117423-41-3

Basic information

• Product Name: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE
• Synonyms: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE;AKOS 91359;4-(Dimethyl-tert-butylsilyloxymethyl)pyridine;4-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]pyridine;4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-Pyridine;TBS-4-HydroxyMethylpyridine;Pyridine, 4-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-;4-(tert-butyldimethylsiloxy)methyl pyridine
• CAS NO: 117423-41-3
• Molecular Formula: C₁₂H₂₁NOSi
• Molecular Weight: 223.39
• Product Categories: Pyridine;Aromatics;Miscellaneous Reagents
• Mol File: 117423-41-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 271.495 °C at 760 mmHg
• Flash Point: 117.997 °C
• Appearance: /
• Density: 0.93 g/cm³
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: 2-8°C
• Solubility: Acetone, Chloroform, Methanol
• PKA: 5.03±0.10(Predicted)
• CAS DataBase Reference: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE(117423-41-3)
• EPA Substance Registry System: 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE(117423-41-3)

Safety Data

• Hazardous Substances Data: 117423-41-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

Protected pyridine alcohol derivative, a common synthetic reagent

InChI:InChI=1/C12H21NOSi/c1-12(2,3)15(4,5)14-10-11-6-8-13-9-7-11/h6-9H,10H2,1-5H3

Upstream product

• 586-95-8 pyridine-4-methanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 234766-95-1 2-(tert-butyldimethylsilanyloxy)-1-phenyl-2-pyridin-4-ylethanone 
• 152121-44-3 4-(4-Fluorophenyl)-2-(4-methylthiophenyl)-5-(pyridin-4-yl)-1H-imidazole 
• 152121-30-7 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(pyridin-4-yl)-1H-imidazole 
• 152121-54-5 2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole 
• 152121-19-2 2-(4-Cyanophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole 
• 166895-21-2 4-methylsulfanyl-benzoic acid 2-(4-fluoro-phenyl)-2-oxo-1-pyridin-4-yl-ethyl ester 

Relevant articles and documents

A convenient synthesis of cis-4-(sulfomethyl)-piperidine-2-carboxylic acid: NMR assignment

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MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS OF USE THEREOF

Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.