1188-38-1Relevant articles and documents
Supramolecular assembly in the chiral N-carbamoyl compound 2-ureido-pentanedioic acid
Delgado, Gerzon E.,Mora, Asiloe J.,Gonzalez, Teresa,Uzcategui, Jorge,Lobaton, Robert,Marroquin, Gustavo
, p. 225 - 232 (2016)
The compound 2-ureido-pentanedioic acid was synthesized and characterized by FT-IR and NMR spectra. Its molecular structure was solved by single crystal X-ray diffraction. In the title compound, C6H10N2O5, the chiral structure is stabilized by intermolecular O-H···O and N-H···O hydrogen bonds in a supramolecular assembly formed by infinite chains parallel to the bc plane with graph set C(4) connected by amide-acid dimers R22(8) into a three-dimensional network.
PROCESS FOR THE PURIFICATION OF CARGLUMIC ACID AND INTERMEDIATE OF THIS PROCESS
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Page/Page column 5-6, (2021/09/08)
Method of purification of carglumic acid, substance formula I, contains the following steps: a) Dissolution of carglumic acid in dimethyl sulfoxide; b) Addition of a precipitation solvent; c) Isolation of the precipitated solvate of carglumic acid with dimethyl sulfoxide; d) Release of carglumic acid from the solvate by the help of water, possibly a mixture of water and an organic solvent, possibly a mixture of water and an organic or mineral acid, possibly a mixture of water, an organic acid and a mineral acid, possibly by an activity of an organic acid, possibly by an activity of mixture of water, a mineral acid and an organic solvent.
One-pot synthesis method of N-carbamylglutamate
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Paragraph 0013; 0014; 0015; 0016; 0017, (2018/09/21)
The invention discloses a one-pot synthesis method of N-carbamylglutamate, and belongs to the technical field of synthesis. The one-pot synthesis method of N-carbamylglutamate includes the steps thatwater serves as solvent, glutamic acid and cyanate serve as raw materials, alkali is added to adjust the pH value to 11-13, after a reaction is conducted for 2-4 hours at 50-90 DEG C, a mixture is cooled to room temperature and then stands for 10-15 hours, acid is added to adjust the pH value to make the mixture neutral, hydantoic acid serving as a catalyst is added, the mixture stands for 1-4 hours at 10-20 DEG C, and after filtration, recrystallization and drying are conducted, a product is obtained; the mole ratio of glutamic acid to cyanate is 1:(1.0-1.6), and the mole ratio of hydantoic acid to glutamic acid is (0.5-0.8):1. According to the one-pot synthesis method of N-carbamylglutamate, glutamic acid and cyanate serve as the raw materials, and through one-pot synthesis, N-carbamylglutamate is synthesized through the recrystallization after nucleophilic addition, the melting point obtained through tests is 152-155 DEG C, the yield is 55%, and the content is greater than 92%. Theone-pot synthesis method of N-carbamylglutamate has the advantages that the raw materials are cheap and easy to get, operation is simple, reaction conditions are mild, and the one-pot synthesis methodof N-carbamylglutamate is suitable for industrial production.