117546-56-2Relevant articles and documents
Optimization of a kilogram-scale synthesis of a potent cycloartenol triterpenoid-derived γ-secretase modulator
Fuller, Nathan O.,Hubbs, Jed L.,Austin, Wesley F.,Shen, Ruichao,Ives, Jeffrey,Osswald, Gerd,Bronk, Brian S.
, p. 683 - 692 (2014)
This work describes the demonstration of a kilogram-scale synthesis of a γ-secretase modulator from a plant-sterol-derived starting material. Key to developing a synthetic route capable of delivering a kilogram of the target compound was the development of a four-reaction telescope process and a selective O-alkylation of a triol intermediate. These improvements enabled the successful delivery of kilogram-scale batches of API for preclinical development studies.
COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS
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Paragraph 00310, (2013/03/26)
The present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer’s disease.