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118854-48-1

118854-48-1

Identification

Synonyms:NSC 640233;

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Safety information and MSDS view more

  • Pictogram(s):Xi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:TRC
  • Product Description:Isopropyl4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate1,1-Dioxide(PiroxicamImpurityL)
  • Packaging:10mg
  • Price:$ 180
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Meloxicam Related Compound C
  • Packaging:30mg
  • Price:$ 1260
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:ISOPROPYL-4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE-1,1-DIOXIDE 95.00%
  • Packaging:5MG
  • Price:$ 497.95
  • Delivery:In stock
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Relevant articles and documentsAll total 4 Articles be found

Ring contraction of 3-carboxamide or 3-carboxylate of 4-hydroxy-2- methyl-2H-1,2-benzothiazine-1,1-dioxide and analogous 1 (2H)-isoquinolinone- 3-carboxylate

Khalaj, Ali,Adibpour, Neda

, p. 131 - 135 (2007/10/03)

A novel ring transformation of 3-carboxylate or 3-carboxamide of 4- hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide and analogous 1(2H)- isoquinolinone-3-carboxylate to the 5-membered rings upon the reaction with carbonyl compounds in the presence of primary or secondary amines is described.

Process for obtaining 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

-

, (2008/06/13)

A process for obtaining 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, which may be used as a non-steroidal analgesic and anti-inflammatory drug. The process comprises reacting saccharin sodium with isopropyl chloroacetate in dimethylformamide, reacting the resultant isopropyl 3-oxo-1,2-benzoisothiazoline-2-acetate 1,1-dioxide with sodium isopropylate in isopropanol to produce an intermediate which, when methylated in an aqueous-alcoholic basic medium with dimethyl sulfate, gives an intermediate compound which when condensed with 2-aminopyridine in xylene, yields 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazone-3-carboxamide 1,1-dioxide.

Process route upstream and downstream products

Process route

isopropyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
76508-35-5

isopropyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
118854-48-1

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Conditions
Conditions Yield
With sodium hydroxide; dimethyl sulfate; In water; isopropyl alcohol;
2-(Isopropoxycarbonylmethyl-methyl-sulfamoyl)-benzoic acid isopropyl ester
127861-96-5

2-(Isopropoxycarbonylmethyl-methyl-sulfamoyl)-benzoic acid isopropyl ester

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
118854-48-1

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Conditions
Conditions Yield
With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 5.5h;
66%
methyl 2-(N-methyl-N-(methoxycarbonylmethyl)sulfamoyl)benzoate
113412-07-0

methyl 2-(N-methyl-N-(methoxycarbonylmethyl)sulfamoyl)benzoate

isopropyl alcohol
67-63-0,8013-70-5

isopropyl alcohol

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
118854-48-1

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Conditions
Conditions Yield
With n-butyllithium; In tetrahydrofuran; at 20 ℃; for 6h;
53%
isopropyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
76508-35-5

isopropyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

methyl iodide
74-88-4

methyl iodide

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
118854-48-1

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Conditions
Conditions Yield
With sodium hydroxide; In ethanol; water; for 8h; Ambient temperature;
86%
(1,1,3-Trioxo-1,3-dihydro-1λ<sup>6</sup>-benzo[d]isothiazol-2-yl)-acetic acid isopropyl ester
76508-37-7

(1,1,3-Trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-acetic acid isopropyl ester

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
118854-48-1

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 1) NaO(iPr) / 1) room temperature, 7-10 min.; 2) room temperature, 2 h
2: 66 percent / lithium diisopropylamide / tetrahydrofuran / 5.5 h / -78 °C
With sodium isopropylate; lithium diisopropyl amide; In tetrahydrofuran;
2-aminopyridine
504-29-0

2-aminopyridine

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
118854-48-1

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Piroxicam
36322-90-4

Piroxicam

Conditions
Conditions Yield
In 5,5-dimethyl-1,3-cyclohexadiene;
isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
118854-48-1

isopropyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

N-methylsaccharin
15448-99-4

N-methylsaccharin

Conditions
Conditions Yield
With morpholine; 3-methyl-butan-2-one; In benzene; for 4h; Heating;
43%

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  • Finetech Industry Limited
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