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119880-63-6

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119880-63-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 119880-63-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,8,8 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 119880-63:
(8*1)+(7*1)+(6*9)+(5*8)+(4*8)+(3*0)+(2*6)+(1*3)=156
156 % 10 = 6
So 119880-63-6 is a valid CAS Registry Number.

119880-63-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-1-nitro-2-phenylbutane

1.2 Other means of identification

Product number -
Other names (R)-1-(1-nitrobutan-2-yl)benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:119880-63-6 SDS

119880-63-6Relevant articles and documents

Highly enantioselective copper-catalyzed conjugate addition of diethylzinc to nitroalkenes

Choi, Hojae,Hua, Zihao,Ojima, Iwao

, p. 2689 - 2691 (2004)

Copper-catalyzed asymmetric conjugate addition of diethylzinc to nitroalkenes using new chiral monodentate phosphoramidite ligands proceeds with high enantioselectivity up to 99% ee.

Enantioselective conjugate addition nitro-mannich reactions: Solvent controlled synthesis of acyclic anti - And syn-β-nitroamines with three contiguous stereocenters

Anderson, James C.,Stepney, Gregory J.,Mills, Matthew R.,Horsfall, Lisa R.,Blake, Alexander J.,Lewis, William

, p. 1961 - 1971 (2011)

We report an enantioselective conjugate addition nitro-Mannich reaction protocol which combines dialkylzinc, aromatic nitro alkene and imine to form two C-C bonds and three contiguous stereocenters in one reaction vessel. Absolute stereochemistry was controlled from the initial 1,4-addition of dialkylzinc to aromatic nitroalkenes by known copper-chiral ligand catalysts. The choice of solvent dictated the formation of either the syn,anti or syn,syn diastereoisomers, two of the four possible diastereoisomers. The syn,syn isomer is a rare example of a syn-selective nitro-Mannich reaction. The diastereoselectivity is dependent upon the presence or not of Zn(O 2CCF3)2 in the reaction mixture and empirical transition state models are proposed to account for the observed stereochemical course of the two reaction conditions. The extent of enantioselectivity and structural diversity of the process is limited by current methodology for the catalytic asymmetric addition of dialkylzincs to nitrostyrenes. The synthetically versatile products are the most complex β-nitro amines prepared using the nitro-Mannich reaction and are formed in high yield and enantioselectivity.

Furanoside phosphite-phosphoroamidite and diphosphoroamidite ligands for Cu-catalyzed asymmetric 1,4-addition reactions

Raluy, Eva,Pamies, Oscar,Dieguez, Montserrat,Rosset, Stephane,Alexakis, Alexander

, p. 1930 - 1935 (2009)

A sugar-based phosphite-phosphoroamidite and diphosphoroamidite ligand library L1-L5a-g was tested in the asymmetric Cu-catalyzed 1,4-conjugate addition reactions of β-substituted and β,β′-disubstituted enones. Our results indicated that the selectivity was strongly dependent on the ligand parameters and on the substrate structure. Moderate-to-good enantioselectivities (ees up to 84%) were obtained in the 1,4-addition of several types of β-substituted cyclic and linear substrates. Of particular note is the high enantioselectivity (ees up to 90%) obtained for the more challenging β,β′-disubstituted 3-methyl-cyclohexenone.

Asymmetric Synthesis with N-Heterocyclic Carbenes. Application to the Copper-Catalyzed Conjugate Addition

Alexakis, Alexandre,Winn, Caroline L.,Guillen, Frederic,Pytkowicz, Julien,Roland, Sylvain,Mangeney, Pierre

, p. 345 - 348 (2003)

Chiral N-heterocyclic carbenes are good ligands for the copper-catalyzed conjugate addition of dialkylzinc reagents to various Michael acceptors. With as little as 4% of chiral ligand, the enantioselectivity may reach 93% on cycloheptenone.

Boosting Conjugate Addition to Nitroolefins Using Lithium Tetraorganozincates: Synthetic Strategies and Structural Insights

Dell'Aera, Marzia,Perna, Filippo Maria,Vitale, Paola,Altomare, Angela,Palmieri, Alessandro,Maddock, Lewis C. H.,Bole, Leonie J.,Kennedy, Alan R.,Hevia, Eva,Capriati, Vito

supporting information, p. 8742 - 8748 (2020/07/04)

We report the first transition metal catalyst- and ligand-free conjugate addition of lithium tetraorganozincates (R4ZnLi2) to nitroolefins. Displaying enhanced nucleophilicity combined with unique chemoselectivity and functional group tolerance, homoleptic aliphatic and aromatic R4ZnLi2 provide access to valuable nitroalkanes in up to 98 % yield under mild conditions (0 °C) and short reaction time (30 min). This is particularly remarkable when employing β-nitroacrylates and β-nitroenones, where despite the presence of other electrophilic groups, selective 1,4 addition to the C=C is preferred. Structural and spectroscopic studies confirmed the formation of tetraorganozincate species in solution, the nature of which has been a long debated issue, and allowed to unveil the key role played by donor additives on the aggregation and structure of these reagents. Thus, while chelating N,N,N’,N’-tetramethylethylenediamine (TMEDA) and (R,R)-N,N,N’,N’-tetramethyl-1,2-diaminocyclohexane (TMCDA) favour the formation of contacted-ion pair zincates, macrocyclic Lewis donor 12-crown-4 triggers an immediate disproportionation process of Et4ZnLi2 into equimolar amounts of solvent-separated Et3ZnLi and EtLi.

CuI-Catalysed Enantioselective Alkyl 1,4-Additions to (E)-Nitroalkenes and Cyclic Enones with Phosphino-Oxazoline Ligands

Shin, Minkyeong,Gu, Minji,Lim, Sung Soo,Kim, Min-Jae,Lee, JuHyung,Jin, HyeongGyu,Jang, Yun Hee,Jung, Byunghyuck

, p. 3122 - 3130 (2018/07/06)

Catalytic enantioselective conjugate additions of simple alkyl groups to nitroalkenes or cyclic enones that result in the formation of tertiary C–C bonds are described. For these stereoselective addition reactions, new chiral phosphino-oxazoline ligands w

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