119017-23-1

Basic information

• Product Name: 2-methyl-3-phenyl-4-phenylsulphonyl-5-styryl-2,3-dihydroisoxazole
• Synonyms: 2-methyl-3-phenyl-4-phenylsulphonyl-5-styryl-2,3-dihydroisoxazole
• CAS NO: 119017-23-1
• Molecular Weight: 403.502
• Mol File: 119017-23-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-3-phenyl-4-phenylsulphonyl-5-styryl-2,3-dihydroisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-phenyl-4-phenylsulphonyl-5-styryl-2,3-dihydroisoxazole(119017-23-1)
• EPA Substance Registry System: 2-methyl-3-phenyl-4-phenylsulphonyl-5-styryl-2,3-dihydroisoxazole(119017-23-1)

Safety Data

• Hazardous Substances Data: 119017-23-1(Hazardous Substances Data)

Upstream product

• 113549-31-8 5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole 
• 100-52-7 benzaldehyde 
• 107402-99-3 2,5-dimethyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole 
• 113549-17-0 Methanesulfonic acid 2-(4-benzenesulfonyl-2-methyl-3-phenyl-2,3-dihydro-isoxazol-5-yl)-1-phenyl-ethyl ester 

Downstream Products

• 93434-80-1 1-phenyl-4-phenylsulphonylbutan-3-one 

Relevant articles and documents

ALKYATION STUDIES OF 5-EXO-METHYLENE SUBSTITUTED ISOXAZOLIDINES

1,3-Dipolar cycloaddition of nitrones to phenylsulphonylallene gives in high yield and with complete regiospecificity 5-methyleneisoxazolidines.These on treatment with base and subsequent reaction with electrophiles afford both α- and γ-substituted products.With methyl iodide as the electrophile, only the α-methylated product was isolated.In contrast, reaction of the 5-exo-methylene-4-phenylsulphonylisoxazolidine with allyl bromide afforded the γ-allyated product.Formation of this was shown to be via direct γ-attack, rather than by α-attack, followed by a 3,3-sigmatropic rearrangement.Further studies show that the product ratio is controlled by a sensitive interplay between thermodynamic and steric factors and is very dependent on the nature of the electrophile used.