1201908-24-8Relevant articles and documents
Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry
Kasuga, Jun-Ichi,Ishikawa, Minoru,Yonehara, Mitsuhiro,Makishima, Makoto,Hashimoto, Yuichi,Miyachi, Hiroyuki
experimental part, p. 7164 - 7173 (2010/11/16)
To elucidate the molecular basis of peroxisome proliferator-activated receptor (PPAR) δ partial agonism, X-ray crystal structures of complexes of the PPARδ ligand-binding site with partial agonists are required. Unfortunately, reported PPARδ partial agoni