1202858-68-1

Basic information

• Product Name: 1-BroMo-5-isopropoxy-2-Methyl-4-nitrobenzene
• Synonyms: 1-BroMo-5-isopropoxy-2-Methyl-4-nitrobenzene;2-BroMo-4-isopropoxy-5-nitrotoluene;EOS-61039;CR-7
• CAS NO: 1202858-68-1
• Molecular Formula: C10H12BrNO3
• Molecular Weight: 274.11118
• EINECS: -0
• Mol File: 1202858-68-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 342.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.434±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-BroMo-5-isopropoxy-2-Methyl-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BroMo-5-isopropoxy-2-Methyl-4-nitrobenzene(1202858-68-1)
• EPA Substance Registry System: 1-BroMo-5-isopropoxy-2-Methyl-4-nitrobenzene(1202858-68-1)

Safety Data

• Hazardous Substances Data: 1202858-68-1(Hazardous Substances Data)

Usage

General Description

1-Bromo-5-isopropoxy-2-methyl-4-nitrobenzene is a chemical compound with the molecular formula C10H12BrNO3. It is an organic compound that contains a bromine atom, an isopropoxy group, a methyl group, and a nitro group attached to a benzene ring. 1-BroMo-5-isopropoxy-2-Methyl-4-nitrobenzene is commonly used in organic synthesis and has applications in the pharmaceutical industry and in the production of fine chemicals. It is important to handle this chemical with caution, as it can be toxic and harmful if ingested or inhaled. Additionally, it should be stored and disposed of properly to avoid environmental contamination.

Upstream product

• 1422-53-3 2-bromo-4-fluorotoluene 
• 1254062-68-4 2-bromo-4-isopropoxy-1-methylbenzene 
• 60710-39-6 3-bromo-p-cresol 
• 64695-96-1 1-bromo-5-fluoro-2-methyl-4-nitrobenzene 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 1032903-64-2 4-(4-{5-chloro-4-[2-(propane-2-sulfonyl)phenylamino]pyrimidin-2-ylamino}-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1032903-52-8 4-(2-methyl-4-nitro-5-isopropoxyphenyl)-5,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester 

Relevant articles and documents

Anaplastic lymphoma kinase (ALK) inhibitor, and preparation method and application thereof

The invention relates to a compound as shown in a formula (I) which is described in the specification, and a pharmaceutical composition and a preparation method thereof. The compound can be used as anALK inhibitor for treatment of diseases mediated by ALK. The invention further relates to application of the compound as shown in the formula (I) and the pharmaceutical composition thereof to preparation of drugs used for treating diseases mediated by ALK.

PROCESS FOR PREPARATION OF CERITINIB

The present application relates to a process for preparation of ceritinib and intermediates thereof. Specifically, the present application relates to a process for preparation of N-(4-(1-benzyl- 1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)acetamide (VC) comprising treating N-(4-(bromomethyl)-2-isopropoxy-5-methylphenyl)acetamide (IIID) with 1- benzylpiperidin-4-one (IVA). The present application also relates to a process for conversion of N-(4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)-acetamide (VC) to ceritinib or an acid-addition salt thereof.

DEUTERATED DIAMINOPYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS

The present invention related to deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds. In particular, disclosed are the deuterated diaminopyrimidine compounds shown as formula (I), and the pharmaceutical compositions comprising such compounds or crystal form, pharmaceutically acceptable salts, hydrates or solvates thereof. The compounds of the present invention can be used for treating and/or preventing protein kinase-associated diseases, such as cell proliferative disease, cancer, immune disease and the like.