1199809-29-4

Basic information

• Product Name: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol
• Synonyms: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol
• CAS NO: 1199809-29-4
• Molecular Weight: 389.386
• Mol File: 1199809-29-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol(1199809-29-4)
• EPA Substance Registry System: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol(1199809-29-4)

Safety Data

• Hazardous Substances Data: 1199809-29-4(Hazardous Substances Data)

Usage

Description

(2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol is a nucleoside analog that consists of a purine base (2-amino-6-(benzyloxy)-9H-purin-9-yl) linked to a sugar moiety (4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol). (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol is characterized by its specific stereochemistry with the (2R,3R,4R,5R) configuration, which is crucial for its biological activity and interaction with cellular enzymes. The presence of the 4-fluoro and benzyloxy substituents further modulates its pharmacological profile.

Uses

Used in Medicinal Chemistry:
(2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol is used as a nucleoside analog in medicinal chemistry for its antiviral and anticancer properties. Its unique stereochemistry and substituents contribute to its potential as a therapeutic agent.
Used in Drug Discovery:
In the field of drug discovery, (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol serves as a valuable compound for the development of new antiviral and anticancer drugs. Its specific configuration and functional groups make it a promising candidate for further research and optimization.

Upstream product

• 1199809-24-9 (((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate) 
• 1199809-22-7 ((2R,3R,4R,5R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate 
• 874638-80-9 ((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate 
• 1199809-26-1 (2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1233335-79-9 (2S)-methyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate 
• 1233343-43-5 (2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate 
• 1418141-37-3 C₂₅H₃₆FN₅O₄Si 
• 1418141-18-0 C₂₆H₂₆FN₅O₅ 
• 1418141-36-2 C₃₂H₄₀FN₅O₅Si 
• 1418141-35-1 C₃₈H₄₀FN₅O₆Si 
• 1418141-34-0 C₃₈H₄₂FN₅O₆Si 
• 1418141-33-9 C₄₄H₅₆FN₅O₆Si₂ 
• 1393526-56-1 3′,5′-bis-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-2-amino-6-benzyloxypurine ribonucleoside 

Relevant articles and documents

The synthesis of hydroxyaminopurine nucleosied (by machine translation)

A compound or salt thereof having the following structure useful for the treatment of hepatitis C virus (HCV): wherein R 7 is C 1-6 alkyl or C 3-6 cycloalkyl and R 8 is -O(C 1-6 alkyl) or -O(C 3-6 cycloalkyl).

NUCLEOSIDE ANALOGS

A purified compound having activity against hepatitis C virus is disclosed.