Welcome to LookChem.com Sign In|Join Free

CAS

  • or

116922-60-2

Post Buying Request

116922-60-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

116922-60-2 Usage

General Description

3-Bromo-4-fluoropyridine is a chemical compound with the molecular formula C5H3BrFN. It is a pale yellow to light brown liquid with a molecular weight of 172.988 g/mol. This chemical is primarily used in pharmaceutical and agrochemical applications as an intermediate for the synthesis of various compounds. It is also used in research and development for the creation of new drugs and materials. 3-Bromo-4-fluoropyridine is known to be a flammable liquid and should be handled with caution in a well-ventilated area and with appropriate safety measures in place.

Check Digit Verification of cas no

The CAS Registry Mumber 116922-60-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,9,2 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 116922-60:
(8*1)+(7*1)+(6*6)+(5*9)+(4*2)+(3*2)+(2*6)+(1*0)=122
122 % 10 = 2
So 116922-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H3BrFN/c6-4-3-8-2-1-5(4)7/h1-3H

116922-60-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Bromo-4-fluoropyridine

1.2 Other means of identification

Product number -
Other names Pyridine,3-bromo-4-fluoro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:116922-60-2 SDS

116922-60-2Upstream product

116922-60-2Relevant articles and documents

Synthesis of: Meta -substituted [18F]3-fluoro-4-aminopyridine via direct radiofluorination of pyridine N -oxides

Brugarolas,Freifelder,Cheng,Dejesus

, p. 7150 - 7152 (2016)

Due to their electron-rich aromatic structure, nucleophilic (radio)fluorination of pyridines is challenging, especially at the meta position. In this paper, we describe the first example of direct fluorination of a pyridine N-oxide to produce a meta fluorinated pyridine. Specifically, fluorination of 3-bromo-4-nitropyridine N-oxide produced in several minutes 3-fluoro-4-nitropyridine N-oxide in moderate yield at room temperature. This intermediate compound was later converted to 3-fluoro-4-aminopyridine easily by catalytic hydrogenation. Furthermore, this approach was successfully applied for labeling with fluorine-18. The use of pyridine N-oxides for the preparation of fluoropyridines is unprecedented in the chemical literature and has the potential to offer a new way for the synthesis of these important structures in pharmaceuticals and radiopharmaceuticals.

Directed Lithiation of 4-Halopyridines: Chemoselectivity, Regioselectivity and Application to Synthesis

Marsais, F.,Trecourt, F.,Breant, P.,Queguiner, G.

, p. 81 - 87 (2007/10/02)

4-Chloro and 4-fluoropyridines were ortho-lithiated by n-butyllithium-TMEDA chelate or lithium diisopropylamide at low temperature.The resulting 3-lithio 4-halopyridines were reacted with electrophiles which led to various 3,4-disubstituted pyridines.The versatility of this functionalization is enhanced by the 4-halogen reactivity towards nucleophiles such as water, methylate and amines.Some of the 3,4-disubstituted synthons were annelated to naphthyridine, xanthone and coumarin or condensed to Hantzsch-ester or to "chlotrimazol" analogues.Lithiation of 4-fluoropyridine led in one step to 3,4-pyridyne, which was trapped by cycloaddition with furans.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 116922-60-2