119-67-5Relevant articles and documents
Synthetic application of lithiation reactions. IX. A simplified synthesis of isocoumarin
Narasimhan,Mali
, p. 797 - 797 (1975)
-
-
Matsuura et al.
, p. 6149,6154 (1968)
-
-
Cava et al.
, p. 2947 (1964)
-
-
Sidgwick,Clayton
, p. 2263 Anm. (1922)
-
-
Cava,Napier
, p. 3606 (1957)
-
Selectivity in catalytic diol electrooxidation using a polypyridine ru(iv) complex
Navarro, Marcelo,De Giovani, Wagner F.,Romero, Jose R.
, p. 851 - 857 (1991)
1,2-, 1,3-, and 1,4-Butanediols and phthatic alcohol were oxidized electrocatalytically using the polypyridine [(bpy)(trpy)RuO]2+ complex (1) as oxidant under different conditions: concentration of 1, pH, and temperature. By controlling the number of coulombs passed through the electrolytic cell, it was possible to obtain selective reactions. 1-Hydroxy-2-butanone,1-hydroxy-3-butanone, γ-butyrolactone, phthalide, phtalic aldehyde, and phthalic acid were the products obtained by controlled potential electrolysis from these substrates, with yields ranging from 41 to 89%.
Facile construction of pyrrolo[1,2-: B] isoquinolin-10(5 H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors
Wu, Shanchao,Liu, Na,Dong, Guoqiang,Ma, Lin,Wang, Shengzheng,Shi, Wencai,Fang, Kun,Chen, Shuqiang,Li, Jian,Zhang, Wannian,Sheng, Chunquan,Wang, Wei
, p. 9593 - 9596 (2016)
An efficient redox-amination-aromatization-Friedel-Crafts acylation cascade process from trans-4-hydroxyproline and 2-formylbenzoic acids has been developed for the synthesis of pyrrolo[1,2-b]isoquinolin-10(5H)-ones. Compound 3h was identified as a new potent dual topoisomerase I/II inhibitor.
Synthesis method of O-formyl benzoic acid
-
Paragraph 0009 0011-0012, (2019/12/25)
The invention discloses a synthesis method of o-formyl benzoic acid. The synthesis method includes the following steps that (1) 20 mL of o-dimethyl benzene is taken and placed in a reactor, the reactor is heated to 130 to 135 DEG C, and DMF, a catalyst and a cocatalyst are added in turn; (2) reaction liquid is cooled to the room temperature, and an obtained clear colorless crystal is o-methyl benzonitrile; and (3) the o-methyl benzonitrile is placed in the reactor, and heated to 110 to 115 DEG C, the DMF, the catalyst and the cocatalyst are added, oxygen intake is controlled to be 900 mL/min,hydrogen intake is controlled to be 100 mL/min, reaction is conducted for 2 to 3 h, and the o-formyl benzoic acid can be obtained through hydrolysis of obtained white crystalline powder under the acidic condition. The o-methyl benzonitrile is synthesized by a one-step method of liquid phase ammoxidation of o-xylene under normal pressure, then the o-formyl benzoic acid is synthesized by further oxidation of the o-methyl benzonitrile, the yield is high, the purity of product is high, and the requirements on equipment are low.
Synthesis of chiral isoindolinones via asymmetric propargylation/lactamization cascade
Meng, Jiao-Long,Jiao, Tang-Qian,Chen, Ya-Heng,Fu, Rui,Zhang, Shu-Sheng,Zhao, Qian,Feng, Chen-Guo,Lin, Guo-Qiang
supporting information, p. 1564 - 1567 (2018/03/23)
A Zn-mediated propargylation/lactamization cascade reaction with chiral 2-formylbenzoate derived N-tert-butanesulfinyl imines was realized, which provided a practical and efficient method for the synthesis of chiral isoindolinones. High diastereoselectivities (up to 97:3 dr) and good reaction yields were observed for most examined cases.
