1207370-28-2 Usage
Description
2-Pyridinone-6-boronic ester is a versatile chemical compound that is a boronic ester derivative of 2-pyridinone, a heterocyclic compound frequently found in pharmaceuticals and agrochemicals. 2-pyridinone-6-boronic ester is characterized by its boronic ester functional group, which is significant in organic chemistry due to its ability to participate in various reactions, such as the Suzuki-Miyaura cross-coupling, to form carbon-carbon bonds. Its unique structure and reactivity make it a promising candidate for the synthesis of pharmaceuticals and bioactive molecules, as well as a useful building block for creating new chemical entities with potential biological activity.
Uses
Used in Organic Synthesis:
2-Pyridinone-6-boronic ester is used as a key intermediate in organic synthesis for the creation of new chemical entities. Its reactivity allows for the formation of carbon-carbon bonds, which is crucial in constructing complex molecular structures.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-pyridinone-6-boronic ester is utilized as a building block for the development of pharmaceuticals. Its unique structure contributes to the design of novel compounds with potential therapeutic applications.
Used in the Synthesis of Bioactive Molecules:
2-Pyridinone-6-boronic ester is employed as a precursor in the synthesis of bioactive molecules, which may have applications in various industries, including pharmaceuticals, agrochemicals, and materials science, due to their potential biological activity.
Used in the Development of New Compounds for Various Industries:
2-pyridinone-6-boronic ester is used as a versatile chemical in the development of new compounds across different industries. Its role in creating molecules with potential applications in medicine, agriculture, and other fields highlights its importance in chemical research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 1207370-28-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,7,3,7 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1207370-28:
(9*1)+(8*2)+(7*0)+(6*7)+(5*3)+(4*7)+(3*0)+(2*2)+(1*8)=122
122 % 10 = 2
So 1207370-28-2 is a valid CAS Registry Number.
1207370-28-2Relevant articles and documents
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents
Niculescu-Duvaz, Dan,Niculescu-Duvaz, Ion,Suijkerbuijk, Bart M.J.M.,Ménard, Delphine,Zambon, Alfonso,Davies, Lawrence,Pons, Jean-Francois,Whittaker, Steven,Marais, Richard,Springer, Caroline J.
, p. 1284 - 1304 (2013/03/14)
The RAS-RAF-MEK-ERK pathway is hyperactivated in 30% of human cancers. BRAF is a serine-threonine kinase, belonging to this pathway that is mutated with high frequency in human melanoma and other cancers thus BRAF is an important therapeutic target in melanoma. We have designed inhibitors of BRAF based on 2,4,5-trisubstituted imidazoles with naphthyl and benzothiophene-4-substituents. Two compounds were discovered to be potent BRAF inhibitors: 1-(6-{2-[4-(2-dimethylamino-ethoxy)phenyl]-5-(pyridin-4-yl)-1H-imidazol-4-yl} benzo[b]thiophen-3-yl)-2,2,2-trifluoroethanol (1i) with BRAF IC50 = 190 nM and with cellular GI50 = 2100 nM, and 6-{2-[4-(2- dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-naphthalen-1-ol (1q) with IC50 = 9 nM and GI50 = 220 nM.
