose in aqueous media by heterolysis of the N-O bond.Substituent effects on rates of reaction and products of the decomposition of 1a-c are entirely consistent with the intermediacy of a singlet nitrenium ion.The least reactive compound in the series N-(4-nitrophenyl)-O-pivaloylhydroxylamine (1d) yields 4-nitroaniline (2d) as its major decomposition product.This material may be formed through H radical abstraction by a triplet ion, but a nitrene reaction appears to be more likely.In the presence of Fe2+ 1a-d undergo rapid reduction to the corresponding anilines 2a-d.This reaction requires complexation of the ester with Fe2+ and proceeds with heterolysis of the N-O bond since nearly quantitative yields of pivalic acid are isolated.The radical cations 25a-d appear to be the most likely precursors to the reduction products.