1189516-65-1

Basic information

• Product Name: 9-Keto Risperidone
• Synonyms: 9-Keto Risperidone;3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-7,8-dihydro-2-Methyl-4H-pyrido[1,2-a]pyriMidine-4,9(6H)-dione;9-Keto Risperidone (90%);paliperidon Impurity 3
• CAS NO: 1189516-65-1
• Molecular Formula: C₂₃H₂₅FN₄O₃
• Molecular Weight: 424.4680032
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1189516-65-1.mol

Chemical Properties

• Melting Point: 58-62°C
• Boiling Point: 594.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Very Slightly)
• PKA: 8.02±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 9-Keto Risperidone(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Keto Risperidone(1189516-65-1)
• EPA Substance Registry System: 9-Keto Risperidone(1189516-65-1)

Safety Data

• Hazardous Substances Data: 1189516-65-1(Hazardous Substances Data)

Usage

Chemical Properties

Yellow to Orange Solid

Uses

Risperidone (R525000) impurity.

Upstream product

• 106266-06-2 Risperidone 
• 130049-82-0 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 
• 84163-77-9 6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole 

Downstream Products

• 144598-75-4 paliperidone 
• 130049-85-3 (+)-Paliperidone 

Relevant articles and documents

Selective chemical oxidation of risperidone: A straightforward and cost-effective synthesis of paliperidone

A very short and cost-effective synthesis of the commercial drug paliperidone has been achieved starting from its parent compound risperidone, through a thoroughly optimized oxidation with air under basic conditions. A very short and cost-effective synthesis of the commercial drug paliperidone (1) has been achieved starting from its parent compound risperidone, through a thoroughly optimized oxidation with air under basic conditions. Copyright

One-step process for preparing paliperidone and its oxalate salt

The present invention relates to a one-step process for the preparation of the antipsychotic agent Paliperidone by oxidation of Risperidone, and to Paliperidone oxalate or a hydrate, solvate or polymorph thereof.

NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF PALIPERIDONE

The present invention relates to a novel process for the preparation of paliperidone and its intermediates and also relates to an improved process for the preparation of paliperidone compound of formula (I).