1190391-88-8Relevant articles and documents
Discovery of benzamides as potent human β3 adrenergic receptor agonists
Zhu, Cheng,Kar, Nam F.,Li, Bing,Costa, Melissa,Dingley, Karen H.,Di Salvo, Jerry,Ha, Sookhee N.,Hurley, Amanda L.,Li, Xiaofang,Miller, Randy R.,Salituro, Gino M.,Struthers, Mary,Weber, Ann E.,Hale, Jeffrey J.,Edmondson, Scott D.
, p. 55 - 59 (2015/12/18)
The paper will describe the synthesis and SAR studies that led to the discovery of benzamide (reverse amide) as potent and selective human β3-adrenergic receptor agonist. Based on conformationally restricted pyrrolidine scaffold we discovered e
COMBINATION THERAPY USING A BETA 3 ADRENERGIC RECEPTOR AGONIST AND AN ANTIMUSCARINIC AGENT
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, (2011/04/26)
Described herein is an improved method of treating overactive bladder, wherein the method comprises administering to a patient in need thereof a beta 3 adrenergic receptor agonist, an antimuscarinic agent, and an optional selective M2 antagonist. Such combination therapy provides improved efficacy and/or reduced side effects.