1197162-30-3

Basic information

• Product Name: N-[2-(dimethylamino)ethyl]-4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide
• CAS NO: 1197162-30-3
• Molecular Weight: 548.645
• Mol File: 1197162-30-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[2-(dimethylamino)ethyl]-4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(dimethylamino)ethyl]-4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide(1197162-30-3)
• EPA Substance Registry System: N-[2-(dimethylamino)ethyl]-4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide(1197162-30-3)

Safety Data

• Hazardous Substances Data: 1197162-30-3(Hazardous Substances Data)

Upstream product

• 6601-22-5 2,6-Dichloro-4-morpholino-1,3,5-triazine 
• 1197161-06-0 4-(chloro-6-isopropoxy-1,2,3-triazin-2yl)morpholine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1197161-07-1 4-(4-isopropoxy-6-morpholino-1,3,5-triazin-2-yl)aniline 
• 188758-93-2 N-<2-(dimethylamino)ethyl>-4-aminobenzamide 

Relevant articles and documents

Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors

We recently described several highly potent, triazine (1) and triazolopyrimidine (2) scaffold-based, dual PI3K/mTOR-inhibitors (e.g., 1, PKI-587) that were efficacious in both in vitro and in vivo models. In order to further optimize these compounds we devised a novel series, the 2-oxatriazines, which also exhibited excellent potency and good metabolic stability. Some 2-oxatriazines showed promising in vivo biomarker suppression and induced apoptosis in the MDA-MB-361 breast cancer xenograft model.