119-27-7Relevant articles and documents
Forbes,Gregory
, p. 205 (1968)
Alkoxyphosphonium Salts. 3. Kinetics and Thermodynamics in Alkylation by Alkoxyphosphonium Salts
Lewis, Edward S.,Colle, Karla S.
, p. 4369 - 4372 (1981)
Several methoxyphosphonium trifluoromethanesulfonates (triflates) are characterized by the rates of methyl transfer to the 2,4-dinitrophenoxide ion.In acetone at 25 deg C, the measured second-order rate constants range from about 0.2 to about 40 M-1s-1, putting substances of this class among the most powerful methylating agents.The methylating power is confirmed by the measurement of the equilibrium extent of methylation of the counterion, the triflate ion.The Arbuzov rearrangement of trimethyl phosphite is slow with the catalyst methyl iodide but is fast enough with the cata lyst methyltrimethoxyphosphonium triflate to allow calorimetric measurement for the conversion of trimethyl phosphite to dimethyl methylphosphonate; ΔH = -24 +/- 2 kcal/mol.An earlier error in the measurement of the rate of this reaction is corrected, so that the mechanism of the methyl iodide catalyzed Arbuzov reaction of trimethyl phosphite is no longer in question; the first step is rate-determining.
-
Beilstein,Kellner
, p. 168 (1863)
-
Hostetler,W.,Reinheimer,J.D.
, p. 3510 - 3513 (1968)
Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium
Fauziev, Ruslan V.,Kharchenko, Alexandr K.,Kuchurov, Ilya V.,Zharkov, Mikhail N.,Zlotin, Sergei G.
, p. 25841 - 25847 (2021/08/09)
Regardless of the sustainable development path, today, there are highly demanded chemical productions still operating that bear environmental and technological risks inherited from the previous century. The fabrication of nitro compounds, and nitroarenes in particular, is traditionally associated with acidic wastes formed in nitration reactions exploiting mixed acids. However, nitroarenes are indispensable for industrial and military applications. We faced the challenge and developed a greener, safer, and yet effective method for the production of nitroaromatics. The proposed approach comprises the application of an eco-friendly nitrating agent, namely dinitrogen pentoxide (DNP), in the medium of liquefied 1,1,1,2-tetrafluoroethane (TFE) - one of the most non-hazardous Freons. Importantly, the used TFE is not emitted into the atmosphere but is effortlessly recondensed and returned into the process. DNP is obtainedviathe oxidation of dinitrogen tetroxide with ozone. The elaborated method is characterized by high yields of the targeted nitro arenes, mild reaction conditions, and minimal amount of easy-to-utilize wastes.
2 - Amino - 4 - acetamido anisole novel synthesis process (by machine translation)
-
Paragraph 0057-0058, (2018/03/01)
The present invention provides a novel 2 - amino - 4 - acetamido anisole synthesis process, the usage of palladium bi-metal catalysts and the palladium/carbon catalyst to replace Rany - Ni catalyst, to the anisole on the nitro-selective catalytic hydrogenation, which not only reduces use Rany - Ni catalyst of post-industrial risks, while at the same time, the resulting 2 - amino - 4 - acetyl anisole purity higher, greater yield. (by machine translation)
Synthesis process of 4-acetamino-2-aminoanisol
-
Paragraph 0035; 0040-0042, (2018/09/11)
The invention belongs to the field of fine chemical engineering, and discloses a synthesis process of 4-acetamino-2-aminoanisol. The synthesis method comprises the following steps: step one, adding 0.25 mol of 2,4-dinitrochlorobenzene and 100 ml of methyl alcohol, carrying out heating to 35-45 DEG C, adding a sodium hydroxide solution with a mass fraction of 20% with a decreasing speed, carrying out heating to 55-65 DEG C, carrying out filtering, diluting the filter cake with water, and carrying out drying under reduced pressure to obtain 2,4-nitroanisole; step two, preparing 200 ml of a sodium disulfide solution with a concentration of 20%, adding 0.25 mol of the 2,4-dinitroanisole, carrying out heating to a reflux temperature, then carrying out cooling to 80 DEG C, carrying out standing,washing a filter cake by using cold water, and carrying out drying under reduced pressure to obtain 2,4-diaminophenyl ether; and step three, adding 0.25 mol of 2,4-diaminoanisole, 50 ml of acetic acid and 0.1 mol of a catalyst, carrying out ice bath, adding 0.25 mol of acetic anhydride, adding 125 ml of ice water, carrying out filtering, washing a filter cake with a solution of sodium dithionite,and carrying out drying under reduced pressure to obtain the 4-acetamino-2-aminoanisol. The invention aims at providing the synthesis process of 4-acetamino-2-aminoanisol, and the synthesis method has the advantages of high recovery rate, simple process and low cost.
