1185883-44-6

Basic information

• Product Name: C₃₃H₂₈F₂N₂O₅
• Synonyms: C₃₃H₂₈F₂N₂O₅
• CAS NO: 1185883-44-6
• Molecular Weight: 570.593
• Mol File: 1185883-44-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₂₈F₂N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₂₈F₂N₂O₅(1185883-44-6)
• EPA Substance Registry System: C₃₃H₂₈F₂N₂O₅(1185883-44-6)

Safety Data

• Hazardous Substances Data: 1185883-44-6(Hazardous Substances Data)

Upstream product

• 1159183-32-0 C₅₅H₄₈F₂N₂O₆ 

Downstream Products

• 1185883-40-2 C₃₃H₃₀F₂N₂O₅ 
• 1185883-38-8 C₄₁H₃₆F₂N₂O₇ 
• 1185883-42-4 C₄₁H₃₄F₂N₂O₇ 

Relevant articles and documents

INTERMEDIATES FOR THE PREPARATION OF (3R, 4S) -1- (4-FLUOROPHENYL) -3- [ (3S) -3- (4-FLUOROPHENYL) -3-HYDROXYPROPYL) ] -4- (4-HYDROXYPHENYL) -2-AZETIDINONE

A method for the preparation of (S)-alcohol oxazolidides of general formula II, in which PG represents hydrogen or a hydroxyl protecting group, such as trimethylsilyl, tert-butyldimethylsilyl, benzyloxycarbonyl, tert-butoxycarbonyl, benzyl, benzhydryl or trityl, in which a ketal oxazolidide of general formula III, where PG has the same meaning as above and R means an alkyl with 1-4 carbon atoms, linear or branched, such as methyl, ethyl, isopropyl or butyl, or R+R together represents a divalent alkyl, or substituted with 1 or 2 alkyl groups, e.g. 1,2-ethylene, 1,2-propylene, 1,2-butylene, 1,3-propylene or 2,2-dimethyl-l,3- propylene, is deprotected by the action of acidic reagents in a mixture of water and a water- miscible solvent in the temperature range of 0 to 100 °C (stage A), and the obtained ketone oxazolidide of general IV, in which PG has the same meaning as above, is reduced with asymmetrical reagents in an inert organic solvent in the temperature range of -30 to +40 °C (stage B).