1202701-54-9

Basic information

• Product Name: (S)-(N-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-2-oxo-5-oxazolidinyl)methylacetamide
• Synonyms: (S)-(N-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-2-oxo-5-oxazolidinyl)methylacetamide
• CAS NO: 1202701-54-9
• Molecular Weight: 369.355
• Mol File: 1202701-54-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-(N-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-2-oxo-5-oxazolidinyl)methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(N-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-2-oxo-5-oxazolidinyl)methylacetamide(1202701-54-9)
• EPA Substance Registry System: (S)-(N-3-(3-fluoro-4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-2-oxo-5-oxazolidinyl)methylacetamide(1202701-54-9)

Safety Data

• Hazardous Substances Data: 1202701-54-9(Hazardous Substances Data)

Upstream product

• 84249-14-9 2-amino-4-bromopyridine 
• 1053655-66-5 7-bromo-[1,2,4]triazolo[1,5-a]pyridine 

Relevant articles and documents

Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure

Novel oxazolidinone analogues bearing a condensed heteroaromatic ring as the C-ring substructure were synthesized as candidate antibacterial agents. Analogues 16 and 21 bearing imidazo[1,2-a]pyridine and 18 and 23 bearing [1,2,4]triazolo[1,5-a]pyridine as the C-ring had excellent in vitro antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). They also showed promising therapeutic effects in a mouse model of lethal infection. Preliminary safety data (inhibitory effects on cytochrome P450 isoforms and monoamine oxidases) were satisfactory. Further evaluation of 18 and 23 is ongoing.