1195313-81-5

Basic information

• Product Name: trans-3-oxo-N-(1-phenyl-1H-pyrazol-4-yl)-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide
• CAS NO: 1195313-81-5
• Molecular Weight: 388.426
• Mol File: 1195313-81-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: trans-3-oxo-N-(1-phenyl-1H-pyrazol-4-yl)-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: trans-3-oxo-N-(1-phenyl-1H-pyrazol-4-yl)-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide(1195313-81-5)
• EPA Substance Registry System: trans-3-oxo-N-(1-phenyl-1H-pyrazol-4-yl)-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide(1195313-81-5)

Safety Data

• Hazardous Substances Data: 1195313-81-5(Hazardous Substances Data)

Upstream product

• 328233-23-4 trans-1'-oxospiro[1,3'-cyclohexane(1'H)-furo[3,4-c]pyridine]-4-carboxylic acid 
• 1128-53-6 1-phenyl-1H-pyrazol-4-amine 

Relevant articles and documents

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist

A series of trans-3-oxospiro[(aza)isobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide derivatives were synthesized to identify potent NPY Y5 receptor antagonists. Of the compounds, 21j showed high Y5 binding affinity, metabolic stability and brain and cerebrospinal fluid (CSF) penetration, and low susceptibility to P-glycoprotein transporters. Oral administration of 21j significantly inhibited the Y5 agonist-induced food intake in rats with a minimum effective dose of 1 mg/kg. This compound was selected for proof-of-concept studies in human clinical trials.