116762-25-5Relevant articles and documents
The formation of benzoxacin-3-ones: Via intramolecular Nicholas reactions and synthesis of 8-membered heliannuols
Green, James R.,St. Onge, Brent
, p. 7152 - 7155 (2021/08/30)
The γ-carbonyl cations generated from propargyl ether-Co2(CO)6 complexes undergo intramolecular Nicholas reactions to give dehydrobenzoxacin-3-one-Co2(CO)6 complexes in good yields. Reductive decomplexation and subsequent manipulation allows the synthesis of (±)-heliannuol K methyl ether and the formal syntheses of (±)-heliannuol K, (±)-heliannuol A, and (-)-heliannuol L.
Pd(II)-catalyzed ortho - Or meta-C-H olefination of phenol derivatives
Dai, Hui-Xiong,Li, Gang,Zhang, Xing-Guo,Stepan, Antonia F.,Yu, Jin-Quan
, p. 7567 - 7571 (2013/06/27)
A combination of weakly coordinating auxiliaries and ligand acceleration allows for the development of both ortho- and meta-selective C-H olefination of phenol derivatives. These reactions demonstrate the feasibility of directing C-H functionalizations when functional groups are distal to target C-H bonds. The meta-C-H functionalization of electron-rich phenol derivatives is unprecedented and orthogonal to previous electrophilic substitution of phenols in terms of regioselectivity. These methods are also applied to functionalize α-phenoxyacetic acids, a fibrate class of drug scaffolds.
Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites
Shamovsky, Igor,De Graaf, Chris,Alderin, Lisa,Bengtsson, Malena,Bladh, H?kan,B?rjesson, Lena,Connolly, Stephen,Dyke, Hazel J.,Van Den Heuvel, Marco,Johansson, Henrik,Josefsson, Bo-G?ran,Kristoffersson, Anna,Linnanen, Tero,Lisius, Annea,M?nnikk?, Roope,Nordén, Bo,Price, Steve,Ripa, Lena,Rognan, Didier,Rosendahl, Alexander,Skrinjar, Marco,Urbahns, Klaus
supporting information; experimental part, p. 7706 - 7723 (2010/07/04)
The metabolic stability and selectivity of a series of CCR8 antagonists against binding to the hERGion channel and cytochrome Cyp2D6 are studied by principal component analysis. It is demonstrated that an efficient way of increasing metabolic stability an
TANDEM INTRAMOLECULAR WITTIG AND CLAISEN REARRANGEMENT REACTIONS IN THE THERMOLYSIS OF 2-METHYL-2-PHENOXY-PROPIONYL-CYANOMETHYLENETRIPHENYLPHOSPHORANES: SYNTHESIS OF SUBSTITUTED 2H-1-BENZOPYRANS AND BENZOFURANS
Rehman, H.,Rao, Jampani Madhusudana
, p. 5335 - 5340 (2007/10/02)
The preparation and thermolysis in vacuum of 2-methyl-2-phenoxy-propionyl-cyanomethylenetriphenylphosphorane and derivatives containing methyl-, methoxy- and chloro- substituents in the phenoxy ring is reported.The method merges the preparation of phenyl