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1188-38-1

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1188-38-1 Usage

Uses

Different sources of media describe the Uses of 1188-38-1 differently. You can refer to the following data:
1. carbamylphosphate synthetase activator
2. N-Carbamyl-L-glutamic Acid has been shown to have protective effects against ammonia intoxication and is used in the treatment of acute hyperammonemia.

Definition

ChEBI: A urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia.

Check Digit Verification of cas no

The CAS Registry Mumber 1188-38-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,8 and 8 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1188-38:
(6*1)+(5*1)+(4*8)+(3*8)+(2*3)+(1*8)=81
81 % 10 = 1
So 1188-38-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1

1188-38-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name carglumic acid

1.2 Other means of identification

Product number -
Other names (S)-2-Ureidopentanedioic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1188-38-1 SDS

1188-38-1Relevant articles and documents

Supramolecular assembly in the chiral N-carbamoyl compound 2-ureido-pentanedioic acid

Delgado, Gerzon E.,Mora, Asiloe J.,Gonzalez, Teresa,Uzcategui, Jorge,Lobaton, Robert,Marroquin, Gustavo

, p. 225 - 232 (2016)

The compound 2-ureido-pentanedioic acid was synthesized and characterized by FT-IR and NMR spectra. Its molecular structure was solved by single crystal X-ray diffraction. In the title compound, C6H10N2O5, the chiral structure is stabilized by intermolecular O-H···O and N-H···O hydrogen bonds in a supramolecular assembly formed by infinite chains parallel to the bc plane with graph set C(4) connected by amide-acid dimers R22(8) into a three-dimensional network.

PROCESS FOR THE PURIFICATION OF CARGLUMIC ACID AND INTERMEDIATE OF THIS PROCESS

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Page/Page column 5-6, (2021/09/08)

Method of purification of carglumic acid, substance formula I, contains the following steps: a) Dissolution of carglumic acid in dimethyl sulfoxide; b) Addition of a precipitation solvent; c) Isolation of the precipitated solvate of carglumic acid with dimethyl sulfoxide; d) Release of carglumic acid from the solvate by the help of water, possibly a mixture of water and an organic solvent, possibly a mixture of water and an organic or mineral acid, possibly a mixture of water, an organic acid and a mineral acid, possibly by an activity of an organic acid, possibly by an activity of mixture of water, a mineral acid and an organic solvent.

One-pot synthesis method of N-carbamylglutamate

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Paragraph 0013; 0014; 0015; 0016; 0017, (2018/09/21)

The invention discloses a one-pot synthesis method of N-carbamylglutamate, and belongs to the technical field of synthesis. The one-pot synthesis method of N-carbamylglutamate includes the steps thatwater serves as solvent, glutamic acid and cyanate serve as raw materials, alkali is added to adjust the pH value to 11-13, after a reaction is conducted for 2-4 hours at 50-90 DEG C, a mixture is cooled to room temperature and then stands for 10-15 hours, acid is added to adjust the pH value to make the mixture neutral, hydantoic acid serving as a catalyst is added, the mixture stands for 1-4 hours at 10-20 DEG C, and after filtration, recrystallization and drying are conducted, a product is obtained; the mole ratio of glutamic acid to cyanate is 1:(1.0-1.6), and the mole ratio of hydantoic acid to glutamic acid is (0.5-0.8):1. According to the one-pot synthesis method of N-carbamylglutamate, glutamic acid and cyanate serve as the raw materials, and through one-pot synthesis, N-carbamylglutamate is synthesized through the recrystallization after nucleophilic addition, the melting point obtained through tests is 152-155 DEG C, the yield is 55%, and the content is greater than 92%. Theone-pot synthesis method of N-carbamylglutamate has the advantages that the raw materials are cheap and easy to get, operation is simple, reaction conditions are mild, and the one-pot synthesis methodof N-carbamylglutamate is suitable for industrial production.

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