120221-75-2Relevant articles and documents
Synthesis of Azulenopyridinones through Palladium-Catalyzed Oxidative [4+2] Cyclization Reactions of N-Methoxyazulene-1- and 2-carboxamides with Alkynes
Han, Gi Uk,Son, Jeong-Yu,Park, Dahee,Eom, Hyeonsik,Lee, Kyungsup,Noh, Hee Chan,Lee, Kooyeon,Lee, Phil Ho
, p. 4749 - 4754 (2020)
Palladium-catalyzed oxidative [4+2] cyclization reactions were developed from the C?H activation reaction of N-methoxyazulene-1- and 2-carboxamides with symmetrical and unsymmetrical alkynes under a molecular oxygen atmosphere, producing azulenopyridinone derivatives with novel azulene skeletons in good to excellent yields with a wide substrate scope and excellent functional group tolerance. (Figure presented.).
Regioselective and Chemodivergent Synthesis of Azulenolactones and Azulenolactams from Rhodium(III)-Catalyzed Reactions of Azulenecarboxamides with Sulfoxonium Ylides
Lee, Seung Cheol,Son, Jeong-Yu,Kim, Jin Young,Eom, Hyeonsik,Jang, Seong Bin,Lee, Phil Ho
, p. 512 - 524 (2020/11/30)
A regioselective and chemodivergent synthetic approach for azulenolactones and azulenolactams as a new scaffold was demonstrated through Rh(III)-catalyzed reaction of N-methoxyazulene-1-carboxamides with sulfoxonium ylides. Sulfoxonium ylides that act as a precursor of secondary carbene was described, leading to the selective formation of azulenolactones and azulenolactams bearing two substituents on a newly introduced double bond. This method demonstrated functionalization of less reactive 2-position of azulene to overcome the natural reactivity. (Figure presented.).
