118863-97-1

Basic information

• Product Name: 5-OCTYL-1,3,4-THIADIAZOL-2-AMINE
• Synonyms: 5-OCTYL-1,3,4-THIADIAZOL-2-AMINE
• CAS NO: 118863-97-1
• Molecular Formula: C10H19N3S
• Molecular Weight: 213.34
• Mol File: 118863-97-1.mol

Chemical Properties

• Boiling Point: 344.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.069±0.06 g/cm3(Predicted)
• PKA: 3.76±0.10(Predicted)
• CAS DataBase Reference: 5-OCTYL-1,3,4-THIADIAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-OCTYL-1,3,4-THIADIAZOL-2-AMINE(118863-97-1)
• EPA Substance Registry System: 5-OCTYL-1,3,4-THIADIAZOL-2-AMINE(118863-97-1)

Safety Data

• Hazardous Substances Data: 118863-97-1(Hazardous Substances Data)

Upstream product

• 14942-76-8 nonanal thiosemicarbazone 
• 124-19-6 nonan-1-al 
• 111-83-1 1-bromo-octane 
• 79-19-6 thiosemicarbazide 

Relevant articles and documents

Synthesis of Emodin Amide Derivatives Containing 1,3,4-Thiadiazole and Their Inhibitory Activity on Vibrio harveyi

A series of new 1,3,4-thiadiazole Emodin amide derivatives were synthesized through the connection of 5-substituted-1,3,4-thiadiazole-2-amine and Emodin carboxylic acids which were obtained by a two-step procedure starting from Emodin. Vibrio harveyi inhibition activities of the newly prepared compounds were evaluated. Results revealed that all compounds showed different degrees of inhibition on V. harveyi. Among them, compound 7a showed the best V. harveyi inhibition effect and the minimum inhibitory concentration (MIC) was 0.0625 mg/mL.

Preparation of 2-amino-5-alkyl -1, 3, 4-thiadiazole

The invention discloses a method for preparing 2-amino-5-alkyl-1,3,4-thiadiazole. The method comprises the following steps of adding A mol of thiosemicarbazide, B mol of carboxylic acid, C mol of phosphorus oxychloride and D mol of silica gel in a dry reaction container, grinding at a room temperature until the raw materials are completely reacted, and standing to obtain a crude product, wherein A: B: C = 1: (1 to 1.2): (1 to 1.2), and A: D = 1: (5 to 10); then adding alkaline solution in the crude product until the pH value of the obtained mixed solution is 8-8.2, then carrying out suction filtration on the mixed solution, dissolving the filter cake by a solvent and then further carrying out suction filtration, removing silica gel, then carrying out reduced pressure concentration on the finally-obtained filtrate, and removing the solvent to obtain 2-amino-5-alkyl-1,3,4-thiadiazole. The method disclosed by the invention is a solid-phase reaction, silica gel is used as a carrier, the operation process is simple, the reaction time is short, the reaction conditions are moderate, the equipment requirements are low, and the yield of the target product is up to more than 91%.

Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. II. 6-Alkyl- and 6-cycloalkylalkyl derivatives

A series of 6-alkyl- or 6-(cycloalkylalkyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyr imidin-9(3H)-ones 1b-o was synthesized from the corresponding 1,3,4-thiadiazol-5-amines 3b-o and the antiallergic activities of the products were evaluated. Among the compounds 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]p yrimidin-9(3H)-one 1h, whose X-ray crystallographic stereostructure is shown, was found to be a promising new antiallergic agent, which has low toxicity and dual activity as a leukotriene D4 receptor antagonist and as an orally active mast cell stabilizer.