1205-41-0

Basic information

• Product Name: 2-Pyridinamine, N-(1-oxido-2-pyridinyl)-
• CAS NO: 1205-41-0
• Molecular Formula: C10H9N3O
• Molecular Weight: 187.201
• Mol File: 1205-41-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Pyridinamine, N-(1-oxido-2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinamine, N-(1-oxido-2-pyridinyl)-(1205-41-0)
• EPA Substance Registry System: 2-Pyridinamine, N-(1-oxido-2-pyridinyl)-(1205-41-0)

Safety Data

• Hazardous Substances Data: 1205-41-0(Hazardous Substances Data)

Upstream product

• 14150-95-9 2-aminopyridine N-oxide 
• 372-48-5 2-fluoropyridine 
• 109-04-6 2-bromo-pyridine 
• 109-09-1 2-chloropyridine 

Downstream Products

• 1202-34-2 di(pyridin-2-yl)amine 

Relevant articles and documents

Cine substitution in reaction of unactivated 2-halopyridines with 2-aminopyridine 1-oxide. Formation of 3-(2-pyridylamino)-2(1H)-pyridone [1]

Reaction of 2-aminopyridine 1-oxide 1a with2-fluoropyridine 5a in DMF at 140°C gave 2-(2-pyridylamino)pyridine 1-oxide 6 (41%) along with bis(2-pyridyl)amine 7 (5%). However, heating in melt of 1a with 2-chloropyridine 5b or 2-bromopyridine 5c in the presence of dry potassium carbonate at 175°C provided 3-(2-pyridylamino)-2(1H)-pyridone 9 as cine substitution product. Compound 9 results from the nucleophilic attack of the N-oxide on the carbon atom bearing halogen to give corresponding cation 17, which rearranges to cine substitution product 9 via anhydro-base 18.