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120638-55-3

Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate, also known as Bromfenac, is a non-steroidal anti-inflammatory agent (NSAID) with potent analgesic and anti-inflammatory properties. It is structurally similar to ketoprofen and diclofenac and is used to manage ocular pain and treat postoperative inflammation in patients who have undergone cataract extraction. Bromfenac works by reducing prostaglandin production through the inhibition of cyclooxygenase, leading to its analgesic and anti-inflammatory effects.

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  • 120638-55-3 Structure

  • Basic information

    1. Product Name: Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate
    2. Synonyms: Bromfenac sodium;Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate;Benzeneacetic acid, 2-amino-3-(4-bromobenzoyl)-, monosodium salt, hydrate (2:3);Bromfenac ophthalmic;Bromfenac ophthalmic solution;Duract;Sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate;Unii-8ecv571Y37
    3. CAS NO:120638-55-3
    4. Molecular Formula: C15H11BrNNaO3
    5. Molecular Weight: 356.15
    6. EINECS: 1533716-785-6
    7. Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
    8. Mol File: 120638-55-3.mol

  • Chemical Properties

    1. Melting Point: 268-270°C (dec.)
    2. Boiling Point: 562.2ºC
    3. Flash Point: 293.8ºC
    4. Appearance: /
    5. Density: 1.565 g/cm3
    6. Vapor Pressure: 1.77E-13mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Refrigerator
    9. Solubility: N/A
    10. CAS DataBase Reference: Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate(CAS DataBase Reference)
    11. NIST Chemistry Reference: Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate(120638-55-3)
    12. EPA Substance Registry System: Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate(120638-55-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 120638-55-3(Hazardous Substances Data)

120638-55-3 Usage

Uses

Used in Ophthalmology:
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate is used as an ophthalmic solution for the treatment of postoperative inflammation and reduction of ocular pain in patients after cataract extraction. It is applied topically to the affected eye twice daily, starting 24 hours after surgery and continuing for the first 2 weeks of the postoperative period.
Used in Non-Steroidal Anti-Inflammatory Therapy:
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate is used as a non-steroidal anti-inflammatory agent for managing pain and inflammation. It is particularly effective in the rapid resolution of ocular pain after cataract surgery, with statistically significant differences demonstrated between the bromfenac and placebo groups in phase III clinical trials.
Used in Comparative Investigations:
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate is used as a therapeutic agent in the treatment of external or anterior ocular inflammatory diseases, allergic conjunctivitis, scleritis, and postoperative inflammation. Its clinical safety and efficacy have been extensively studied in diverse comparative investigations.
Chemical Properties:
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate is a yellow solid with the brand name Xibrom (Ista). It is the sesquihydrate of the sodium salt of bromfenac and is known for its potent analgesic and anti-inflammatory effects, making it a valuable compound in the field of ophthalmology and pain management.

Originator

American Home Products (US)

Check Digit Verification of cas no

The CAS Registry Mumber 120638-55-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,6,3 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 120638-55:
(8*1)+(7*2)+(6*0)+(5*6)+(4*3)+(3*8)+(2*5)+(1*5)=103
103 % 10 = 3
So 120638-55-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H12BrNO3.Na.H2O/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;;/h1-7H,8,17H2,(H,18,19);;1H2/q;+1;/p-1

120638-55-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name bromfenac sodium salt sesquihydrate

1.2 Other means of identification

Product number -
Other names Bromfenac monosodium salt sesquihydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120638-55-3 SDS

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